AR042335A1 - Derivados de nucleosido antivirales - Google Patents

Derivados de nucleosido antivirales

Info

Publication number
AR042335A1
AR042335A1 ARP030104519A ARP030104519A AR042335A1 AR 042335 A1 AR042335 A1 AR 042335A1 AR P030104519 A ARP030104519 A AR P030104519A AR P030104519 A ARP030104519 A AR P030104519A AR 042335 A1 AR042335 A1 AR 042335A1
Authority
AR
Argentina
Prior art keywords
nucleoside derivatives
cor4
hepatitis
treatment
antiviral nucleoside
Prior art date
Application number
ARP030104519A
Other languages
English (en)
Inventor
Robert Than Hendricks
Eric Roy Humphreys
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR042335A1 publication Critical patent/AR042335A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente se refiere a derivados de nucleósido para el tratamiento de infecciones del virus de la Hepatitis C. Composiciones farmacéuticas que comprenden estos compuestos y métodos para el tratamiento o profilaxis de enfermedades mediadas del virus de la Hepatitis C que emplean dichos compuestos en monoterapia o en terapia de combinación. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1) en donde R1, R2, y R3 se seleccionan independientemente el grupo que consiste de H, acilo C1-10, alcoxicarbonilo C1-10 y COR4 donde COR4 es un aminoácido o un dipéptido; e hidratos, solvatos, clatratos de dicho compuesto y sales de adición ácida.
ARP030104519A 2002-12-10 2003-12-09 Derivados de nucleosido antivirales AR042335A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43210802P 2002-12-10 2002-12-10

Publications (1)

Publication Number Publication Date
AR042335A1 true AR042335A1 (es) 2005-06-15

Family

ID=32507851

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104519A AR042335A1 (es) 2002-12-10 2003-12-09 Derivados de nucleosido antivirales

Country Status (12)

Country Link
US (1) US20040121969A1 (es)
EP (1) EP1572710A2 (es)
JP (1) JP2006510645A (es)
CN (1) CN1742018A (es)
AR (1) AR042335A1 (es)
AU (1) AU2003296601A1 (es)
CA (1) CA2508656A1 (es)
GT (1) GT200300275A (es)
PA (1) PA8590801A1 (es)
PE (1) PE20040903A1 (es)
TW (1) TW200417372A (es)
WO (1) WO2004052905A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0310593D0 (en) * 2003-05-08 2003-06-11 Leuven K U Res & Dev Peptidic prodrugs
EP1668022A1 (en) * 2003-09-11 2006-06-14 F.Hoffmann-La Roche Ag Process for preparing antiviral nucleoside derivatives
WO2005023826A2 (en) * 2003-09-11 2005-03-17 F.Hoffmann-La Roche Ag Polymorphic nucleoside compounds
FR2869616B1 (fr) * 2004-04-29 2008-10-24 Univ D Avignon Et Des Pays Du Nouveaux composes amphiphiles, leur procede de preparation et leurs applications notamment a la transfection
SI3109244T1 (sl) * 2004-09-14 2019-06-28 Gilead Pharmasset Llc Priprava 2'fluoro-2'-alkil-substituiranih ali drugih neobvezno substituiranih ribofuranozil pirimidinov in purinov in njihovih derivatov
US8466276B2 (en) 2008-02-22 2013-06-18 Nektar Therapeutics Oligomer conjugates of heteropentacyclic nucleosides
EP2113508A1 (en) * 2008-04-30 2009-11-04 INSERM (Institut National de la Santé et de la Recherche Medicale) Novel triazole nucleoside derivatives, their preparation and their application in therapeutics
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
JP6824062B2 (ja) * 2017-02-14 2021-02-03 日本電子株式会社 イオン化法選択支援装置及び方法
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998807A (en) * 1972-03-03 1976-12-21 Syntex (U.S.A.) Inc. Arabinofuranosyl cytosines and methods of making
GB8719367D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
US6184376B1 (en) * 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6518253B1 (en) * 1999-11-19 2003-02-11 Robert Tam Treatment of viral infections using the L-isomer of ribavirin
US6495677B1 (en) * 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds

Also Published As

Publication number Publication date
AU2003296601A1 (en) 2004-06-30
GT200300275A (es) 2004-06-28
PA8590801A1 (es) 2004-11-26
PE20040903A1 (es) 2004-12-02
JP2006510645A (ja) 2006-03-30
WO2004052905A3 (en) 2004-10-14
CA2508656A1 (en) 2004-06-24
US20040121969A1 (en) 2004-06-24
TW200417372A (en) 2004-09-16
WO2004052905A2 (en) 2004-06-24
EP1572710A2 (en) 2005-09-14
AU2003296601A8 (en) 2004-06-30
CN1742018A (zh) 2006-03-01

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