AR042354A1 - Aplicacion de inhibidores de recaptura intestinal del acido biliar para la prevencion y el tratamiento de la enfermedad de alzheimer - Google Patents
Aplicacion de inhibidores de recaptura intestinal del acido biliar para la prevencion y el tratamiento de la enfermedad de alzheimerInfo
- Publication number
- AR042354A1 AR042354A1 ARP030104540A ARP030104540A AR042354A1 AR 042354 A1 AR042354 A1 AR 042354A1 AR P030104540 A ARP030104540 A AR P030104540A AR P030104540 A ARP030104540 A AR P030104540A AR 042354 A1 AR042354 A1 AR 042354A1
- Authority
- AR
- Argentina
- Prior art keywords
- alzheimer
- disease
- prevention
- treatment
- application
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 5
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 230000000968 intestinal effect Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- 235000012000 cholesterol Nutrition 0.000 abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0215722A FR2848452B1 (fr) | 2002-12-12 | 2002-12-12 | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042354A1 true AR042354A1 (es) | 2005-06-15 |
Family
ID=32338722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030104540A AR042354A1 (es) | 2002-12-12 | 2003-12-10 | Aplicacion de inhibidores de recaptura intestinal del acido biliar para la prevencion y el tratamiento de la enfermedad de alzheimer |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1572174A1 (enExample) |
| JP (1) | JP2006514063A (enExample) |
| KR (1) | KR20050084250A (enExample) |
| CN (1) | CN1726016A (enExample) |
| AR (1) | AR042354A1 (enExample) |
| AU (1) | AU2003296802A1 (enExample) |
| BR (1) | BR0317280A (enExample) |
| CA (1) | CA2507945A1 (enExample) |
| CO (1) | CO5700712A2 (enExample) |
| FR (1) | FR2848452B1 (enExample) |
| HR (1) | HRP20050534A2 (enExample) |
| MA (1) | MA27500A1 (enExample) |
| MX (1) | MXPA05005556A (enExample) |
| NO (1) | NO20053341L (enExample) |
| NZ (1) | NZ540496A (enExample) |
| PE (1) | PE20040770A1 (enExample) |
| PL (1) | PL377110A1 (enExample) |
| RS (1) | RS20050420A (enExample) |
| RU (1) | RU2005121909A (enExample) |
| TW (1) | TW200503707A (enExample) |
| WO (1) | WO2004062652A1 (enExample) |
| ZA (1) | ZA200504656B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| WO2005049027A2 (en) | 2003-11-03 | 2005-06-02 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| JP4996926B2 (ja) | 2004-02-05 | 2012-08-08 | プロビオドルグ エージー | グルタミニルシクラーゼの新規の阻害剤 |
| CA2589102C (en) | 2004-11-02 | 2013-08-13 | Northwestern University | Pyridazine compounds and methods for using the compounds to treat inflammatory diseases |
| CA2650711A1 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| KR101441725B1 (ko) * | 2007-05-22 | 2014-09-18 | 오츠카 세이야쿠 가부시키가이샤 | 알츠하이머병 치료를 위한 카르보스티릴 유도체 및 도네페질을 포함하는 치료제 |
| DK2771003T3 (en) | 2011-10-28 | 2017-07-17 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for the treatment of pediatric cholestatic liver disease |
| US20140323412A1 (en) * | 2011-10-28 | 2014-10-30 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2040996A1 (en) * | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
| JPH06502184A (ja) * | 1991-02-22 | 1994-03-10 | シャピロ，ハワード ケイ． | 神経性疾病の症候や原因上関係のある症候の治療のための薬用化合物の使用 |
| EP0907666A1 (en) * | 1996-06-27 | 1999-04-14 | G.D. Searle & Co. | Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications |
| US5985936A (en) * | 1997-12-18 | 1999-11-16 | Forbes Medi-Tech, Inc. | Method of preventing and delaying onset of Alzheimer's disease and composition therefor |
| JP2002501887A (ja) * | 1998-01-28 | 2002-01-22 | ワーナー−ランバート・カンパニー | アルツハイマー病の治療方法 |
| US6080778A (en) * | 1998-03-23 | 2000-06-27 | Children's Medical Center Corporation | Methods for decreasing beta amyloid protein |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19825804C2 (de) * | 1998-06-10 | 2000-08-24 | Aventis Pharma Gmbh | 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE19845405C2 (de) * | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| WO2001056579A1 (en) * | 2000-02-04 | 2001-08-09 | Esperion Therapeutics Inc. | Methods for treating alzheimer's disease |
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| TWI329111B (en) * | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
-
2002
- 2002-12-12 FR FR0215722A patent/FR2848452B1/fr not_active Expired - Fee Related
-
2003
- 2003-12-10 BR BR0317280-5A patent/BR0317280A/pt not_active IP Right Cessation
- 2003-12-10 AR ARP030104540A patent/AR042354A1/es not_active Application Discontinuation
- 2003-12-10 PE PE2003001247A patent/PE20040770A1/es not_active Application Discontinuation
- 2003-12-10 KR KR1020057010595A patent/KR20050084250A/ko not_active Withdrawn
- 2003-12-10 RU RU2005121909/15A patent/RU2005121909A/ru not_active Application Discontinuation
- 2003-12-10 JP JP2004566119A patent/JP2006514063A/ja not_active Abandoned
- 2003-12-10 RS YUP-2005/0420A patent/RS20050420A/sr unknown
- 2003-12-10 EP EP03815109A patent/EP1572174A1/fr not_active Withdrawn
- 2003-12-10 MX MXPA05005556A patent/MXPA05005556A/es not_active Application Discontinuation
- 2003-12-10 CA CA002507945A patent/CA2507945A1/fr not_active Abandoned
- 2003-12-10 HR HR20050534A patent/HRP20050534A2/xx not_active Application Discontinuation
- 2003-12-10 CN CNA2003801059727A patent/CN1726016A/zh active Pending
- 2003-12-10 PL PL377110A patent/PL377110A1/pl not_active Application Discontinuation
- 2003-12-10 WO PCT/FR2003/003654 patent/WO2004062652A1/fr not_active Ceased
- 2003-12-10 NZ NZ540496A patent/NZ540496A/en unknown
- 2003-12-10 AU AU2003296802A patent/AU2003296802A1/en not_active Abandoned
- 2003-12-11 TW TW092134949A patent/TW200503707A/zh unknown
-
2005
- 2005-06-07 ZA ZA200504656A patent/ZA200504656B/en unknown
- 2005-06-09 CO CO05056010A patent/CO5700712A2/es not_active Application Discontinuation
- 2005-06-10 MA MA28329A patent/MA27500A1/fr unknown
- 2005-07-08 NO NO20053341A patent/NO20053341L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RS20050420A (sr) | 2007-04-10 |
| MA27500A1 (fr) | 2005-08-01 |
| FR2848452A1 (fr) | 2004-06-18 |
| HRP20050534A2 (en) | 2006-11-30 |
| TW200503707A (en) | 2005-02-01 |
| WO2004062652A1 (fr) | 2004-07-29 |
| NZ540496A (en) | 2008-04-30 |
| RU2005121909A (ru) | 2006-01-20 |
| MXPA05005556A (es) | 2005-07-26 |
| EP1572174A1 (fr) | 2005-09-14 |
| CN1726016A (zh) | 2006-01-25 |
| BR0317280A (pt) | 2005-11-08 |
| CA2507945A1 (fr) | 2004-07-29 |
| AU2003296802A1 (en) | 2004-08-10 |
| NO20053341D0 (no) | 2005-07-08 |
| PE20040770A1 (es) | 2004-12-10 |
| FR2848452B1 (fr) | 2007-04-06 |
| JP2006514063A (ja) | 2006-04-27 |
| ZA200504656B (en) | 2006-08-30 |
| CO5700712A2 (es) | 2006-11-30 |
| KR20050084250A (ko) | 2005-08-26 |
| NO20053341L (no) | 2005-09-07 |
| PL377110A1 (pl) | 2006-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT1509232E (pt) | Uma combinação de um antagonista de nmda e inibidores da acetilcolina esterase para o tratamento da doença de alzheimer | |
| NO20050795L (no) | Forbindelser, blandinger og fremgangsmater for utnyttelse av samme | |
| GB0223040D0 (en) | Therapeutic compounds | |
| BRPI0413363A (pt) | formas de dosagem fornecendo liberação controlada de inibidores de proteìna de transferência de ésteres de colesterila e liberação imediata de inibidores de hmg-coa redutase | |
| EP1474139A4 (en) | 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 HEMMER FOR THE TREATMENT OF DIABETES, ADIPOSITAS AND DYSLIPIDEMIA | |
| DK1663978T3 (da) | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser | |
| NO20044195L (no) | Biofosfoninsyrer for behandling og prevensjon av osteoprose | |
| EP1522314A4 (en) | MEDICINAL PRODUCTS FOR DISEASES CAUSED BY VASCULAR CONTRACTION OR DILATION | |
| ATE416761T1 (de) | Prävention und behandlung von durch entzündung ausgelöstem und/oder immunvermitteltem knochenschwund | |
| DK1487541T3 (da) | Anvendelse af IL-18-inhibitorer til behandling og/eller forebyggelse af perifere vaskulære sygdomme | |
| ATE554084T1 (de) | N-hydroxyacrylamidverbindungen | |
| EA200900073A1 (ru) | КОМБИНАЦИЯ ИНГИБИТОРОВ HMG-CoA-РЕДУКТАЗЫ И ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ 4, ПРЕДНАЗНАЧЕННАЯ ДЛЯ ЛЕЧЕНИЯ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ЛЕГКИХ | |
| BR0316723A (pt) | Derivados de anilinopirazol úteis para o tratamento de diabetes | |
| NO20044898L (no) | Nye etonogestrel estere | |
| DK1648484T3 (da) | Fremgangsmåde til behandling af arthritis-tilstande | |
| EA200501479A1 (ru) | Ifn-бета в отдельности или в комбинации с другими лекарственными средствами для лечения болезни альцгеймера и нарушений, связанных с деменцией | |
| AR042354A1 (es) | Aplicacion de inhibidores de recaptura intestinal del acido biliar para la prevencion y el tratamiento de la enfermedad de alzheimer | |
| MY147175A (en) | Method for preventing or treating the development of respiratory allergies | |
| IS8004A (is) | Aðferð við meðhöndlun á vægri vitsmunaskerðingu og til að fyrirbyggja eða tefja Alzheimers-sjúkdóminn | |
| NO20063963L (no) | Multipartikulaere 0-desmetylvenlafaksinsalter og anvendelser derav | |
| EA200702212A1 (ru) | Способ лечения или профилактики разрушения кости или остеопороза | |
| TW200806293A (en) | Methods of treatment with CETP inhibitors | |
| ATE410235T1 (de) | Behandlung von ballastwasser | |
| ATE392212T1 (de) | Verwendung eines proteasom-inhibitors zur behandlung fibrotischer erkrankungen | |
| UA85187C2 (en) | 2-aminobenzoyl derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |