AR050245A1 - 3-piperidinilisocroman-5-oles como agonistas de dopamina y composicion farmaceutica que lo contiene - Google Patents
3-piperidinilisocroman-5-oles como agonistas de dopamina y composicion farmaceutica que lo contieneInfo
- Publication number
- AR050245A1 AR050245A1 ARP050101668A ARP050101668A AR050245A1 AR 050245 A1 AR050245 A1 AR 050245A1 AR P050101668 A ARP050101668 A AR P050101668A AR P050101668 A ARP050101668 A AR P050101668A AR 050245 A1 AR050245 A1 AR 050245A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- hydrogen
- phenyl
- benzyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Estos compuestos son utiles para tratar trastornos neurologicos relacionados con la dopamina, seleccionados del grupo que consiste en trastornos neurologicos, psicologicos, cardiovasculares, cognitivos o de atencion, abuso de sustancias y comportamiento adictivo, o una de sus combinaciones, que comprende administrar a un paciente que necesite dicho tratamiento, una cantidad terapéuticamente eficaz de compuestos de formula 1 Reivindicacion 1: Un compuesto de acuerdo con la formula 1 en la que R1 se selecciona del grupo que consiste en hidrogeno, fenoxicarbonilo, alcoxi(C1-6)-carbonilo, benciloxicarbonilo, naftiloxicarbonilo, fenilcarbamoilo, fenilcarbamoil-alquilo (C1-6), bifenilcarbamoilo, fenil-alquil(C1-6)-carbamoilo, N- fenil-N-alquil(C1-6)-carbamoilo, alquil(C1-6)- y dialquil(C1-6)-carbamoilo, alquenil(C2-6)- y dialquenil(C2-6)-carbamoilo, difenilcarbamoilo, heteroarilcarbamoil-alquilo(C1-6), fenilcarbonilo, bifenilcarbonilo, alquil(C1-6)-carbonilo, morfolinilcarbonilo, piperidinilcarbonilo, pirrolidinilcarbonilo, fenotiazinilcarbonilo, fenilsulfonilo, difenilsulfonilo, naftilsulfonilo, alquilsulfonilo C1-10, naftil-alquil(C1-6)- sulfonilo, perfluoralquilsulfonilo C1-6, difenil-alquil(C1-6)- sulfonilo, bencenosulfonilo, dialquil(C1-6)-aminosulfonilo, difenil-alquilo(C1-6), bencilo, fenil-alquilo(C2-6), naftil-alquilo(C1-6); cicloalquil(C3-6)-alquilo(C1-6), fenil-alquienilo(C1-6), heteroaril-alquilo(C1-6), alfa-carboxibencilo, fenilcarbonilalquilo(C1-6), hidroxialquilo(C1-6), bifenil-alquilo(C1-6), alquilo C1-6, fenoxifenil-alquilo(C1-6), fenilurea-alquilo,indanilo, en los que el bencilo y fenilo están opcionalmente sustituidos con uno o dos sustituyentes independientemente seleccionado cada uno del grupo que consiste en alquilo C1-6, perfluoroalquilo C1-6, halogeno, hidroxi, alcoxi C1-6 y nitro, y en los que heteroarilo es tiofenilo, benzotiofenilo, furanilo, benzofuranilo, tetrahidroquinolilo, tetrahidroisoquinolilo, indolilo, imidazolilo, bencimidazolilo, piridinilo, isotiazolilo, bencisotiazolilo, isoxazolilo, bencisoxazolilo, isoquinolilo o quinolilo, en los que el heteroarilo está opcionalmente sustituido con uno o dos sustituyentes independientemente seleccionados del grupo de alquilo C1-6, halogeno, hidroxi, bencilo y alcoxi C1-6, formula 2, 3 4 y 5 en los que R es hidrogeno o bencilo, Y se selecciona del grupo que consiste en hidrogeno, alquilo C1-6, perfluoralquilo C1-6, halogeno, hidroxi, alcoxi C1-6 y nitro; R2 y R3 son iguales o diferentes y se seleccionan independientemente del grupo que consiste en hidrogeno, alquilo C1-6, alquil (C1-6)-carbonilo, formilo, alquenilo C2-6, cicloalquilo (C3-6)-alquilo(C1-6), y R2, R3 considerados juntos pueden formar un anillo de 2-5átomos de carbono; R4 se selecciona del grupo que consiste en hidrogeno, alquilo C1-4 y alquil(C1-6)-carbonilo; X se selecciona del grupo que consiste en hidrogeno y alquilo C1-6; y n es un numero entreo 1, 2 o 3; un esteroisomero o una de sus sales farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56655704P | 2004-04-29 | 2004-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR050245A1 true AR050245A1 (es) | 2006-10-11 |
Family
ID=34967397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101668A AR050245A1 (es) | 2004-04-29 | 2005-04-28 | 3-piperidinilisocroman-5-oles como agonistas de dopamina y composicion farmaceutica que lo contiene |
Country Status (11)
Country | Link |
---|---|
US (1) | US7919508B2 (es) |
EP (1) | EP1749001B1 (es) |
JP (1) | JP4685861B2 (es) |
AR (1) | AR050245A1 (es) |
AT (1) | ATE459618T1 (es) |
DE (1) | DE602005019719D1 (es) |
DK (1) | DK1749001T3 (es) |
ES (1) | ES2342083T3 (es) |
PT (1) | PT1749001E (es) |
TW (1) | TW200607802A (es) |
WO (1) | WO2005111025A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3060551T (pt) * | 2013-10-22 | 2019-12-09 | Chiesi Farm Spa | Processo para a preparação de um inibidor de pde4 |
EP3137469B1 (en) * | 2014-04-28 | 2019-10-09 | Pfizer Inc | Heterocyclic compounds and their use as dopamine d1 ligands |
SI3204359T1 (sl) * | 2014-10-08 | 2020-10-30 | UCB Biopharma SRL | Tetrahidroizokinolinski derivati |
MA45857A (fr) | 2016-07-29 | 2021-05-19 | Sunovion Pharmaceuticals Inc | Composés et compositions, et utilisations associées |
JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 化合物および組成物ならびにそれらの使用 |
CA3034211A1 (en) | 2016-08-18 | 2018-02-22 | Vidac Pharma Ltd. | Piperazine derivatives, pharmaceutical compositions and methods of use thereof |
CA3070993A1 (en) * | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
CN111196781B (zh) * | 2018-11-16 | 2023-07-28 | 湖南中南制药有限责任公司 | 一种改进的制备五氟利多的方法 |
MX2021010880A (es) | 2019-03-14 | 2022-01-18 | Sunovion Pharmaceuticals Inc | Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4994486A (en) * | 1989-05-31 | 1991-02-19 | Abbott Laboratories | Dopaminergic compounds |
US4963568A (en) * | 1989-05-31 | 1990-10-16 | Abbott Laboratories | Dopamine agonists |
IL131243A (en) * | 1997-02-07 | 2004-02-19 | Aventis Pharma Inc | History - (4 Piperidinyl) - 2-1H - Benzofiran, their preparation and pharmaceutical preparations containing them |
US6004982A (en) * | 1997-09-15 | 1999-12-21 | Hoechst Marion Roussel, Inc. | 4-piperidinyl) H-2-benzopyran derivatives useful as antipsychotic agents |
-
2005
- 2005-04-27 PT PT05740005T patent/PT1749001E/pt unknown
- 2005-04-27 AT AT05740005T patent/ATE459618T1/de active
- 2005-04-27 ES ES05740005T patent/ES2342083T3/es active Active
- 2005-04-27 JP JP2007510941A patent/JP4685861B2/ja not_active Expired - Fee Related
- 2005-04-27 WO PCT/US2005/014487 patent/WO2005111025A1/en not_active Application Discontinuation
- 2005-04-27 DK DK05740005.3T patent/DK1749001T3/da active
- 2005-04-27 DE DE602005019719T patent/DE602005019719D1/de active Active
- 2005-04-27 EP EP05740005A patent/EP1749001B1/en active Active
- 2005-04-28 AR ARP050101668A patent/AR050245A1/es not_active Application Discontinuation
- 2005-04-29 TW TW094113776A patent/TW200607802A/zh unknown
-
2006
- 2006-10-24 US US11/552,169 patent/US7919508B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20070099955A1 (en) | 2007-05-03 |
ES2342083T3 (es) | 2010-07-01 |
DK1749001T3 (da) | 2010-06-28 |
DE602005019719D1 (de) | 2010-04-15 |
EP1749001B1 (en) | 2010-03-03 |
JP4685861B2 (ja) | 2011-05-18 |
PT1749001E (pt) | 2010-05-31 |
JP2007535548A (ja) | 2007-12-06 |
ATE459618T1 (de) | 2010-03-15 |
TW200607802A (en) | 2006-03-01 |
EP1749001A1 (en) | 2007-02-07 |
US7919508B2 (en) | 2011-04-05 |
WO2005111025A1 (en) | 2005-11-24 |
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