AR036173A1 - Compuesto de bencenosulfonamida y su uso en la elaboracion de una preparacion util para el tratamiento o la prevencion de una enfermedad mediada por el alfa-2b-adrenoceptor - Google Patents
Compuesto de bencenosulfonamida y su uso en la elaboracion de una preparacion util para el tratamiento o la prevencion de una enfermedad mediada por el alfa-2b-adrenoceptorInfo
- Publication number
- AR036173A1 AR036173A1 ARP020102661A ARP020102661A AR036173A1 AR 036173 A1 AR036173 A1 AR 036173A1 AR P020102661 A ARP020102661 A AR P020102661A AR P020102661 A ARP020102661 A AR P020102661A AR 036173 A1 AR036173 A1 AR 036173A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- branched
- straight
- halogen
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de bencenosulfonamida útil para el tratamiento o prevención de una enfermedad mediada por el alfa-2B-adrenoreceptor en un mamífero, de la fórmula (1) o una sal del mismo farmacéuticamente aceptable, en donde: R1, R2, R3, R4 y R5 son independientemente entre sí H, un grupo alquilo o alcoxi recto o ramificado C1-4, o un halógeno; X es H, una cadena de alquilo C1-4 recta o ramificada, fenilo u -OH; Z es H, acetilo, -CH2Ph-O-CF3 ó -CH2-Ph-CF3, en donde Ph es fenilo; Y es una estructura de anillo opcionalmente unida a la fórmula (1) con una cadena de alquilo que tiene uno o más átomos de C, en donde la estructura de anillo es: a) fenilo opcionalmente mono- o disustituido, y cada sustituyente es seleccionado independientemente de un halógeno, una cadena de alquilo o alcoxi recta o ramificada con C1-4, grupo metilo o metoxi halógeno sustituido, un nitrilo, una amida, amino o un grupo nitro; b) 2-bencimidazolilo, 2-imidazolilo, o 2 ó 3-indolilo, en donde un N opcionalmente tiene un sustituyente que es una cadena de alquilo o alcoxi recta o ramificada con C1-4, o bencilo; y porque el 2-bencimidazolilo, 2-imidazolilo o 2- ó 3-indolilo es opcionalmente mono- o disustituido, y cada sustituyente puede ser, de manera independiente, un grupo alquilo o alcoxi recto o ramificado con C1-4, o un halógeno; c) piridinilo opcionalmente mono- o disustituido, y cada sustituyente puede ser, de manera independiente, un grupo alquilo o alcoxi recto o ramificado con C1-4, o un halógeno; o d) naftilo opcionalmente mono- o disustituido, y cada sustituyente puede ser, de manera independiente, un grupo alquilo o alcoxi recto o ramificado con C1-4, o un halógeno; excluyendo 4-[(1H-bencimidazol-2-ilmetil)-amino]-N-(4,6-dimetilpirimidin-2-il)-bencenosulfonamida, N-(4,6-dimetilpirimidin-2-il)-4-[(1-metil-1H-bencimidazol-2-ilmetil)-amino]-bencenosulfonamida, N-(4,6-dimetilpirimidin-2-il)-4-[(1-etil-1H-bencimidazol-2-ilmetil)-amino]-bencenosulfonamida, y N-(4-metil-2-pirimidinil)-4-[(1H-bencimidazol-2-ilmetil)-amino]-bencenosulfonamida. Uso del compuesto de fórmula (1) en donde X también puede ser =O, para elaborar una composición farmacéutica útil en el tratamiento de infarto de miocardio agudo (IMA), angina de pecho inestable, forma variante de angina de pecho de Prinzemetal, otras formas de angina de pecho y enfermedad cardíaca coronaria (ECC) crónica y prevención de restenosis después de angioplastía coronaria en casos en los que la vasoconstricción desempena un papel en la restenosis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30644901P | 2001-07-20 | 2001-07-20 | |
| FI20011560A FI116940B (fi) | 2001-07-20 | 2001-07-20 | Alfa-2B-adrenoseptorivälitteisen sairauden hoitoon tai ehkäisyyn käyttökelpoiset yhdisteet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036173A1 true AR036173A1 (es) | 2004-08-18 |
Family
ID=8561670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102661A AR036173A1 (es) | 2001-07-20 | 2002-07-16 | Compuesto de bencenosulfonamida y su uso en la elaboracion de una preparacion util para el tratamiento o la prevencion de una enfermedad mediada por el alfa-2b-adrenoceptor |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6767909B2 (es) |
| KR (1) | KR20040030850A (es) |
| CN (1) | CN1753877A (es) |
| AR (1) | AR036173A1 (es) |
| FI (1) | FI116940B (es) |
| PE (1) | PE20030587A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| TW200524888A (en) * | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| FI118265B (fi) * | 2004-01-15 | 2007-09-14 | Jurilab Ltd Oy | Menetelmä akuutin sydäninfarktin ja sepelvaltimotaudin riskin havaitsemiseksi |
| AU2007318922C1 (en) | 2006-11-07 | 2013-09-12 | Proteologics Ltd. | Pyrimidine derivatives as POSH and POSH-AP inhibitors |
| CA2926950C (en) | 2013-10-10 | 2022-10-11 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino) benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
| CN104189909B (zh) * | 2014-09-18 | 2017-04-12 | 中国人民解放军第三军医大学 | 肾上腺素受体拮抗剂在制备缓解脑损伤引起钠电流增加的药物中应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| US6150389A (en) | 1994-07-11 | 2000-11-21 | Allergan Sales, Inc. | Comformationally rigid bicyclic and adamantane derivatives useful as α2 -adrenergic blocking agents |
| US6521632B2 (en) | 2000-02-11 | 2003-02-18 | Oy Juvantia Pharma Ltd | Method for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor |
| EP1253926A1 (en) | 2000-02-11 | 2002-11-06 | Oy Juvantia Pharma Ltd | Compounds useful for the treatment or prevention of a disease mediated by the alpha-2b-adrenoceptor |
-
2001
- 2001-07-20 FI FI20011560A patent/FI116940B/fi not_active IP Right Cessation
-
2002
- 2002-07-16 AR ARP020102661A patent/AR036173A1/es unknown
- 2002-07-17 PE PE2002000634A patent/PE20030587A1/es not_active Application Discontinuation
- 2002-07-17 US US10/196,123 patent/US6767909B2/en not_active Expired - Fee Related
- 2002-07-22 KR KR10-2004-7001043A patent/KR20040030850A/ko not_active Application Discontinuation
- 2002-07-22 CN CNA02814595XA patent/CN1753877A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040030850A (ko) | 2004-04-09 |
| FI20011560A0 (fi) | 2001-07-20 |
| FI20011560A (fi) | 2003-01-21 |
| PE20030587A1 (es) | 2003-07-08 |
| CN1753877A (zh) | 2006-03-29 |
| US6767909B2 (en) | 2004-07-27 |
| US20030073710A1 (en) | 2003-04-17 |
| FI116940B (fi) | 2006-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR046244A1 (es) | Activadores de glucoquinasa heteroaromaticos de seis miembros 5- sustituidos | |
| NL300877I2 (nl) | obeticholzuur | |
| EA200800924A1 (ru) | Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера | |
| EA200702498A1 (ru) | N-(пиридин-2-ил)сульфонамидные производные | |
| AR035430A1 (es) | Indanil aminas aciladas, un metodo para su sintesis, composiciones farmaceuticas que las comprenden y el uso de las mismas para la fabricacion de un medicamento | |
| PE20010628A1 (es) | Compuestos de amina ciclica, su produccion y su uso | |
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| EA200200571A1 (ru) | Новая композиция и ее применение | |
| RU2009115653A (ru) | Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения | |
| FI921850A (fi) | Anvaendning av sulfonamider som laekemedel och nya sulfonamider | |
| DK2314582T3 (da) | Heterocykliske forbindelser som antivirusmidler | |
| CO5261605A1 (es) | Compustos farmaceuticos | |
| CO5251381A1 (es) | Derivados de adamantano, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
| IS2734B (is) | Pýrasólafleiður og notkun þar á, ásamt lyfjasamsetningum | |
| RU96109378A (ru) | Ингибиторы протеазы вич | |
| DK0526708T3 (da) | Sulfonamider, deres fremstilling og anvendelse som lægemiddel og mellemprodukter | |
| PE20061155A1 (es) | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas | |
| GT200600340A (es) | Inhibidores macrociclicos del virus de hepatitis c | |
| AR044650A1 (es) | Derivados de tiofeno - pirimidinona y su uso en la terapia de enfermedades que requieren la inhibicion de la enzima 17b-hidroxiesteroide-dehidrogenasa. | |
| AR030053A1 (es) | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas | |
| AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| AR054129A1 (es) | Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7 | |
| EA200700901A1 (ru) | Производные 2-амидо-4-фенилтиазола, их получение и применение в терапии | |
| AR039689A1 (es) | Difenilazetidinonas sustituidas, medicamentos que comprenden estos compuestos y su uso | |
| PE20081383A1 (es) | Inhibidores benzoimidazolicos de trpv1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |