AR034342A1 - Metodo de determinacion de un regimen quimioterapeutico basado en la expresion de glutationa-s-transferasa pi - Google Patents

Metodo de determinacion de un regimen quimioterapeutico basado en la expresion de glutationa-s-transferasa pi

Info

Publication number
AR034342A1
AR034342A1 ARP020101954A ARP020101954A AR034342A1 AR 034342 A1 AR034342 A1 AR 034342A1 AR P020101954 A ARP020101954 A AR P020101954A AR P020101954 A ARP020101954 A AR P020101954A AR 034342 A1 AR034342 A1 AR 034342A1
Authority
AR
Argentina
Prior art keywords
gst
expression
glutationa
transferasa
determination
Prior art date
Application number
ARP020101954A
Other languages
English (en)
Original Assignee
Response Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Response Genetics Inc filed Critical Response Genetics Inc
Publication of AR034342A1 publication Critical patent/AR034342A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01018—Glutathione transferase (2.5.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente se relaciona con métodos de pronóstico que son útiles en medicina, en particular, en la quimioterapia contra el cáncer. El objetivo de la presente es proporcionar un método para la evaluación de los niveles de expresión de GST-pi en tejidos fijados o fijados y empotrados en parafina, y pronosticar la probable resistencia o sensibilidad del tumor de un paciente al tratamiento con terapias a base de platino, por examen de la cantidad de ARNm de GST-pi en las células tumorales de un paciente, y comparándola con un nivel de expresión de umbral predeterminado. Más específicamente, la presente proporciona el par de cebadores de oligonucleótidos GST-pi y métodos que comprenden su uso para la detección de los niveles de ARNm de GST-pi.
ARP020101954A 2001-06-14 2002-05-24 Metodo de determinacion de un regimen quimioterapeutico basado en la expresion de glutationa-s-transferasa pi AR034342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/879,986 US6686155B2 (en) 2001-06-14 2001-06-14 Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression

Publications (1)

Publication Number Publication Date
AR034342A1 true AR034342A1 (es) 2004-02-18

Family

ID=25375288

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101954A AR034342A1 (es) 2001-06-14 2002-05-24 Metodo de determinacion de un regimen quimioterapeutico basado en la expresion de glutationa-s-transferasa pi

Country Status (15)

Country Link
US (4) US6686155B2 (es)
EP (1) EP1407047B1 (es)
JP (2) JP4303104B2 (es)
KR (2) KR20090060380A (es)
CN (2) CN100494398C (es)
AR (1) AR034342A1 (es)
AU (1) AU2002305573B2 (es)
CA (1) CA2450257C (es)
ES (1) ES2457077T3 (es)
HK (1) HK1070921A1 (es)
IL (2) IL159301A0 (es)
MX (1) MXPA03011632A (es)
NZ (1) NZ530520A (es)
TW (1) TWI338049B (es)
WO (1) WO2002103055A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
WO2005100606A2 (en) * 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
US20060115827A1 (en) * 2004-07-01 2006-06-01 University Of Southern California Genetic markers for predicting disease and treatment outcome
WO2006119464A1 (en) * 2005-05-04 2006-11-09 University Of South Florida Predicting treatment response in cancer subjects
US20070059753A1 (en) * 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
ES2401475T3 (es) * 2007-06-15 2013-04-19 University Of South Florida Métodos de diagnóstico y tratamiento del cáncer
AU2009339802B2 (en) * 2009-02-16 2014-07-24 Atlas Antibodies Ab RBM3 as a marker for malignant melanoma prognosis
JP5361488B2 (ja) * 2009-03-24 2013-12-04 オリンパス株式会社 蛍光観察装置
JP5680442B2 (ja) * 2011-02-24 2015-03-04 シスメックス株式会社 癌細胞のタキサン系抗癌剤感受性判定方法、それを実現するためのコンピュータプログラム及び装置
GB201316027D0 (en) * 2013-09-09 2013-10-23 Almac Diagnostics Ltd Molecular diagnostic test for oesophageal cancer
CN113577290B (zh) * 2014-12-26 2023-10-24 日东电工株式会社 细胞死亡诱导试剂、细胞增殖抑制试剂及用于治疗由细胞增殖异常导致的疾病的医药组合物
CN112321489B (zh) * 2020-10-15 2022-04-19 中山大学 一种基于活性巯基和报告离子的亲电分子探针及其制备方法和应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830969A (en) * 1981-08-31 1989-05-16 The Research Foundation Of State University Of New York Process for the rapid and simple isolation of nucleic acids
US4843155A (en) * 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5128247A (en) * 1989-08-14 1992-07-07 Board Of Regents, The University Of Texas System Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources
US5942389A (en) * 1990-10-19 1999-08-24 Board Of Trustees Of The University Of Illinois Genes and genetic elements associated with sensitivity to cisplatin
US5204241A (en) * 1990-10-22 1993-04-20 Oxi-Gene Inc. Glutathione-S-transferase mu as a measure of drug resistance
US5620852A (en) * 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
US5284940A (en) * 1990-11-14 1994-02-08 Hri Research, Inc. Preparation for nucleic acid samples
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
US5502166A (en) * 1992-02-26 1996-03-26 Mitsubishi Chemical Corporation NMDH receptor proteins and genes encoding the same
JP3615545B2 (ja) * 1993-02-01 2005-02-02 キアゲン・エヌ・ブイ 第四級アンモニウム塩界面活性剤及びそのｒｎａの単離剤
US5637687A (en) * 1993-08-31 1997-06-10 Wiggins; James C. Methods and compositions for isolating nucleic acids
AU2289495A (en) 1994-04-13 1995-11-10 Uab Research Foundation, The Dihydropyrimidine dehydrogenase compositions and methods of use
US5643767A (en) * 1994-05-02 1997-07-01 The Rockefeller University Process for isolating cellular components
CA2153215A1 (en) * 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
US6136605A (en) * 1994-08-26 2000-10-24 Wisconsin Alumni Research Foundation Glutathione S-transferase isoforms
US5707802A (en) * 1995-01-13 1998-01-13 Ciba Corning Diagnostics Corp. Nucleic acid probes for the detection and identification of fungi
US5777099A (en) * 1995-02-24 1998-07-07 Biotecx Laboratories, Inc. RNA separation
US5945515A (en) * 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
DE29601618U1 (de) * 1996-01-31 1996-07-04 InViTek GmbH, 13125 Berlin Vorrichtung zur gleichzeitigen multiplen Isolierung
EP0791654A1 (en) * 1996-02-21 1997-08-27 Jürgen A. Dr. Richt Polypeptides corresponding to the amino acid sequences of proteins p57 or p9.5 of Borna disease virus, nucleic acid fragments coding therefore and their use for diagnostic and immunization purposes
KR0177890B1 (ko) * 1996-03-05 1999-04-01 이병언 반응특이성이 향상된 중합효소 연쇄반응용 튜브
ES2185002T3 (es) 1996-03-20 2003-04-16 Us Gov Health & Human Serv Metodos y composiciones para detectar mutaciones por empalme de la deshidrogenasa de dihidro-pirimidina.
EP0912726A4 (en) * 1996-05-10 2001-07-18 Phylomed Corp METHODS FOR OXIDIZING BISULFIDE LINKS WITH OZONE
US5968737A (en) * 1996-11-12 1999-10-19 The University Of Mississippi Method of identifying inhibitors of glutathione S-transferase (GST) gene expression
AU6764398A (en) 1997-03-20 1998-10-12 Variagenics, Inc. Target genes for allele-specific drugs
US6248535B1 (en) 1999-12-20 2001-06-19 University Of Southern California Method for isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
WO2002044423A2 (en) * 2000-12-01 2002-06-06 Response Genetics, Inc. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
US7618793B2 (en) * 2004-10-20 2009-11-17 The Regents Of The University Of Washington Identifying agents for decreasing cellular toxicity associated with huntingin polypeptide
US7618777B2 (en) * 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
US7615729B2 (en) * 2007-12-10 2009-11-10 Aptina Imaging Corporation Apparatus and method for resonant lens focusing

Also Published As

Publication number Publication date
IL159301A0 (en) 2004-06-01
ES2457077T3 (es) 2014-04-24
MXPA03011632A (es) 2005-04-19
KR20090060380A (ko) 2009-06-11
JP4303104B2 (ja) 2009-07-29
CN1541277A (zh) 2004-10-27
US20020197609A1 (en) 2002-12-26
CN1763064A (zh) 2006-04-26
CA2450257A1 (en) 2002-12-27
HK1070921A1 (en) 2005-06-30
EP1407047A4 (en) 2005-03-30
CN100494398C (zh) 2009-06-03
AU2002305573B2 (en) 2009-01-08
CN100355770C (zh) 2007-12-19
JP4308309B2 (ja) 2009-08-05
EP1407047A1 (en) 2004-04-14
US6686155B2 (en) 2004-02-03
US20040241705A1 (en) 2004-12-02
EP1407047B1 (en) 2014-01-22
TWI338049B (en) 2011-03-01
KR100918927B1 (ko) 2009-09-28
US20050019783A1 (en) 2005-01-27
US20050074775A1 (en) 2005-04-07
KR20040018269A (ko) 2004-03-02
NZ530520A (en) 2006-10-27
JP2004530434A (ja) 2004-10-07
CA2450257C (en) 2012-11-06
WO2002103055A1 (en) 2002-12-27
IL159301A (en) 2010-06-16
JP2009000118A (ja) 2009-01-08
US7138507B2 (en) 2006-11-21

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