AR048971A1 - Composicion para sensibilizacion a otra terapia anticancerosa y/o mitigacion de un efecto colateral de otra terapia anticancerosa mediante el tratamiento con un compuesto anticanceroso activado por gst - Google Patents
Composicion para sensibilizacion a otra terapia anticancerosa y/o mitigacion de un efecto colateral de otra terapia anticancerosa mediante el tratamiento con un compuesto anticanceroso activado por gstInfo
- Publication number
- AR048971A1 AR048971A1 ARP050102064A ARP050102064A AR048971A1 AR 048971 A1 AR048971 A1 AR 048971A1 AR P050102064 A ARP050102064 A AR P050102064A AR P050102064 A ARP050102064 A AR P050102064A AR 048971 A1 AR048971 A1 AR 048971A1
- Authority
- AR
- Argentina
- Prior art keywords
- gst
- therapy
- optionally substituted
- compound
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 11
- 238000011319 anticancer therapy Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000000694 effects Effects 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 2
- 206010070834 Sensitisation Diseases 0.000 title 1
- 230000000116 mitigating effect Effects 0.000 title 1
- 230000008313 sensitization Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 abstract 7
- 241000124008 Mammalia Species 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001235 sensitizing effect Effects 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 241000219198 Brassica Species 0.000 abstract 1
- 235000003351 Brassica cretica Nutrition 0.000 abstract 1
- 235000003343 Brassica rupestris Nutrition 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- 229940000635 beta-alanine Drugs 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000001815 biotherapy Methods 0.000 abstract 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 abstract 1
- OJLHWPALWODJPQ-QNWVGRARSA-N canfosfamide Chemical compound ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 OJLHWPALWODJPQ-QNWVGRARSA-N 0.000 abstract 1
- 229950000772 canfosfamide Drugs 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- ANCLJVISBRWUTR-UHFFFAOYSA-N diaminophosphinic acid Chemical compound NP(N)(O)=O ANCLJVISBRWUTR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- 125000002642 gamma-glutamyl group Chemical group 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 238000009126 molecular therapy Methods 0.000 abstract 1
- 235000010460 mustard Nutrition 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El uso de un compuesto anticanceroso activado por GST en la elaboracion de un medicamento para sensibilizar a un mamífero, especialmente un humano, a otra terapia anticancerosa (es decir, una terapia anticancerosa que no es un tatamiento con un compuesto anticanceroso activado por la GST- incluyendo quimioterapia, terapia molecular focalizada, terapia biologica y radioterapia, utilizado como monoterapia o en combinacion) o para mitigar un efecto colateral de otra terapia anticancerosa en un mamífero, especialmente un humano. Composiciones que contienen un compuesto anticanceroso activado por GST para estos usos. Un método para sensibilizar a un mamífero, especialmente un humano, mediante la administracion de una cantidad efectiva para sensibilizar de un compuesto anticanceroso activado opor GST. Un método para mitigar un efecto colateral de otra terapia anticancerosa en un mamífero, especialmente un humano, mediante la administracion de una cantidad efectiva para sensibilizar de un compuesto anticanceroso activado por GST. El compuesto anticanceroso activado por GST es preferentemente un compuesto segun la Patente de los Estados Unidos No. 5.556.942, y más preferentemente canfosfamida, especialmente la sal de clorhidrato. Reivindicacion 27: La composicion de acuerdo con la reivindicacion 26, en la cual el compuesto anticanceroso activado por GST es un compuesto de la formula (1) o una amida, éster, amida-éster o sal del mismo, donde: L es un grupo saliente citotoxico tomador de electrones; Sx es -S(=O)-, -S(=O)2-, -S(=NH)-, -S(=O)(=NH)-, -S+(alquilo C1-6)-, -Se(=O)-, -Se(=O)2-, -Se(=NH)-, o -Se(=O)(=NH)-, o es -O-C(=O)- o -HN-C(=O)-; cada R1, R2 y R3 es independientemente H o un sustituyente que no interfiere; n es 0, 1 o 2; Y es seleccionado del grupo constituido por el grupo de formulas (2) donde m es 1 o 2 yAAc es un aminoácido ligado a través de un enlace peptídico al resto del compuesto. Reivindicacion 28: La composicion de acuerdo con la reivindicacion 27, en la cual: cada R1, R2 y R3 es independientemente H, alquilo C1-6 optativamente susttituido, arilo C6-12 optativamente sustituido, aralquilo C7-12 optativamente sustituido, ciano, halo, alcoxi C1-6 optativamente sustituido, ariloxi C6-12 optativamente sustituido o aralcoxi C7-12 optativamente sustituido, donde los sustituyentes pueden ser halo, -OR, -SR y NR2, donde R es H o alquilo C1-4. Reivindicacion 29: La composicion de acuerdo con la reivindicacion 27, en la cual: L es una toxina, un agente anticanceroso ligable o una mostaza de fosforamidato o fosforodiamidato, y/o Sx es -S(=O)2-; y/o R1 es H, alquilo C1-4 o fenilo, y/o cada R2 es independientemente seleccionado entre H y alquilo C1-6; y/o cada R3 es independientemente seleccionado entre H, alquilo C1-4 y fenilo; y/o n es 0; y/o Y-C(=O)- es gamma-glutamilo; y/o AAc es glicina, fenilglicina, beta-alanina, alanina, fenilalanina, valina, ácido 4-aminobutírico, ácido aspártico, histidina, triptofano y tirosina, como isomeros (S) o (R), optativamente sustituidos en el anillo de fenilo de acuerdo con lo descripto anteriormente para R1 a R3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57279004P | 2004-05-20 | 2004-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR048971A1 true AR048971A1 (es) | 2006-06-14 |
Family
ID=34970551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050102064A AR048971A1 (es) | 2004-05-20 | 2005-05-19 | Composicion para sensibilizacion a otra terapia anticancerosa y/o mitigacion de un efecto colateral de otra terapia anticancerosa mediante el tratamiento con un compuesto anticanceroso activado por gst |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20050261202A1 (es) |
| EP (1) | EP1755632A1 (es) |
| JP (1) | JP2007538105A (es) |
| KR (1) | KR101174685B1 (es) |
| CN (1) | CN1953762B (es) |
| AR (1) | AR048971A1 (es) |
| AU (1) | AU2005245004B2 (es) |
| BR (1) | BRPI0511296A (es) |
| CA (1) | CA2566850A1 (es) |
| MX (1) | MXPA06013375A (es) |
| TW (1) | TW200538149A (es) |
| WO (1) | WO2005112973A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| TW200538149A (en) | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
| CU23511B6 (es) * | 2006-02-28 | 2010-04-13 | Biorec B V | Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas |
| ES2293834B1 (es) | 2006-07-20 | 2009-02-16 | Consejo Superior Investig. Cientificas | Compuesto con actividad inhibidora de las interacciones ubc13-uev, composiciones farmaceuticas que lo comprenden y sus aplicaciones terapeuticas. |
| US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| US8168661B2 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
| EP2091914A4 (en) * | 2006-11-08 | 2010-12-29 | Chongxi Yu | TRANSDERMAL ADMINISTRATION SYSTEMS FOR PEPTIDES AND RELATED CONNECTIONS |
| US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
| PT2136631E (pt) * | 2007-04-14 | 2012-09-27 | Southern Res Inst | Processos para tratamento da neoplasia com associação de agentes quimioterapêuticos e radiação |
| US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| WO2009011861A1 (en) * | 2007-07-16 | 2009-01-22 | Poniard Pharmaceuticals, Inc. | Oral formulations for picoplatin |
| AU2008325243B2 (en) * | 2007-11-02 | 2014-07-03 | Solasia Pharma K.K. | Combination therapy with organic arsenicals |
| ES2332167B1 (es) | 2007-12-04 | 2010-10-25 | Universidad Autonoma De Madrid | Empleo de trefoil factor-family 3 (tff3) en el pronostico de sujetos diagnosticados con cancer colorectal. |
| ES2332557B1 (es) | 2007-12-04 | 2011-02-02 | Universidad Autonoma De Madrid | Huella genomica para el pronostico de la evolucion de adenocarcinoma colorectal. |
| WO2009099634A2 (en) * | 2008-02-08 | 2009-08-13 | Poniard Pharmaceuticals, Inc. | Picoplatin and amrubicin to treat lung cancer |
| ES2476602T3 (es) * | 2008-03-14 | 2014-07-15 | Bionumerik Pharmaceuticals, Inc. | Composiciones y métodos quimioprotectores |
| ES2338843B1 (es) | 2008-07-02 | 2011-01-24 | Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas | Huella genomica de cancer de mama. |
| EP2169078A1 (en) | 2008-09-26 | 2010-03-31 | Fundacion Gaiker | Methods and kits for the diagnosis and the staging of colorectal cancer |
| CN109232716A (zh) | 2009-05-08 | 2019-01-18 | 上海泰飞尔生化技术有限公司 | 多肽和多肽相关化合物的高穿透力前药组合物 |
| CN106177963A (zh) * | 2009-06-05 | 2016-12-07 | 陶制药有限责任公司 | 用于治疗癌症或癌前病症的交错方法 |
| JP6017964B2 (ja) | 2010-03-01 | 2016-11-02 | ティーエーユー・セラピューティクス・エルエルシー | 癌診断および撮像 |
| US20120251496A1 (en) * | 2011-03-31 | 2012-10-04 | Telik, Inc. | Ezatiostat for treating multiple myeloma |
| US20120288554A1 (en) * | 2011-05-12 | 2012-11-15 | Telik, Inc. | Canfosfamide monotherapy for treating multiple myeloma |
| WO2013092960A1 (en) | 2011-12-22 | 2013-06-27 | Fundacion Gaiker | Methods and kits for the diagnosis of colorectal cancer |
| CA2880896C (en) | 2012-06-26 | 2021-11-16 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| US11491154B2 (en) | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| ES2899211T3 (es) | 2014-06-17 | 2022-03-10 | Nitto Denko Corp | Inhibidores de GST-pi y RB1CC1 para su uso en el tratamiento de cáncer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5767147A (en) * | 1995-04-21 | 1998-06-16 | The Regents Of The University Of California | Inhibition of glutathione transferase by haloenol lactones |
| AU715524B2 (en) | 1995-06-07 | 2000-02-03 | Telik, Inc. | Metabolic effects of certain glutathione analogs |
| US5880097A (en) * | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
| US6281223B1 (en) * | 1999-04-13 | 2001-08-28 | Supergen, Inc. | Radioenhanced camptothecin derivative cancer treatments |
| TWI323662B (en) * | 2002-11-15 | 2010-04-21 | Telik Inc | Combination cancer therapy with a gst-activated anticancer compound and another anticancer therapy |
| TW200538149A (en) | 2004-05-20 | 2005-12-01 | Telik Inc | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound |
-
2005
- 2005-05-10 TW TW094115086A patent/TW200538149A/zh unknown
- 2005-05-19 CA CA002566850A patent/CA2566850A1/en not_active Abandoned
- 2005-05-19 US US11/133,833 patent/US20050261202A1/en not_active Abandoned
- 2005-05-19 CN CN2005800158989A patent/CN1953762B/zh not_active Expired - Fee Related
- 2005-05-19 MX MXPA06013375A patent/MXPA06013375A/es active IP Right Grant
- 2005-05-19 BR BRPI0511296-6A patent/BRPI0511296A/pt not_active IP Right Cessation
- 2005-05-19 WO PCT/US2005/017960 patent/WO2005112973A1/en active Application Filing
- 2005-05-19 EP EP05752058A patent/EP1755632A1/en not_active Withdrawn
- 2005-05-19 JP JP2007527521A patent/JP2007538105A/ja active Pending
- 2005-05-19 AU AU2005245004A patent/AU2005245004B2/en not_active Ceased
- 2005-05-19 AR ARP050102064A patent/AR048971A1/es not_active Application Discontinuation
-
2006
- 2006-12-08 KR KR1020067025870A patent/KR101174685B1/ko not_active IP Right Cessation
-
2007
- 2007-10-15 US US11/872,662 patent/US8207121B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8207121B2 (en) | 2012-06-26 |
| KR101174685B1 (ko) | 2012-08-16 |
| EP1755632A1 (en) | 2007-02-28 |
| US20050261202A1 (en) | 2005-11-24 |
| AU2005245004B2 (en) | 2011-08-04 |
| AU2005245004A1 (en) | 2005-12-01 |
| WO2005112973A1 (en) | 2005-12-01 |
| MXPA06013375A (es) | 2007-03-01 |
| CN1953762B (zh) | 2012-04-25 |
| TW200538149A (en) | 2005-12-01 |
| CN1953762A (zh) | 2007-04-25 |
| US20080166428A1 (en) | 2008-07-10 |
| CA2566850A1 (en) | 2005-12-01 |
| BRPI0511296A (pt) | 2007-12-04 |
| KR20070012542A (ko) | 2007-01-25 |
| JP2007538105A (ja) | 2007-12-27 |
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