AR027352A1 - Nuevos moduladores alostericos positivos de receptores de ampa (paarm), procedimientos para su preparacion y su utilizacion como medicamentos - Google Patents
Nuevos moduladores alostericos positivos de receptores de ampa (paarm), procedimientos para su preparacion y su utilizacion como medicamentosInfo
- Publication number
- AR027352A1 AR027352A1 ARP010100494A ARP010100494A AR027352A1 AR 027352 A1 AR027352 A1 AR 027352A1 AR P010100494 A ARP010100494 A AR P010100494A AR P010100494 A ARP010100494 A AR P010100494A AR 027352 A1 AR027352 A1 AR 027352A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- well
- so2h
- nr7r8
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Suspension/Interruption
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se refiere a nuevos moduladores alostéricos positivos de receptores de AMPA de la formula general (1) en la que: A significa un átomo de azufre, un átomode oxígeno, NH o N-alquilo C1-4; R1 significa un radical seleccionado entre el grupo que consta d e hidrogeno, de un grupo alquilo C1-6 eventualmente sustituidocon uno o varios átomos de halogeno, así como de -SO2H, -SO2-alquilo C1-6, -SO-alquilo C1-6, -CO-alquilo C1-6, -O, fenil-alquilo C1-4, alquil C1-4-NR7R8 yalquil C1-4-O-alquilo C1-4, o de c icloalquilo C3-6; R2, R9 iguales o diferentes, significan un radical seleccionado entre el grupo que consta de hidrogeno, deun grupo alquilo C1-6 eventualmente sustituido con uno o varios átomos de halogeno, así como de halogeno, -NO2, -SO2H, -SO2-al quilo C1-6, -SO-alquilo C1-6,-CO-alquilo C1-6, -OH, -O-alquilo C1-6, -S-alquilo C1-6, alquil C1-4-NR7R8 y alquil C1-4-O-alquilo C1-6, o de cicloalquilo C3-6; o R1 y R2 significan en comunun puente de alquileno C2-6; R7, R8 iguales o diferentes, signi fican hidrogeno o alquilo C1-4; y R3, R4, R5, R6 iguales o diferentes, significan un radicalseleccionado entre el grupo que consta de hidrogeno, de un grupo alquilo C1-6 eventualmente sustituido con uno o varios átomos de halogeno, así como de fenil- alquilo C1-4, halogeno, -CN, -NO2, -SO2H, SO3H, -SO2-alquilo C1-6, -SO-alquilo C1-6, -SO2-NR7R8, -COOH, -CO-alquilo C1-6, -O-CO-alquilo C1-4, -CO-O-alquiloC1-4, -CO-NR7R8-alquilo C1-4, -OH, -O-alquilo C1-6, -S-alquilo C1-6, -NR7R8 y un radical arilo eventualmente sustituido una vez o multiples veces con átomos dehalogeno, -NO2, -SO2H o alquilo C1-4, eventualmente en forma de sus diferentes enantiomeros y diastereoisomeros, así como de sus sales farmacologicamenteinocuas. A procedimientos para su preparacion así como a su utilizacion como medicamentos. Utiles en enfermedades de demencia, neurodegenerativas o psicoticas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10004572A DE10004572A1 (de) | 2000-02-02 | 2000-02-02 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR027352A1 true AR027352A1 (es) | 2003-03-26 |
Family
ID=7629599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010100494A Suspension/Interruption AR027352A1 (es) | 2000-02-02 | 2001-02-02 | Nuevos moduladores alostericos positivos de receptores de ampa (paarm), procedimientos para su preparacion y su utilizacion como medicamentos |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6525045B2 (es) |
| EP (1) | EP1265904B1 (es) |
| JP (1) | JP4891510B2 (es) |
| AR (1) | AR027352A1 (es) |
| AT (1) | ATE277054T1 (es) |
| AU (1) | AU2001240561A1 (es) |
| CA (1) | CA2399377C (es) |
| CO (1) | CO5261505A1 (es) |
| DE (2) | DE10004572A1 (es) |
| DK (1) | DK1265904T3 (es) |
| ES (1) | ES2228817T3 (es) |
| MX (1) | MXPA02007460A (es) |
| PT (1) | PT1265904E (es) |
| TR (1) | TR200402650T4 (es) |
| UY (1) | UY26566A1 (es) |
| WO (1) | WO2001057045A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| NZ520588A (en) * | 2000-03-21 | 2004-06-25 | Smithkline Beecham Corp | Protease inhibitors |
| KR100982753B1 (ko) * | 2001-04-05 | 2010-09-16 | 콜라제넥스 파마슈티칼스, 인크 | 테트라사이클린 화합물 및 테트라사이클린 유도체의 전달조절 |
| US20030100552A1 (en) | 2001-05-17 | 2003-05-29 | Boehringer Ingelheim Pharma Kg | Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions |
| DE10123952A1 (de) * | 2001-05-17 | 2002-11-21 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| CA2458388A1 (en) * | 2001-10-10 | 2003-04-17 | Neurosearch A/S | Novel benzothiazine derivatives, their preparation and use |
| US7815391B2 (en) * | 2004-07-23 | 2010-10-19 | Kauppila Richard W | Structural member joints |
| US20060063707A1 (en) * | 2004-09-17 | 2006-03-23 | Lifelike Biomatic, Inc. | Compositions for enhancing memory and methods therefor |
| AU2009243730B2 (en) * | 2008-05-05 | 2013-07-18 | Polypeptide Laboratories Holding (Ppl) Ab | Indolesulfonyl protecting groups for protection of guanidino and amino groups |
| US20110218190A1 (en) * | 2008-11-10 | 2011-09-08 | The Regents Of The University Of California | Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction |
| BR112015031249A2 (pt) | 2013-06-13 | 2017-07-25 | Veroscience Llc | método de tratamento, método para tratar um distúrbio metabólico ou um elemento chave do mesmo, método para normalizar um ritmo diário de liberação de dopamina no sumn, método para estimular a liberação de dopamina de neurônios dopaminérgicos no sumn de um indivíduo e composição farmacêutica |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8724566D0 (en) * | 1987-10-20 | 1987-11-25 | Roussel Lab Ltd | Chemical compounds |
| US4994452A (en) * | 1989-11-28 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Inc. | Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds |
| AU3957093A (en) * | 1992-04-15 | 1993-11-18 | Rhone-Poulenc Rorer S.A. | 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide-3-carboxyl ic acid derivatives, preparation thereof and drugs containing same |
| ES2149989T3 (es) * | 1994-05-24 | 2000-11-16 | Hoffmann La Roche | Derivados triciclicos de dicarbonilo. |
| US5891871A (en) * | 1996-03-21 | 1999-04-06 | Cocensys, Inc. | Substituted 2,3-benzodiazepin-4-ones and the use thereof |
| WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| US5968928A (en) * | 1996-09-19 | 1999-10-19 | Warner-Lambert Company | Excitatory amino acid antagonists: fused-azacyclic quinoxalinediones and immunoassays thereof |
| US5969138A (en) * | 1996-11-01 | 1999-10-19 | Mitsui Chemicals, Inc. | Pyrrolidinone derivatives |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| ZA991301B (en) * | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| US6096744A (en) * | 1998-05-04 | 2000-08-01 | Warner-Lambert Company | Sulfonamide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2000
- 2000-02-02 DE DE10004572A patent/DE10004572A1/de not_active Withdrawn
-
2001
- 2001-01-30 CA CA002399377A patent/CA2399377C/en not_active Expired - Fee Related
- 2001-01-30 JP JP2001557876A patent/JP4891510B2/ja not_active Expired - Fee Related
- 2001-01-30 AT AT01911553T patent/ATE277054T1/de active
- 2001-01-30 MX MXPA02007460A patent/MXPA02007460A/es active IP Right Grant
- 2001-01-30 DE DE50103760T patent/DE50103760D1/de not_active Expired - Lifetime
- 2001-01-30 WO PCT/EP2001/000960 patent/WO2001057045A1/de active IP Right Grant
- 2001-01-30 AU AU2001240561A patent/AU2001240561A1/en not_active Abandoned
- 2001-01-30 UY UY26566A patent/UY26566A1/es not_active Application Discontinuation
- 2001-01-30 PT PT01911553T patent/PT1265904E/pt unknown
- 2001-01-30 TR TR2004/02650T patent/TR200402650T4/xx unknown
- 2001-01-30 EP EP01911553A patent/EP1265904B1/de not_active Expired - Lifetime
- 2001-01-30 ES ES01911553T patent/ES2228817T3/es not_active Expired - Lifetime
- 2001-01-30 DK DK01911553T patent/DK1265904T3/da active
- 2001-01-31 US US09/774,864 patent/US6525045B2/en not_active Expired - Lifetime
- 2001-01-31 CO CO01007094A patent/CO5261505A1/es not_active Application Discontinuation
- 2001-02-02 AR ARP010100494A patent/AR027352A1/es not_active Suspension/Interruption
-
2003
- 2003-01-06 US US10/336,865 patent/US6800623B2/en not_active Expired - Lifetime
- 2003-01-06 US US10/336,876 patent/US20030158181A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2399377C (en) | 2008-12-16 |
| MXPA02007460A (es) | 2003-01-28 |
| US20030158181A1 (en) | 2003-08-21 |
| US20030158183A1 (en) | 2003-08-21 |
| TR200402650T4 (tr) | 2004-11-22 |
| ES2228817T3 (es) | 2005-04-16 |
| US6800623B2 (en) | 2004-10-05 |
| PT1265904E (pt) | 2004-11-30 |
| DE10004572A1 (de) | 2001-08-09 |
| JP2003522180A (ja) | 2003-07-22 |
| DE50103760D1 (de) | 2004-10-28 |
| UY26566A1 (es) | 2001-08-27 |
| WO2001057045A1 (de) | 2001-08-09 |
| EP1265904A1 (de) | 2002-12-18 |
| EP1265904B1 (de) | 2004-09-22 |
| CO5261505A1 (es) | 2003-03-31 |
| DK1265904T3 (da) | 2004-10-25 |
| ATE277054T1 (de) | 2004-10-15 |
| US20020013313A1 (en) | 2002-01-31 |
| JP4891510B2 (ja) | 2012-03-07 |
| AU2001240561A1 (en) | 2001-08-14 |
| CA2399377A1 (en) | 2001-08-09 |
| US6525045B2 (en) | 2003-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |