AR044492A1 - Metodos de deteccion de la enfermedad de alzheimer - Google Patents
Metodos de deteccion de la enfermedad de alzheimerInfo
- Publication number
- AR044492A1 AR044492A1 ARP040101994A ARP040101994A AR044492A1 AR 044492 A1 AR044492 A1 AR 044492A1 AR P040101994 A ARP040101994 A AR P040101994A AR P040101994 A ARP040101994 A AR P040101994A AR 044492 A1 AR044492 A1 AR 044492A1
- Authority
- AR
- Argentina
- Prior art keywords
- polymorphism
- lines
- indifferent
- minor allele
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Métodos de diagnóstico o pronóstico de la enfermedad de Alzheimer en un sujeto. Dicho método comprende al menos una etapa de detección de la presencia o la ausencia del alelo minoritario del polimorfismo rs908832 del gen ABCA2. La presencia del alelo minoritario del polimorfismo rs908832 del gen ABCA2 indica que el sujeto puede padecer la enfermedad de Alzheimer o bien presentar un riesgo aumentado de desarrollar la enfermedad de Alzheimer. Reivindicación 15: Cebo, que permite la amplificación del alelo minoritario del polimorfismo rs908832. Reivindicación 21: Sonda según la reivindicación 20, caracterizada porque presenta la secuencia SEQ ID Nº 8. Reivindicación 27: Animales transgénicos, líneas de tejidos indiferentes y líneas celulares diferenciales a partir de estas líneas de tejidos indiferentes, en el genoma de las cuales está insertada al menos una secuencia de ADN exógeno genómico que porta el alelo minoritario del polimorfismo rs908832 del gen ABCA2. Reivindicación 29: Procedimiento de obtención de animales transgénicos, líneas de tejidos indiferentes y líneas de células diferenciadas a partir de estas líneas de tejidos indiferentes, según una de las reivindicaciones 27 y 28, caracterizado porque comprende la generación de animales transgénicos, de líneas de tejidos indiferentes y de líneas de células diferenciadas a partir de estas líneas de tejidos indiferentes, que comprenden el alelo minoritario del polimorfismo rs908832 del gen ABCA2 humano. Reivindicación 31: Célula extraída de animales transgénicos, como se describe en una de las reivindicaciones 27 y 28.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0307501A FR2856409B1 (fr) | 2003-06-20 | 2003-06-20 | Methodes de detection de la maladie d'alzheimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044492A1 true AR044492A1 (es) | 2005-09-14 |
Family
ID=33484616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101994A AR044492A1 (es) | 2003-06-20 | 2004-06-09 | Metodos de deteccion de la enfermedad de alzheimer |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1639139B1 (es) |
| JP (1) | JP4691491B2 (es) |
| KR (1) | KR101170651B1 (es) |
| CN (1) | CN1809645B (es) |
| AR (1) | AR044492A1 (es) |
| AT (1) | ATE518005T1 (es) |
| AU (1) | AU2004249919B2 (es) |
| BR (1) | BRPI0411658A (es) |
| CA (1) | CA2529633C (es) |
| CY (1) | CY1111970T1 (es) |
| DK (1) | DK1639139T3 (es) |
| ES (1) | ES2370491T3 (es) |
| FR (1) | FR2856409B1 (es) |
| HK (1) | HK1090392A1 (es) |
| HR (1) | HRP20110778T1 (es) |
| IL (1) | IL172690A0 (es) |
| MX (1) | MXPA05012800A (es) |
| NO (1) | NO20060257L (es) |
| PL (1) | PL1639139T3 (es) |
| PT (1) | PT1639139E (es) |
| RU (2) | RU2483108C2 (es) |
| SI (1) | SI1639139T1 (es) |
| TW (1) | TWI352738B (es) |
| WO (1) | WO2004113568A2 (es) |
| ZA (1) | ZA200509945B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103013989A (zh) * | 2011-09-23 | 2013-04-03 | 深圳北京大学香港科技大学医学中心 | 与老年痴呆症发病相关的细胞周期依赖性激酶5的单核苷酸多态性位点 |
| GB201212084D0 (en) * | 2012-07-06 | 2012-08-22 | Randox Lab Ltd | Tropomyosin isoforms related to alzheimers disease and mild cognitive impairment |
| CN102768189B (zh) * | 2012-07-30 | 2014-11-19 | 黄石 | 一种药物筛选方法 |
| CN104313144B (zh) * | 2014-10-16 | 2017-02-01 | 卫生部北京医院 | 一种检测阿尔茨海默病易感性的试剂 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5853995A (en) * | 1997-01-07 | 1998-12-29 | Research Development Foundation | Large scale genotyping of diseases and a diagnostic test for spinocerebellar ataxia type 6 |
| EP1210422A2 (en) * | 1999-08-20 | 2002-06-05 | Active Pass Pharmaceuticals, Inc. | Human abc2 transporter and uses thereof |
| AU7699501A (en) * | 2000-07-20 | 2002-02-05 | Cephalon Inc | Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring |
| JP2004147502A (ja) * | 2000-07-26 | 2004-05-27 | Banyu Pharmaceut Co Ltd | ヒト及びラットａｂｃａ２遺伝子 |
| WO2002064781A2 (en) * | 2001-02-09 | 2002-08-22 | Active Pass Pharmaceuticals, Inc. | Regulation of amyloid precursor protein expression by modification of abc transporter expression or activity |
| AU2002304931A1 (en) * | 2001-06-08 | 2002-12-23 | University Of British Columbia | Methods for treating disorders of the nervous and reproductive systems |
-
2003
- 2003-06-20 FR FR0307501A patent/FR2856409B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-09 AR ARP040101994A patent/AR044492A1/es active IP Right Grant
- 2004-06-17 KR KR1020057024490A patent/KR101170651B1/ko not_active IP Right Cessation
- 2004-06-17 BR BRPI0411658-5A patent/BRPI0411658A/pt not_active IP Right Cessation
- 2004-06-17 CA CA2529633A patent/CA2529633C/fr not_active Expired - Fee Related
- 2004-06-17 AT AT04767370T patent/ATE518005T1/de active
- 2004-06-17 SI SI200431759T patent/SI1639139T1/sl unknown
- 2004-06-17 EP EP04767370A patent/EP1639139B1/fr not_active Expired - Lifetime
- 2004-06-17 JP JP2006516300A patent/JP4691491B2/ja not_active Expired - Fee Related
- 2004-06-17 AU AU2004249919A patent/AU2004249919B2/en not_active Ceased
- 2004-06-17 PL PL04767370T patent/PL1639139T3/pl unknown
- 2004-06-17 CN CN2004800172750A patent/CN1809645B/zh not_active Expired - Fee Related
- 2004-06-17 DK DK04767370.2T patent/DK1639139T3/da active
- 2004-06-17 RU RU2009104533/10A patent/RU2483108C2/ru not_active IP Right Cessation
- 2004-06-17 WO PCT/FR2004/001509 patent/WO2004113568A2/fr active Application Filing
- 2004-06-17 MX MXPA05012800A patent/MXPA05012800A/es active IP Right Grant
- 2004-06-17 RU RU2006101561/13A patent/RU2380423C2/ru not_active IP Right Cessation
- 2004-06-17 PT PT04767370T patent/PT1639139E/pt unknown
- 2004-06-17 ES ES04767370T patent/ES2370491T3/es not_active Expired - Lifetime
- 2004-06-18 TW TW093117572A patent/TWI352738B/zh not_active IP Right Cessation
-
2005
- 2005-12-07 ZA ZA200509945A patent/ZA200509945B/en unknown
- 2005-12-19 IL IL172690A patent/IL172690A0/en not_active IP Right Cessation
-
2006
- 2006-01-18 NO NO20060257A patent/NO20060257L/no not_active Application Discontinuation
- 2006-10-10 HK HK06111103.5A patent/HK1090392A1/xx not_active IP Right Cessation
-
2011
- 2011-10-26 HR HR20110778T patent/HRP20110778T1/hr unknown
- 2011-10-27 CY CY20111101024T patent/CY1111970T1/el unknown
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Legal Events
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