DK1855650T3 - Vandig, topisk gel med høj stabilitet baseret på metronidazol og fremgangsmåde til fremstilling heraf - Google Patents

Vandig, topisk gel med høj stabilitet baseret på metronidazol og fremgangsmåde til fremstilling heraf

Info

Publication number
DK1855650T3
DK1855650T3 DK06707447.6T DK06707447T DK1855650T3 DK 1855650 T3 DK1855650 T3 DK 1855650T3 DK 06707447 T DK06707447 T DK 06707447T DK 1855650 T3 DK1855650 T3 DK 1855650T3
Authority
DK
Denmark
Prior art keywords
metronidazole
preparation
high stability
topical gel
gel based
Prior art date
Application number
DK06707447.6T
Other languages
English (en)
Inventor
Alain Brzokewicz
Leila Zarif
Gerald Pedrassi
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Application granted granted Critical
Publication of DK1855650T3 publication Critical patent/DK1855650T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
DK06707447.6T 2005-02-25 2006-02-16 Vandig, topisk gel med høj stabilitet baseret på metronidazol og fremgangsmåde til fremstilling heraf DK1855650T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0501949A FR2882552B1 (fr) 2005-02-25 2005-02-25 Gel aqueux de haute stabilite a base de metronidazole et procedes pour leur preparation
US67163505P 2005-04-15 2005-04-15
PCT/EP2006/002074 WO2006089804A1 (en) 2005-02-25 2006-02-16 Aqueous topical gel of high stability based on metronidazole and method of preparation

Publications (1)

Publication Number Publication Date
DK1855650T3 true DK1855650T3 (da) 2013-02-25

Family

ID=35044713

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06707447.6T DK1855650T3 (da) 2005-02-25 2006-02-16 Vandig, topisk gel med høj stabilitet baseret på metronidazol og fremgangsmåde til fremstilling heraf

Country Status (19)

Country Link
US (1) US20090215849A1 (da)
EP (1) EP1855650B1 (da)
JP (1) JP2008531517A (da)
KR (1) KR20070112139A (da)
CN (1) CN101128185A (da)
AR (1) AR054228A1 (da)
AU (1) AU2006218043B2 (da)
BR (1) BRPI0608044A2 (da)
CA (1) CA2598031A1 (da)
DK (1) DK1855650T3 (da)
ES (1) ES2400502T3 (da)
FR (1) FR2882552B1 (da)
MX (1) MX2007010179A (da)
PL (1) PL1855650T3 (da)
PT (1) PT1855650E (da)
RU (1) RU2409346C2 (da)
SI (1) SI1855650T1 (da)
WO (1) WO2006089804A1 (da)
ZA (1) ZA200707558B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946276B2 (en) 2011-06-28 2015-02-03 Watson Laboratories, Inc. High dosage mucoadhesive metronidazole aqueous-based gel formulations and their use to treat bacterial vaginosis
CN113476397B (zh) * 2021-07-12 2022-11-18 海南海神同洲制药有限公司 一种甲硝唑凝胶及其制备方法
CN115350144A (zh) * 2022-07-28 2022-11-18 苏州弘森药业股份有限公司 一种甲硝唑水凝胶及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837378A (en) * 1986-01-15 1989-06-06 Curatek Pharmaceuticals, Inc. Topical metronidazole formulations and therapeutic uses thereof
KR950003919B1 (ko) * 1987-03-20 1995-04-20 갈데르마 에스. 에이. 국소용 메트로니다졸 제제의 제조방법
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
JP2533723B2 (ja) * 1992-12-28 1996-09-11 東興薬品工業株式会社 速乾性ゲルタイプ手指消毒剤
FR2700952B1 (fr) * 1993-01-29 1995-03-17 Oreal Nouvelles compositions cosmétiques ou dermopharmaceutiques sous forme de gels aqueux modifiés par addition de microsphères expansées.
FR2722098B1 (fr) * 1994-07-06 1996-08-23 Cird Galderma Nouveaux medicaments a base de metro-nidazole ou d'un melange synergetique de metronidazole et de clindamycine
IN188720B (da) * 1997-11-06 2002-11-02 Panacea Biotec Ltd
JP2002512187A (ja) * 1998-04-17 2002-04-23 バーテック ファーマシューティカルズ，インコーポレイティド 爪真菌病の処置のための局所製剤
US7074832B2 (en) * 2001-09-24 2006-07-11 Bradley Pharmaceuticals, Inc. Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
US7368122B1 (en) * 2002-03-08 2008-05-06 Dow Pharmaceutical Sciences Skin cream
US6846837B2 (en) * 2002-06-21 2005-01-25 Howard I. Maibach Topical administration of basic antifungal compositions to treat fungal infections of the nails
AR041021A1 (es) * 2002-08-22 2005-04-27 Novartis Consumer Health Sa Composicion topica
US20060093675A1 (en) * 2004-10-29 2006-05-04 Mathew Ebmeier Intravaginal treatment of vaginal infections with metronidazole compositions

Also Published As

Publication number Publication date
AU2006218043A1 (en) 2006-08-31
CA2598031A1 (en) 2006-08-31
FR2882552A1 (fr) 2006-09-01
RU2007135364A (ru) 2009-03-27
US20090215849A1 (en) 2009-08-27
ES2400502T3 (es) 2013-04-10
ZA200707558B (en) 2008-10-29
FR2882552B1 (fr) 2008-12-26
BRPI0608044A2 (pt) 2009-11-03
AU2006218043B2 (en) 2012-02-02
WO2006089804A1 (en) 2006-08-31
CN101128185A (zh) 2008-02-20
PL1855650T3 (pl) 2013-04-30
RU2409346C2 (ru) 2011-01-20
AR054228A1 (es) 2007-06-13
EP1855650A1 (en) 2007-11-21
MX2007010179A (es) 2007-09-18
PT1855650E (pt) 2013-02-28
EP1855650B1 (en) 2012-12-05
JP2008531517A (ja) 2008-08-14
SI1855650T1 (sl) 2013-05-31
KR20070112139A (ko) 2007-11-22

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