RS100104A - 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof - Google Patents
1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereofInfo
- Publication number
- RS100104A RS100104A YU100104A YUP100104A RS100104A RS 100104 A RS100104 A RS 100104A YU 100104 A YU100104 A YU 100104A YU P100104 A YUP100104 A YU P100104A RS 100104 A RS100104 A RS 100104A
- Authority
- RS
- Serbia
- Prior art keywords
- diaza
- intermediates
- preparation
- necrosis factor
- tumour necrosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Predmetni pronalazak se odnosi na derivate 1,3-diaza-dibenzoazuletna, na njihove farmakološki prihvatljive soli i solvate, na procese i međuproizvode za njihovo dobijanje, kao i na njihova antiinflamatorna dejstva, a naročito na inhibiciju stvaranja faktora - α tumorske nekroze (TNF - α) i inhibiciju stvaranja interleukina - 1 (IL -1), te na njihovo analgetsko dejstvo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HR20020453A HRP20020453A2 (en) | 2002-05-23 | 2002-05-23 | 1,3-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
PCT/HR2003/000025 WO2003099823A2 (en) | 2002-05-23 | 2003-05-20 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
RS100104A true RS100104A (en) | 2006-10-27 |
Family
ID=29559974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU100104A RS100104A (en) | 2002-05-23 | 2003-05-20 | 1,3-diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
Country Status (15)
Country | Link |
---|---|
US (1) | US7166583B2 (sr) |
EP (1) | EP1509528B1 (sr) |
JP (1) | JP2005531586A (sr) |
CN (1) | CN100354277C (sr) |
AR (1) | AR040040A1 (sr) |
AT (1) | ATE409191T1 (sr) |
AU (1) | AU2003232372A1 (sr) |
CA (1) | CA2487017A1 (sr) |
DE (1) | DE60323748D1 (sr) |
ES (1) | ES2314237T3 (sr) |
HR (1) | HRP20020453A2 (sr) |
IS (1) | IS7568A (sr) |
PL (1) | PL374504A1 (sr) |
RS (1) | RS100104A (sr) |
WO (1) | WO2003099823A2 (sr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4454859B2 (ja) | 1998-11-13 | 2010-04-21 | イミュネックス・コーポレーション | ヒトtslpdnaおよびポリペプチド |
WO2003032898A2 (en) | 2001-07-23 | 2003-04-24 | Immunex Corporation | Modified human thymic stromal lymphopoietin |
HRP20020304B1 (en) * | 2002-04-10 | 2008-04-30 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-oxa-3-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the production thereof |
HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
EP1793856A2 (en) * | 2004-08-20 | 2007-06-13 | Amgen Inc. | Methods and compositions for treating allergic inflammation |
US20080096830A1 (en) * | 2005-01-13 | 2008-04-24 | Mladen Mercep | Anti-Inflammatory Macrolide Conjugates |
US20090286772A1 (en) * | 2006-02-24 | 2009-11-19 | Anh Chau | 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles |
US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3711489A (en) * | 1971-03-31 | 1973-01-16 | Pfizer | Certain 8,9-dihydro(3,4,7,8)cycloocta(1,2-d)imidazoles |
FR2211218A1 (en) * | 1972-12-21 | 1974-07-19 | Pfizer | Dibenzocyclooctaimidazoles - useful as anti inflammatories |
US4215135A (en) * | 1979-06-08 | 1980-07-29 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-1H-phenanthro[9,10-d]imidazoles |
US4198421A (en) * | 1978-11-30 | 1980-04-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 2-substituted-dibenzo[2,3:6,7]oxepino[4,5-d]imidazoles |
US4305954A (en) * | 1981-02-11 | 1981-12-15 | E. I. Du Pont De Nemours And Company | Antiinflammatory 3,4-dihydro(or 1,4-dihydro)-2-[(substituted)thio]-[1]benzopyrano[3,4-d]imidazoles and their corresponding sulfoxides and sulfones |
US5166214A (en) | 1988-12-05 | 1992-11-24 | Du Pont Merck Pharmaceutical Company | Use of imidazoles for the treatment of atherosclerosis |
CA2003283A1 (en) | 1988-12-05 | 1990-06-05 | C. Anne Higley | Imidazoles for the treatment of atherosclerosis |
EP1028954B1 (en) | 1997-04-24 | 2003-07-02 | Ortho-McNeil Pharmaceutical, Inc. | Substituted imidazoles useful in the treatment of inflammatory diseases |
HRP20000310A2 (en) | 2000-05-17 | 2002-02-28 | Pliva Farmaceutska Ind Dioniko | New dibenzoazulene compounds as tumor necrosis factor inhibitors |
-
2002
- 2002-05-23 HR HR20020453A patent/HRP20020453A2/hr not_active Application Discontinuation
-
2003
- 2003-05-20 CA CA002487017A patent/CA2487017A1/en not_active Abandoned
- 2003-05-20 CN CNB038161214A patent/CN100354277C/zh not_active Expired - Fee Related
- 2003-05-20 PL PL03374504A patent/PL374504A1/xx not_active Application Discontinuation
- 2003-05-20 DE DE60323748T patent/DE60323748D1/de not_active Expired - Fee Related
- 2003-05-20 ES ES03755236T patent/ES2314237T3/es not_active Expired - Lifetime
- 2003-05-20 RS YU100104A patent/RS100104A/sr unknown
- 2003-05-20 WO PCT/HR2003/000025 patent/WO2003099823A2/en active IP Right Grant
- 2003-05-20 AT AT03755236T patent/ATE409191T1/de not_active IP Right Cessation
- 2003-05-20 US US10/515,711 patent/US7166583B2/en not_active Expired - Fee Related
- 2003-05-20 EP EP03755236A patent/EP1509528B1/en not_active Expired - Lifetime
- 2003-05-20 AU AU2003232372A patent/AU2003232372A1/en not_active Abandoned
- 2003-05-20 JP JP2004507480A patent/JP2005531586A/ja active Pending
- 2003-05-23 AR ARP030101804A patent/AR040040A1/es not_active Application Discontinuation
-
2004
- 2004-11-29 IS IS7568A patent/IS7568A/is unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005531586A (ja) | 2005-10-20 |
WO2003099823A2 (en) | 2003-12-04 |
CN100354277C (zh) | 2007-12-12 |
PL374504A1 (en) | 2005-10-31 |
CN1665513A (zh) | 2005-09-07 |
CA2487017A1 (en) | 2003-12-04 |
HRP20020453A2 (en) | 2003-12-31 |
US7166583B2 (en) | 2007-01-23 |
AU2003232372A1 (en) | 2003-12-12 |
US20050227963A1 (en) | 2005-10-13 |
WO2003099823A3 (en) | 2004-04-29 |
EP1509528A2 (en) | 2005-03-02 |
EP1509528B1 (en) | 2008-09-24 |
ES2314237T3 (es) | 2009-03-16 |
ATE409191T1 (de) | 2008-10-15 |
DE60323748D1 (de) | 2008-11-06 |
AR040040A1 (es) | 2005-03-09 |
IS7568A (is) | 2004-11-29 |
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