AR050411A1 - Ureas trisustituidas como inhibidores de citocina. composiciones farmaceuticas - Google Patents
Ureas trisustituidas como inhibidores de citocina. composiciones farmaceuticasInfo
- Publication number
- AR050411A1 AR050411A1 ARP050101610A ARP050101610A AR050411A1 AR 050411 A1 AR050411 A1 AR 050411A1 AR P050101610 A ARP050101610 A AR P050101610A AR P050101610 A ARP050101610 A AR P050101610A AR 050411 A1 AR050411 A1 AR 050411A1
- Authority
- AR
- Argentina
- Prior art keywords
- unsubstituted
- substituted
- iii
- formula
- carbocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Composicion farmacéutica que comprende dicho compuesto y uno o más excipientes farmacéuticamente compatibles. Reivindicacion 1: Un compuesto, inclusive todas las formas enantiomeros o diastereoméricas y las sales farmacéuticamente aceptables de éstas; dicho compuesto tiene la formula (1), en donde R tiene la formula: -(L)x-R3; R3 se selecciona de: i) arilo de C6-10 sustituido o no sustituido; heteroarilo de C1-10 sustituido o no sustituido; iii) carbocíclico de C3-10 sustituido o no sustituido; o iv) heterocíclico de C1-10 sustituido o no sustituido; el índice x es 0 o 1; R1 tiene la formula: -(L1)y-R5; R5 es una unidad seleccionada de: i) carbocíclico de C3-10 sustituido o no sustituido; ii) arilo de C6-10 sustituido o no sustituido; iii) heterocíclico de C1-10 sustituido o no sustituido; y iv) heteroarilo de C1-10 sustituido o no sustituido; el índice y es 0 o 1; R2 tiene la formula: -(L2)z-R6; R6 es una unidad seleccionada de: i) hidrogeno; ii) hidrocarbilo de C1- 10 lineal o ramificado, sustituido o no sustituido; iii) carbocíclico de C3-10 sustituido o no sustituido; iv) arilo de C6-10 sustituido o no sustituido; v) heterocíclico de C1-10 sustituido o no sustituido; y vi) heteroarilo de C1-10 sustituido o no sustituido; el índice z es 0 o 1; L, L1 y L2 son grupos enlazantes; cada uno de ellos se selecciona independientemente de: i) -C(R7)2-; ii) -NR7-; y iii) -O-; R7 es hidrogeno, alquilo de C1-4 y mezclas de éstos; o dos unidades R7 pueden unirse para formar una unidad carbonilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56474504P | 2004-04-22 | 2004-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050411A1 true AR050411A1 (es) | 2006-10-25 |
Family
ID=34967029
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101610A AR050411A1 (es) | 2004-04-22 | 2005-04-22 | Ureas trisustituidas como inhibidores de citocina. composiciones farmaceuticas |
| ARP050101611A AR048874A1 (es) | 2004-04-22 | 2005-04-22 | Ureas trisustituidas como inhibidores de citocina, composicion farmaceutica que comprende al compuesto; preparacion del mismo y su uso en la prepa-racion de un medicamento |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050101611A AR048874A1 (es) | 2004-04-22 | 2005-04-22 | Ureas trisustituidas como inhibidores de citocina, composicion farmaceutica que comprende al compuesto; preparacion del mismo y su uso en la prepa-racion de un medicamento |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7449474B2 (es) |
| EP (2) | EP1747204B1 (es) |
| JP (2) | JP2007534688A (es) |
| KR (1) | KR100883937B1 (es) |
| CN (2) | CN1946701A (es) |
| AR (2) | AR050411A1 (es) |
| AT (1) | ATE402927T1 (es) |
| AU (1) | AU2005238484A1 (es) |
| BR (1) | BRPI0510128A (es) |
| CA (2) | CA2564589A1 (es) |
| DE (1) | DE602005008581D1 (es) |
| DK (1) | DK1747204T3 (es) |
| ES (1) | ES2311223T3 (es) |
| HR (1) | HRP20080489T3 (es) |
| IL (1) | IL178459A0 (es) |
| MA (1) | MA28638B1 (es) |
| MX (2) | MXPA06012188A (es) |
| NO (1) | NO20065142L (es) |
| PE (2) | PE20060338A1 (es) |
| PL (1) | PL1747204T3 (es) |
| PT (1) | PT1747204E (es) |
| RU (1) | RU2338739C2 (es) |
| SI (1) | SI1747204T1 (es) |
| SM (1) | SMP200600037B (es) |
| TW (2) | TW200538105A (es) |
| WO (2) | WO2005105757A1 (es) |
| ZA (1) | ZA200609326B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| CN108976172B (zh) * | 2017-05-31 | 2021-12-07 | 华东师范大学 | 一类4-嘧啶二胺类小分子有机化合物及其衍生物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| HU206337B (en) * | 1988-12-29 | 1992-10-28 | Mitsui Petrochemical Ind | Process for producing pyrimidine derivatives and pharmaceutical compositions |
| JP2001521934A (ja) * | 1997-11-03 | 2001-11-13 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | 抗炎症薬としての芳香族ヘテロ環式化合物 |
| MXPA01009077A (es) * | 1999-03-12 | 2002-03-27 | Boehringer Ingelheim Pharma | Composiciones heterociclicos aromaticos como agentes anti-inflamatorios. |
| EP1395561A1 (en) * | 2001-05-25 | 2004-03-10 | Boehringer Ingelheim Pharmaceuticals Inc. | Carbamate and oxamide compounds as inhibitors of cytokine production |
| ES2284887T3 (es) * | 2001-07-11 | 2007-11-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Metodos para tratar enfermedades transmitidas por citocinas. |
-
2005
- 2005-04-20 CN CNA2005800125453A patent/CN1946701A/zh active Pending
- 2005-04-20 KR KR1020067024157A patent/KR100883937B1/ko not_active IP Right Cessation
- 2005-04-20 SI SI200530424T patent/SI1747204T1/sl unknown
- 2005-04-20 EP EP05740166A patent/EP1747204B1/en active Active
- 2005-04-20 PL PL05740166T patent/PL1747204T3/pl unknown
- 2005-04-20 WO PCT/US2005/013868 patent/WO2005105757A1/en active Application Filing
- 2005-04-20 TW TW094112578A patent/TW200538105A/zh unknown
- 2005-04-20 CA CA002564589A patent/CA2564589A1/en not_active Abandoned
- 2005-04-20 JP JP2007509682A patent/JP2007534688A/ja active Pending
- 2005-04-20 BR BRPI0510128-0A patent/BRPI0510128A/pt not_active IP Right Cessation
- 2005-04-20 JP JP2007509683A patent/JP2007534689A/ja active Pending
- 2005-04-20 TW TW094112581A patent/TW200539883A/zh unknown
- 2005-04-20 AU AU2005238484A patent/AU2005238484A1/en not_active Abandoned
- 2005-04-20 ES ES05740166T patent/ES2311223T3/es active Active
- 2005-04-20 SM SM200600037T patent/SMP200600037B/it unknown
- 2005-04-20 DE DE602005008581T patent/DE602005008581D1/de not_active Expired - Fee Related
- 2005-04-20 PT PT05740166T patent/PT1747204E/pt unknown
- 2005-04-20 CN CNA2005800124183A patent/CN1946700A/zh active Pending
- 2005-04-20 DK DK05740166T patent/DK1747204T3/da active
- 2005-04-20 MX MXPA06012188A patent/MXPA06012188A/es not_active Application Discontinuation
- 2005-04-20 EP EP05740317A patent/EP1737830A1/en not_active Withdrawn
- 2005-04-20 RU RU2006140694/04A patent/RU2338739C2/ru active
- 2005-04-20 CA CA002564587A patent/CA2564587A1/en not_active Abandoned
- 2005-04-20 AT AT05740166T patent/ATE402927T1/de not_active IP Right Cessation
- 2005-04-20 WO PCT/US2005/013869 patent/WO2005105758A1/en active Application Filing
- 2005-04-20 MX MXPA06012189A patent/MXPA06012189A/es active IP Right Grant
- 2005-04-21 US US11/111,581 patent/US7449474B2/en not_active Expired - Fee Related
- 2005-04-21 US US11/111,612 patent/US7402589B2/en not_active Expired - Fee Related
- 2005-04-22 PE PE2005000450A patent/PE20060338A1/es not_active Application Discontinuation
- 2005-04-22 AR ARP050101610A patent/AR050411A1/es not_active Application Discontinuation
- 2005-04-22 AR ARP050101611A patent/AR048874A1/es not_active Application Discontinuation
- 2005-04-22 PE PE2005000451A patent/PE20060258A1/es not_active Application Discontinuation
-
2006
- 2006-10-05 IL IL178459A patent/IL178459A0/en unknown
- 2006-11-08 NO NO20065142A patent/NO20065142L/no not_active Application Discontinuation
- 2006-11-09 ZA ZA200609326A patent/ZA200609326B/xx unknown
- 2006-11-21 MA MA29478A patent/MA28638B1/fr unknown
-
2008
- 2008-09-30 HR HR20080489T patent/HRP20080489T3/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| ECSP11011427A (es) | Piperidinas sustituidas como antagonistas de ccr3. | |
| ME00972B (me) | NOVI DERIVATI 6-TRIAZOLOPIRIDAZINSULFANIL BENZOTIAZOLA I BENZIMIDAZOLA, POSTUPAK ZA NJIHOVO DOBIJANJE l UPOTREBA KAO LJEKOVA l FARMACEUTSKIH KOMPOZICIJA l NOVA UPOTREBA KAO INHIBITORA MET-a | |
| AR054560A1 (es) | Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer | |
| AR078152A1 (es) | Compuestos heterociclicos, utiles para el tratamiento de hcv y composiciones farmaceuticas que los comprenden | |
| CO6170361A2 (es) | Composiciones y metodos para modular receptores de c-kit y pdgfr | |
| BRPI0617167B8 (pt) | sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação | |
| CR10643A (es) | DERIVADOS DE 2-ARIL-6-FENIL-IMIDAZOL[1,2-a]PIRIDINAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA | |
| CR11683A (es) | Piridinas y pirazinas como inhibidores de p13k | |
| PE20080702A1 (es) | PROLINAMIDAS SUSTITUIDAS COMO INHIBIDORES DEL FACTOR Xa | |
| PE20070804A1 (es) | Compuestos heterociclicos como inhibidores de proteasa aspartica | |
| AR050435A1 (es) | DERIVADOS DE HIDROXIAMIDA, PROCESOS DE OBTENCIoN Y COMPOSICIONES FARMACÉUTICAS. | |
| AR066972A1 (es) | Derivados azapeptidicos | |
| PE20080355A1 (es) | Compuestos peptidicos como inhibidores de proteasa de serina del virus de hepatitis c | |
| AR094790A1 (es) | Derivados sustituidos del ácido bisfenil butanóico fosfónico como inhibidores de la nep | |
| CO5690589A2 (es) | Antagonistas de la hormona concentradora de melanina | |
| PE20081834A1 (es) | Proceso para la sintesis de derivados de acido 3-amino-tetrahidrofuran-3-carboxilico y uso de los mismos como medicamentos | |
| AR045999A1 (es) | Compuesto de eter de piperidina, su uso para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para prepararlo | |
| PE20091079A1 (es) | Compuestos heterociclicos como moduladores npy y2 | |
| CO5580782A2 (es) | Antibioticos de glicopeptido-cefalosporina entrecruzados | |
| AR037502A1 (es) | Compuesto de 6,7-dihidro-5h-pirazolo[1,2a]pirazol-1-ona espirociclico y su uso para fabricar una composicion farmaceutica | |
| ECSP11011415A (es) | Piperidinas sustituidas como antagonistas de ccr3. | |
| BR0313734A (pt) | Derivados do tiofeno, o seu processo de preparação e as composições farmacêuticas que os contêm | |
| AR050411A1 (es) | Ureas trisustituidas como inhibidores de citocina. composiciones farmaceuticas | |
| EA200701476A1 (ru) | Новые гетероциклические соединения оксима, способ их получения и фармацевтические композиции, которые их содержат |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |