AR040040A1 - 1,3-diaza-dibenzoazulenos para la inhibicion de la produccion del factor de necrosis tumoral e intermediarios para su preparacion - Google Patents
1,3-diaza-dibenzoazulenos para la inhibicion de la produccion del factor de necrosis tumoral e intermediarios para su preparacionInfo
- Publication number
- AR040040A1 AR040040A1 ARP030101804A ARP030101804A AR040040A1 AR 040040 A1 AR040040 A1 AR 040040A1 AR P030101804 A ARP030101804 A AR P030101804A AR P030101804 A ARP030101804 A AR P030101804A AR 040040 A1 AR040040 A1 AR 040040A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- amino
- alkanoyl
- independently
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Derivados de 1,3 diaza-dibenzoazuleno, sus sales y solvatos farmacológicamente aceptables, procedimientos e intermediarios para la preparación de los mismos, así como también sus efectos antiinflamatorios, en especial para la inhibición de la producción del factor alfa de necrosis tumoral (TNF-alfa) e inhibición de la producción de interleuquina-1 (IL-1), como así también su acción analgésica. Reivindicación 1: Compuestos de fórmula (1) caracterizado porque X puede ser CH2, o un heteroátomo como ser O, S, S(=O), S(=O)2 o NRa, donde Ra es H o un grupo protector; Y y Z representan, independientemente uno del otro, uno o más sustituyentes idénticos o diferentes unidos a cualquier átomo de C disponible, y pueden ser halógeno, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, haloalquilo C1-4, hidroxi, alcoxi C1-4,trifluorometoxi, alcanoilo C1-4, amino, aminoalquilo C1-4, N-(alquil C1-4) amino, N,N-di (alquil-C1-4) amino, tiol, alquiltio C1-4, sulfonilo, alquilsulfonilo C1-4, sulfinilo, alquilsulfinilo C1-4, carboxi, alcoxicarbonilo C1-4, ciano, nitro; R1 puede ser halógeno, hidroxi, alcoxi C1-7, ariloxi, amino, N-(alquil C1-7) amino, N,N-di (alquil C1-7) amino, (alquil C1-7) amino; aminoalcoxi C1-7, alcanoilo C1-7, aroilo, alcanoiloxi C1-7, carboxi, alquiloxicarbonilo o ariloxicarbonilo C1-7 opcionalmente sustituido, carbamoilo, N-(alquil C1-7) carbamoilo, N,N-di (alquil C1-7) carbamoilo, ciano, nitro, o un sustituyente de fórmula (2) donde R3 y R4 pueden ser, simultánea o independientemente uno del otro, H, alquilo C1-4, arilo o conjuntamente con N tener el significado de un heterociclo o heteroarilo opcionalmente sustituido; m representa un entero que oscila entre 1 y 3; n representa un entero que oscila entre 0 y 3; Q1 y Q2 representan independientemente uno del otro, O, S o los grupos; de fórmulas (3) donde los sustituyentes Y1 e Y2 pueden ser, independientemente uno del otro, H, halógeno, arilo o alquilo C1-4 opcionalmente sustituido, hidroxi, alcoxi C1-4, alcanoilo C1-4, tiol, alquiltio C1-4, sulfonilo, alquilsulfonilo C1-4, sulfinilo, alquilsulfinilo C1-4, ciano, nitro, o conjuntamente forman un grupo carbonilo o imino; R2 tiene el significado de H, alquilo C1-7 o arilo opcionalmente sustituido, o un grupo protector; formilo, alcanoilo C1-7, alcoxicarbonilo C1-7, arilalquiloxicarbonilo, aroilo, arilalquilo, alquilsililo C1-7; así como también sales y solvatos farmacológicamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR20020453A HRP20020453A2 (en) | 2002-05-23 | 2002-05-23 | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR040040A1 true AR040040A1 (es) | 2005-03-09 |
Family
ID=29559974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101804A AR040040A1 (es) | 2002-05-23 | 2003-05-23 | 1,3-diaza-dibenzoazulenos para la inhibicion de la produccion del factor de necrosis tumoral e intermediarios para su preparacion |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7166583B2 (es) |
| EP (1) | EP1509528B1 (es) |
| JP (1) | JP2005531586A (es) |
| CN (1) | CN100354277C (es) |
| AR (1) | AR040040A1 (es) |
| AT (1) | ATE409191T1 (es) |
| AU (1) | AU2003232372A1 (es) |
| CA (1) | CA2487017A1 (es) |
| DE (1) | DE60323748D1 (es) |
| ES (1) | ES2314237T3 (es) |
| HR (1) | HRP20020453A2 (es) |
| IS (1) | IS7568A (es) |
| PL (1) | PL374504A1 (es) |
| RS (1) | RS100104A (es) |
| WO (1) | WO2003099823A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4454859B2 (ja) | 1998-11-13 | 2010-04-21 | イミュネックス・コーポレーション | ヒトｔｓｌｐｄｎａおよびポリペプチド |
| WO2003032898A2 (en) | 2001-07-23 | 2003-04-24 | Immunex Corporation | Modified human thymic stromal lymphopoietin |
| HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| EP1793856A2 (en) * | 2004-08-20 | 2007-06-13 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
| US20080096830A1 (en) * | 2005-01-13 | 2008-04-24 | Mladen Mercep | Anti-Inflammatory Macrolide Conjugates |
| US20090286772A1 (en) * | 2006-02-24 | 2009-11-19 | Anh Chau | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
| FR2211218A1 (en) * | 1972-12-21 | 1974-07-19 | Pfizer | Dibenzocyclooctaimidazoles - useful as anti inflammatories |
| US4215135A (en) * | 1979-06-08 | 1980-07-29 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles |
| US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
| US4305954A (en) * | 1981-02-11 | 1981-12-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones |
| US5166214A (en) | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
| CA2003283A1 (en) | 1988-12-05 | 1990-06-05 | C. Anne Higley | Imidazoles for the treatment of atherosclerosis |
| EP1028954B1 (en) | 1997-04-24 | 2003-07-02 | Ortho-McNeil Pharmaceutical, Inc. | Substituted imidazoles useful in the treatment of inflammatory diseases |
| HRP20000310A2 (en) | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
-
2002
- 2002-05-23 HR HR20020453A patent/HRP20020453A2/hr not_active Application Discontinuation
-
2003
- 2003-05-20 CA CA002487017A patent/CA2487017A1/en not_active Abandoned
- 2003-05-20 CN CNB038161214A patent/CN100354277C/zh not_active Expired - Fee Related
- 2003-05-20 PL PL03374504A patent/PL374504A1/xx not_active Application Discontinuation
- 2003-05-20 DE DE60323748T patent/DE60323748D1/de not_active Expired - Fee Related
- 2003-05-20 ES ES03755236T patent/ES2314237T3/es not_active Expired - Lifetime
- 2003-05-20 RS YU100104A patent/RS100104A/sr unknown
- 2003-05-20 WO PCT/HR2003/000025 patent/WO2003099823A2/en active IP Right Grant
- 2003-05-20 AT AT03755236T patent/ATE409191T1/de not_active IP Right Cessation
- 2003-05-20 US US10/515,711 patent/US7166583B2/en not_active Expired - Fee Related
- 2003-05-20 EP EP03755236A patent/EP1509528B1/en not_active Expired - Lifetime
- 2003-05-20 AU AU2003232372A patent/AU2003232372A1/en not_active Abandoned
- 2003-05-20 JP JP2004507480A patent/JP2005531586A/ja active Pending
- 2003-05-23 AR ARP030101804A patent/AR040040A1/es not_active Application Discontinuation
-
2004
- 2004-11-29 IS IS7568A patent/IS7568A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005531586A (ja) | 2005-10-20 |
| WO2003099823A2 (en) | 2003-12-04 |
| CN100354277C (zh) | 2007-12-12 |
| PL374504A1 (en) | 2005-10-31 |
| CN1665513A (zh) | 2005-09-07 |
| CA2487017A1 (en) | 2003-12-04 |
| HRP20020453A2 (en) | 2003-12-31 |
| US7166583B2 (en) | 2007-01-23 |
| AU2003232372A1 (en) | 2003-12-12 |
| RS100104A (en) | 2006-10-27 |
| US20050227963A1 (en) | 2005-10-13 |
| WO2003099823A3 (en) | 2004-04-29 |
| EP1509528A2 (en) | 2005-03-02 |
| EP1509528B1 (en) | 2008-09-24 |
| ES2314237T3 (es) | 2009-03-16 |
| ATE409191T1 (de) | 2008-10-15 |
| DE60323748D1 (de) | 2008-11-06 |
| IS7568A (is) | 2004-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |