AR034278A1 - Compuestos de 4-amino-azepan-3-ona 1-amino-1-acil cicloalcano c3-6 sustituidos, composiciones farmaceuticas que los comprenden, intermediarios, procedimiento para la sintesis de dichos compuestos, y el uso de dichos compuestos en la fabricacion de medicamentos - Google Patents
Compuestos de 4-amino-azepan-3-ona 1-amino-1-acil cicloalcano c3-6 sustituidos, composiciones farmaceuticas que los comprenden, intermediarios, procedimiento para la sintesis de dichos compuestos, y el uso de dichos compuestos en la fabricacion de medicamentosInfo
- Publication number
- AR034278A1 AR034278A1 ARP010105409A ARP010105409A AR034278A1 AR 034278 A1 AR034278 A1 AR 034278A1 AR P010105409 A ARP010105409 A AR P010105409A AR P010105409 A ARP010105409 A AR P010105409A AR 034278 A1 AR034278 A1 AR 034278A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- compounds
- cycloalkyl
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102200160920 rs35304565 Human genes 0.000 abstract 2
- QTLLOLTVQMFWDZ-UHFFFAOYSA-N 4-aminoazepan-3-one Chemical class NC1CCCNCC1=O QTLLOLTVQMFWDZ-UHFFFAOYSA-N 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 208000024693 gingival disease Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25250800P | 2000-11-22 | 2000-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034278A1 true AR034278A1 (es) | 2004-02-18 |
Family
ID=22956303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105409A AR034278A1 (es) | 2000-11-22 | 2001-11-20 | Compuestos de 4-amino-azepan-3-ona 1-amino-1-acil cicloalcano c3-6 sustituidos, composiciones farmaceuticas que los comprenden, intermediarios, procedimiento para la sintesis de dichos compuestos, y el uso de dichos compuestos en la fabricacion de medicamentos |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1392657A4 (cs) |
| JP (1) | JP2005513083A (cs) |
| KR (1) | KR20040004445A (cs) |
| CN (1) | CN1635903A (cs) |
| AR (1) | AR034278A1 (cs) |
| AU (1) | AU2001298052A1 (cs) |
| BR (1) | BR0115473A (cs) |
| CA (1) | CA2436850A1 (cs) |
| CZ (1) | CZ20031403A3 (cs) |
| HU (1) | HUP0301964A3 (cs) |
| IL (1) | IL155997A0 (cs) |
| MX (1) | MXPA03004542A (cs) |
| NO (1) | NO20032328L (cs) |
| PL (1) | PL366232A1 (cs) |
| UY (1) | UY27032A1 (cs) |
| WO (1) | WO2003053331A2 (cs) |
| ZA (1) | ZA200303848B (cs) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
| AU2001243441B2 (en) | 2000-03-21 | 2004-11-25 | Smithkline Beecham Corporation | Protease inhibitors |
| NZ522965A (en) * | 2000-06-14 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
| WO2008149971A1 (ja) | 2007-06-08 | 2008-12-11 | Kyoto University | 脳動脈瘤の治療または予防薬 |
| US20100331545A1 (en) | 2007-10-24 | 2010-12-30 | Nippon Chemiphar Co., Ltd. | Regulator for signaling toll-like receptor, which comprises cathepsin inhibitor as active ingredient |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100630986B1 (ko) * | 1998-12-23 | 2006-10-09 | 스미스클라인 비참 코포레이션 | 프로테아제 억제제 |
| AU2001243441B2 (en) * | 2000-03-21 | 2004-11-25 | Smithkline Beecham Corporation | Protease inhibitors |
| NZ522965A (en) * | 2000-06-14 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
-
2001
- 2001-11-19 CN CNA018220533A patent/CN1635903A/zh active Pending
- 2001-11-19 IL IL15599701A patent/IL155997A0/xx unknown
- 2001-11-19 PL PL01366232A patent/PL366232A1/xx not_active Application Discontinuation
- 2001-11-19 KR KR10-2003-7006807A patent/KR20040004445A/ko not_active Withdrawn
- 2001-11-19 WO PCT/US2001/051647 patent/WO2003053331A2/en not_active Ceased
- 2001-11-19 BR BR0115473-7A patent/BR0115473A/pt not_active Application Discontinuation
- 2001-11-19 MX MXPA03004542A patent/MXPA03004542A/es unknown
- 2001-11-19 CA CA002436850A patent/CA2436850A1/en not_active Abandoned
- 2001-11-19 CZ CZ20031403A patent/CZ20031403A3/cs unknown
- 2001-11-19 AU AU2001298052A patent/AU2001298052A1/en not_active Abandoned
- 2001-11-19 JP JP2003554091A patent/JP2005513083A/ja not_active Withdrawn
- 2001-11-19 EP EP01275089A patent/EP1392657A4/en not_active Withdrawn
- 2001-11-19 HU HU0301964A patent/HUP0301964A3/hu unknown
- 2001-11-20 AR ARP010105409A patent/AR034278A1/es unknown
- 2001-11-21 UY UY27032A patent/UY27032A1/es not_active Application Discontinuation
-
2003
- 2003-05-16 ZA ZA200303848A patent/ZA200303848B/en unknown
- 2003-05-22 NO NO20032328A patent/NO20032328L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20031403A3 (cs) | 2003-10-15 |
| UY27032A1 (es) | 2002-07-31 |
| NO20032328D0 (no) | 2003-05-22 |
| KR20040004445A (ko) | 2004-01-13 |
| PL366232A1 (en) | 2005-01-24 |
| WO2003053331A3 (en) | 2003-11-13 |
| HUP0301964A3 (en) | 2007-09-28 |
| ZA200303848B (en) | 2004-06-28 |
| IL155997A0 (en) | 2003-12-23 |
| BR0115473A (pt) | 2004-09-28 |
| EP1392657A2 (en) | 2004-03-03 |
| NO20032328L (no) | 2003-07-02 |
| JP2005513083A (ja) | 2005-05-12 |
| WO2003053331A2 (en) | 2003-07-03 |
| MXPA03004542A (es) | 2003-09-10 |
| CA2436850A1 (en) | 2003-07-03 |
| AU2001298052A1 (en) | 2003-07-09 |
| HUP0301964A2 (en) | 2007-02-28 |
| EP1392657A4 (en) | 2004-03-10 |
| CN1635903A (zh) | 2005-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR032877A1 (es) | Inhibidores alquil c(1-6)-4-amino-azepan-3-onicos de proteasas, composiciones farmaceuticas que los comprenden, intermediarios utiles en la preparacion de tales compuestos, procedimiento para la sintesis de dichos inhibidores, y uso de dichos inhibidores en la fabricacion de medicamentos | |
| AR024060A1 (es) | Nuevos compuestos farmaceuticamente activos | |
| ES2195034T3 (es) | Inhibidor de metaloproteinasas, composicion farmaceutica que contiene este inhibidor y su utilizacion farmaceutica, y procedimientos que sirven para su preparacion. | |
| ATE454382T1 (de) | Verbindungen mit selektiverinhibierender wirkung für gsk3 | |
| CY1108894T1 (el) | Νεα παραγωγα βενζιμιδαζολης | |
| UY24660A1 (es) | Procedimiento para preparar inhibidores de cisteina proteasas | |
| ES2181153T3 (es) | Compuestos de triazinilaminoestilbeno. | |
| ECSP034732A (es) | Derivado de fenetanolamina para el tratamiento de enfermedades respiratorias | |
| AR034268A1 (es) | Compuestos derivados de piperidina, su uso en preparacion de medicamentos, composicion farmaceutica, metodo de tratamiento y proceso para su preparacion | |
| CO4700421A1 (es) | Compuestos de naftilo, intermedios, composiciones y procedimientos | |
| UY27446A1 (es) | Nuevos compuestos | |
| DZ2977A1 (fr) | 4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant. | |
| UY27700A1 (es) | Compuestos oxo - azabiclícos. | |
| SE0403171D0 (sv) | New compounds | |
| NO970349L (no) | Forbindelser som er anvendbare som antiproliferative midler og GARFT inhibitorer | |
| AR018139A1 (es) | Un compuesto n-[3-hidroxi-5[(1,4,5,6-tetrahidro-5-hidroxi-2-pirimidinil)amino]benzoil]glici-3-(3-halo-5-halo-2-hidroxifenil)-beta alanina, composicionfarmaceutica y uso del mismo en la fabricacion de un medicamento. | |
| UY25143A1 (es) | Procedimiento para la preparacion de inhibidores de proteasas. | |
| AR038818A1 (es) | Compuesto de piperidina, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion | |
| ES2123652T3 (es) | 7-(2-aminoetil)-benzotiazolonas. | |
| PA8575001A1 (es) | Fluorobenzamidas como inhibidores de maob | |
| AR039651A1 (es) | Derivados de isoquinolina | |
| CO5550439A2 (es) | Compuestos derivados de arilsulfonil-piperazina que tienen afinidad al receptor 5-ht6 y composiciones farmaceuticas que los contienen | |
| AR013462A1 (es) | Nuevos peptidomimeticos para el tratamiento de trastornos oseos, metodos para su produccion y drogas que contienen estos compuestos | |
| AR008621A1 (es) | Un compuesto derivado de amina succinica, un procedimiento para llevar a cabo su preparacion y una composicion farmaceutica que comprende dichocompuesto | |
| AR032622A1 (es) | Compuestos de 4-amino-azepan-3-ona, composiciones farmaceuticas que los comprenden, intermediarios utiles en la sintesis de tales compuestos, procedimiento para la sintesis de dichos compuestos, y uso de tales compuestos en la fabricacion de medicamentos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |