AR039860A1 - 1-tia-3-aza-dibenzoazulenos como inhibidores de la produccion del factor de necrosis tumoral e intermediarios para la preparacion de los mismos - Google Patents
1-tia-3-aza-dibenzoazulenos como inhibidores de la produccion del factor de necrosis tumoral e intermediarios para la preparacion de los mismosInfo
- Publication number
- AR039860A1 AR039860A1 ARP030101802A ARP030101802A AR039860A1 AR 039860 A1 AR039860 A1 AR 039860A1 AR P030101802 A ARP030101802 A AR P030101802A AR P030101802 A ARP030101802 A AR P030101802A AR 039860 A1 AR039860 A1 AR 039860A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- independently
- production
- alkylsulfinyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de 1-tia-3-aza-dibenzoazuleno, sus sales y solvatos farmacológicamente aceptables, procedimientos e intermediarios para la preparación de los mismos, así como también sus efectos antiinflamatorios, en especial para la inhibición de la producción del factor alfa de necrosis tumoral (TNF-alfa) e inhibición de la producción de interleuquina-1 (IL-1), como así también su acción analgésica. Reivindicación 1: Un compuesto de la fórmula (1) caracterizado porque X puede ser CH2 o un heteroátomo como ser O, S, S(=O), S(=O)2, o NRa, donde Ra es H o un grupo protector; Y y Z representan, independientemente uno del otro, uno o más sustituyentes idénticos o diferentes unidos a cualquier átomo de C disponible, y pueden ser halógeno, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, haloalquilo C1-4, hidroxi, alcoxi C1-4, trifluorometoxi, alcanoilo C1-4, amino, aminoalquilo C1-4, N-(alquil-C1-4)amino, N,N-di(alquil-C1-4)amino, tiol, alquiltio, sulfonilo, alquilsulfonilo C1-4, sulfinilo, alquilsulfinilo C1-4, carboxi, alcoxicarbonilo C1-4, ciano,. nitro, R1 puede ser H, halógeno, un alquilo C1-7 o alquenilo C2-7 opcionalmente sustituido, alquinilo C2-7, un arilo o heteroarilo opcionalmente sustituido, y un heterociclo, hidroxi, hidroxialquenilo C2-7, hidroxialquinilo C2-7, alcoxi C1-7, tiol, tioalquenilo C2-7, tioalquinilo C2-7, alquiltio C1-7, aminoalquenilo C2-7, aminoalquinilo C2-7, aminoalcoxi C1-7, alcanoilo C1-7, aroilo, oxoalquilo C1-7, alcanoiloxi C1-7, carboxi, un (alquiloxicarbonilo o ariloxicarbonilo C1-7)opcionalmente sustituido, carbamoilo, N-(alquil C1-7)carbamoilo, N,N-di(alquil C1-7)carbamoilo, ciano, cianoalquilo C1-7, sulfonilo, alquilsulfonilo C1-7, sulfinilo, alquilsulfinilo C1-7, nitro, o un sustituyente de fórmula (2) donde R2 y R3 pueden ser simultáneamente o independientemente uno del otro, H, alquilo C1-4, arilo o conjuntamente con N tener el significado de un heterociclo o heteroarilo opcionalmente sustituido; m representa un entero que oscila entre 1 y 3; n representa un entero que oscila entre 0 y 3; Q1 y Q2 representan, independientemente uno del otro, O, S, o los grupos de fórmulas (3) donde los sustituyentes y1 e y2 pueden ser, independientemente uno del otro, H, halógeno, arilo o alquilo C1-4 opcionalmente sustituido, hidroxi, alcoxi C1-4, alcanoilo C1-4, tiol, alquiltio C1-4, sulfonilo, alquilsulfonilo C1-4, sulfinilo, alquilsulfinilo C1-4, ciano, nitro o conjuntamente forman un grupo carbonilo o imino; así como también sales y solvatos farmacológicamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20020451A HRP20020451A2 (en) | 2002-05-23 | 2002-05-23 | 1-tia-3-aza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039860A1 true AR039860A1 (es) | 2005-03-02 |
Family
ID=29559972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101802A AR039860A1 (es) | 2002-05-23 | 2003-05-23 | 1-tia-3-aza-dibenzoazulenos como inhibidores de la produccion del factor de necrosis tumoral e intermediarios para la preparacion de los mismos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7262302B2 (es) |
| EP (1) | EP1509532A1 (es) |
| JP (1) | JP2005529157A (es) |
| CN (1) | CN1315847C (es) |
| AR (1) | AR039860A1 (es) |
| AU (1) | AU2003232370A1 (es) |
| CA (1) | CA2486821A1 (es) |
| HK (1) | HK1081949A1 (es) |
| HR (1) | HRP20020451A2 (es) |
| IS (1) | IS7566A (es) |
| PL (1) | PL374385A1 (es) |
| RS (1) | RS100004A (es) |
| WO (1) | WO2003099827A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| JP2008532927A (ja) * | 2005-01-13 | 2008-08-21 | グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ | 抗炎症マクロライド接合体 |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| TWI443096B (zh) | 2012-12-18 | 2014-07-01 | Ind Tech Res Inst | ３－（５－（４－（３－氟丙基）哌嗪－１－基）苯並咪唑－２－基）－１－氮雜薁－２－酮之單水合晶型及其製備方法與藥學組成物 |
| CN111107902A (zh) * | 2017-03-14 | 2020-05-05 | 丹娜法伯癌症研究所 | Bax活化的用于诱导细胞死亡的小分子致敏 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711489A (en) | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
| CA967573A (en) | 1972-12-22 | 1975-05-13 | Joseph G. Lombardino | Tetracyclic anti-inflammatory agents |
| US4198421A (en) | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
| HRP20000310A2 (en) * | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
-
2002
- 2002-05-23 HR HR20020451A patent/HRP20020451A2/hr not_active Application Discontinuation
-
2003
- 2003-05-20 WO PCT/HR2003/000023 patent/WO2003099827A1/en active Application Filing
- 2003-05-20 PL PL03374385A patent/PL374385A1/xx not_active Application Discontinuation
- 2003-05-20 AU AU2003232370A patent/AU2003232370A1/en not_active Abandoned
- 2003-05-20 US US10/515,700 patent/US7262302B2/en not_active Expired - Fee Related
- 2003-05-20 EP EP03755235A patent/EP1509532A1/en not_active Withdrawn
- 2003-05-20 RS YU100004A patent/RS100004A/sr unknown
- 2003-05-20 CA CA002486821A patent/CA2486821A1/en not_active Abandoned
- 2003-05-20 CN CNB038161060A patent/CN1315847C/zh not_active Expired - Fee Related
- 2003-05-20 JP JP2004507484A patent/JP2005529157A/ja active Pending
- 2003-05-23 AR ARP030101802A patent/AR039860A1/es unknown
-
2004
- 2004-11-29 IS IS7566A patent/IS7566A/is unknown
-
2006
- 2006-02-17 HK HK06102099A patent/HK1081949A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529157A (ja) | 2005-09-29 |
| WO2003099827A1 (en) | 2003-12-04 |
| CN1665822A (zh) | 2005-09-07 |
| PL374385A1 (en) | 2005-10-17 |
| IS7566A (is) | 2004-11-29 |
| US7262302B2 (en) | 2007-08-28 |
| HK1081949A1 (en) | 2006-05-26 |
| CA2486821A1 (en) | 2003-12-04 |
| AU2003232370A1 (en) | 2003-12-12 |
| RS100004A (en) | 2006-10-27 |
| EP1509532A1 (en) | 2005-03-02 |
| HRP20020451A2 (en) | 2003-12-31 |
| US20060111340A1 (en) | 2006-05-25 |
| CN1315847C (zh) | 2007-05-16 |
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