AR029916A1 - N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas - Google Patents
N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianasInfo
- Publication number
- AR029916A1 AR029916A1 ARP010102092A ARP010102092A AR029916A1 AR 029916 A1 AR029916 A1 AR 029916A1 AR P010102092 A ARP010102092 A AR P010102092A AR P010102092 A ARP010102092 A AR P010102092A AR 029916 A1 AR029916 A1 AR 029916A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbons
- optionally substituted
- methods
- bacterial infections
- ariloxi
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- -1 hydroxy, amino Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 239000000081 peptide deformylase inhibitor Substances 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
- C07C239/08—Hydroxylamino compounds or their ethers or esters
- C07C239/14—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20194300P | 2000-05-05 | 2000-05-05 | |
| US23808400P | 2000-10-04 | 2000-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029916A1 true AR029916A1 (es) | 2003-07-23 |
Family
ID=26897227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102092A AR029916A1 (es) | 2000-05-05 | 2001-05-03 | N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6806369B2 (enExample) |
| EP (1) | EP1283711B1 (enExample) |
| JP (1) | JP2003532677A (enExample) |
| KR (1) | KR20020093127A (enExample) |
| CN (1) | CN1427721A (enExample) |
| AR (1) | AR029916A1 (enExample) |
| AT (1) | ATE389403T1 (enExample) |
| AU (1) | AU2001261218A1 (enExample) |
| BR (1) | BR0110206A (enExample) |
| CA (1) | CA2408236A1 (enExample) |
| CZ (1) | CZ20023618A3 (enExample) |
| DE (1) | DE60133273T2 (enExample) |
| ES (1) | ES2300330T3 (enExample) |
| HU (1) | HUP0302505A2 (enExample) |
| IL (1) | IL152638A0 (enExample) |
| MX (1) | MXPA02010843A (enExample) |
| NO (1) | NO20025281L (enExample) |
| NZ (1) | NZ521560A (enExample) |
| PL (1) | PL359865A1 (enExample) |
| WO (1) | WO2001085170A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1383736B1 (en) * | 2001-04-05 | 2009-06-17 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| US6852882B2 (en) * | 2001-06-05 | 2005-02-08 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| WO2004052919A2 (en) * | 2002-12-11 | 2004-06-24 | Smithkline Beecham Corporation | Peptide deformylase inhibitors |
| EP1683521A1 (en) * | 2005-01-21 | 2006-07-26 | Centre National De La Recherche Scientifique (Cnrs) | Peptide deformylase inhibitors, their use, and pharmaceutical compositions containing the same |
| DE102005019181A1 (de) | 2005-04-25 | 2006-10-26 | Novartis Ag | Peptid-Deformylase (PDF) Inhibitoren 1 |
| CN101166740B (zh) * | 2005-04-25 | 2010-12-29 | 诺瓦提斯公司 | 用作肽脱甲酰基酶(pdf)抑制剂的咪唑并[1,2-a]吡啶衍生物 |
| WO2006131303A2 (en) * | 2005-06-07 | 2006-12-14 | Novartis Ag | Peptide deformylase (pdf) inhibitors 4 |
| WO2007040289A1 (en) * | 2005-10-05 | 2007-04-12 | Promeditech Inc. | Deformylase inhibitor, process for the preparation thereof, and composition comprising the same |
| KR100753796B1 (ko) * | 2006-07-28 | 2007-08-31 | 주식회사 프로메디텍 | 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3282986A (en) | 1960-10-06 | 1966-11-01 | Merck & Co Inc | N-acylated hydroxamic acids and derivatives thereof |
| EP0196184B1 (en) | 1985-03-16 | 1992-09-16 | The Wellcome Foundation Limited | Aryl derivatives |
| GB8531838D0 (en) * | 1985-12-30 | 1986-02-05 | Wellcome Found | Aryl derivatives |
| PL154186B1 (en) * | 1987-07-15 | 1991-07-31 | Wellcome Found | Method for manufacturing arylic derivatives of the hydroxamic acid |
| DK1001930T3 (da) | 1997-07-31 | 2003-03-24 | Abbott Lab | N-hydroxyformamidderivater som inhibitorer af matrix-metalloproteinaser |
| US6235786B1 (en) * | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6294573B1 (en) * | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| EP1052984B1 (en) * | 1998-02-07 | 2004-05-12 | Vernalis (Oxford) Ltd | Antibacterial agents |
| AR028075A1 (es) * | 2000-05-05 | 2003-04-23 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| US20040034024A1 (en) | 2001-05-04 | 2004-02-19 | Aubart Kelly M | Peptide deformylase inhibitors |
-
2001
- 2001-05-03 AR ARP010102092A patent/AR029916A1/es not_active Application Discontinuation
- 2001-05-04 EP EP01935094A patent/EP1283711B1/en not_active Expired - Lifetime
- 2001-05-04 CZ CZ20023618A patent/CZ20023618A3/cs unknown
- 2001-05-04 BR BR0110206-0A patent/BR0110206A/pt not_active Application Discontinuation
- 2001-05-04 MX MXPA02010843A patent/MXPA02010843A/es unknown
- 2001-05-04 PL PL35986501A patent/PL359865A1/xx unknown
- 2001-05-04 DE DE60133273T patent/DE60133273T2/de not_active Expired - Lifetime
- 2001-05-04 CN CN01808997A patent/CN1427721A/zh active Pending
- 2001-05-04 HU HU0302505A patent/HUP0302505A2/hu unknown
- 2001-05-04 WO PCT/US2001/014593 patent/WO2001085170A1/en not_active Ceased
- 2001-05-04 US US10/275,522 patent/US6806369B2/en not_active Expired - Fee Related
- 2001-05-04 CA CA002408236A patent/CA2408236A1/en not_active Abandoned
- 2001-05-04 JP JP2001581824A patent/JP2003532677A/ja active Pending
- 2001-05-04 NZ NZ521560A patent/NZ521560A/en unknown
- 2001-05-04 AU AU2001261218A patent/AU2001261218A1/en not_active Abandoned
- 2001-05-04 ES ES01935094T patent/ES2300330T3/es not_active Expired - Lifetime
- 2001-05-04 KR KR1020027014802A patent/KR20020093127A/ko not_active Withdrawn
- 2001-05-04 IL IL15263801A patent/IL152638A0/xx unknown
- 2001-05-04 AT AT01935094T patent/ATE389403T1/de not_active IP Right Cessation
-
2002
- 2002-11-04 NO NO20025281A patent/NO20025281L/no not_active Application Discontinuation
-
2004
- 2004-04-05 US US10/818,074 patent/US7115605B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR0110206A (pt) | 2003-01-28 |
| ES2300330T3 (es) | 2008-06-16 |
| WO2001085170A1 (en) | 2001-11-15 |
| US20040192719A1 (en) | 2004-09-30 |
| NO20025281D0 (no) | 2002-11-04 |
| ATE389403T1 (de) | 2008-04-15 |
| CZ20023618A3 (cs) | 2003-09-17 |
| EP1283711B1 (en) | 2008-03-19 |
| CN1427721A (zh) | 2003-07-02 |
| DE60133273T2 (de) | 2009-03-05 |
| WO2001085170A9 (en) | 2006-01-26 |
| NZ521560A (en) | 2004-05-28 |
| DE60133273D1 (de) | 2008-04-30 |
| AU2001261218A1 (en) | 2001-11-20 |
| US20040053932A1 (en) | 2004-03-18 |
| HUP0302505A2 (hu) | 2003-12-29 |
| KR20020093127A (ko) | 2002-12-12 |
| US6806369B2 (en) | 2004-10-19 |
| PL359865A1 (en) | 2004-09-06 |
| IL152638A0 (en) | 2003-06-24 |
| CA2408236A1 (en) | 2001-11-15 |
| EP1283711A4 (en) | 2003-05-21 |
| MXPA02010843A (es) | 2003-03-27 |
| US7115605B2 (en) | 2006-10-03 |
| JP2003532677A (ja) | 2003-11-05 |
| EP1283711A1 (en) | 2003-02-19 |
| NO20025281L (no) | 2003-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |