BR112022001922A2 - Compostos de heteroarila de anel fundido como inibidores de ripk1 - Google Patents

Compostos de heteroarila de anel fundido como inibidores de ripk1

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Publication number
BR112022001922A2
BR112022001922A2 BR112022001922A BR112022001922A BR112022001922A2 BR 112022001922 A2 BR112022001922 A2 BR 112022001922A2 BR 112022001922 A BR112022001922 A BR 112022001922A BR 112022001922 A BR112022001922 A BR 112022001922A BR 112022001922 A2 BR112022001922 A2 BR 112022001922A2
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BR
Brazil
Prior art keywords
ripk1
inhibitors
fused
ring heteroaryl
compounds
Prior art date
Application number
BR112022001922A
Other languages
English (en)
Inventor
Cheolhwan Yoon
Cheolkyu Han
Jeongbeob Seo
Jonghwan Bae
Moonhwan Kim
Namhee Kim
Original Assignee
Bisichem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bisichem Co Ltd filed Critical Bisichem Co Ltd
Publication of BR112022001922A2 publication Critical patent/BR112022001922A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

compostos de heteroarila de anel fundido como inibidores de ripk1. a invenção fornece novos compostos heterocíclicos substituídos representados pela fórmula i, ou um sal, solvato, polimorfo, éster, tautômero ou pró-fármaco farmaceuticamente aceitável dos mesmos, e uma composição compreendendo esses compostos. os compostos fornecidos podem ser usados como inibidores de ripk1 e os métodos terapêuticos.
BR112022001922A 2019-08-09 2020-08-09 Compostos de heteroarila de anel fundido como inibidores de ripk1 BR112022001922A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962884797P 2019-08-09 2019-08-09
PCT/KR2020/010513 WO2021029632A1 (en) 2019-08-09 2020-08-09 Fused ring heteroaryl compounds as ripk1 inhibitors

Publications (1)

Publication Number Publication Date
BR112022001922A2 true BR112022001922A2 (pt) 2022-05-03

Family

ID=74498048

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022001922A BR112022001922A2 (pt) 2019-08-09 2020-08-09 Compostos de heteroarila de anel fundido como inibidores de ripk1

Country Status (10)

Country Link
US (1) US20210040115A1 (pt)
EP (1) EP4010340A4 (pt)
JP (2) JP2022544341A (pt)
KR (1) KR20220044330A (pt)
CN (1) CN114206861A (pt)
AU (1) AU2020331330B2 (pt)
BR (1) BR112022001922A2 (pt)
CA (1) CA3150465A1 (pt)
IL (1) IL290367A (pt)
WO (1) WO2021029632A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115246796A (zh) * 2021-04-27 2022-10-28 中国科学院上海有机化学研究所 一种抑制细胞程序性死亡的化合物及其制备方法
CA3231925A1 (en) * 2021-09-17 2023-03-23 Bisichem Co., Ltd. Fused heterocyclic rings as ripk1 inhibitors
CN114736197B (zh) * 2022-06-13 2022-09-13 南京医工医药技术有限公司 咪唑啉酮衍生物及其用途
CN115417772B (zh) * 2022-09-26 2024-07-19 无锡双启科技有限公司 一种3-硝基-4-氟苯甲醚的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI648274B (zh) * 2013-02-15 2019-01-21 英商葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之雜環醯胺類 （二）
AU2015304851A1 (en) * 2014-08-21 2017-02-23 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as RIP1 kinase inhibitors as medicaments
JP6974331B2 (ja) * 2016-02-05 2021-12-01 デナリ セラピューティクス インコーポレイテッドDenali Therapeutics Inc. 化合物、組成物及び方法
WO2018007973A2 (en) * 2016-07-06 2018-01-11 Glaxosmithkline Intellectual Property Development Limited Process and intermediates for preparing benzoxazepines
JP2021523226A (ja) * 2018-05-03 2021-09-02 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｒｉｐ１阻害剤化合物並びにそれを製造及び使用するための方法
CN109134448B (zh) * 2018-10-16 2020-11-27 中南大学湘雅医院 杂环化合物及其盐、制备方法、用途和药物

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Publication number Publication date
EP4010340A4 (en) 2023-08-16
JP2022544341A (ja) 2022-10-17
CA3150465A1 (en) 2021-02-18
CN114206861A (zh) 2022-03-18
KR20220044330A (ko) 2022-04-07
JP2024116109A (ja) 2024-08-27
EP4010340A1 (en) 2022-06-15
WO2021029632A1 (en) 2021-02-18
AU2020331330B2 (en) 2023-11-23
US20210040115A1 (en) 2021-02-11
IL290367A (en) 2022-04-01
AU2020331330A1 (en) 2022-02-24

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