AR026360A1 - Benzotiazepinas substituidas no peptidicas como antagonistas de vasopresina - Google Patents
Benzotiazepinas substituidas no peptidicas como antagonistas de vasopresinaInfo
- Publication number
- AR026360A1 AR026360A1 ARP000105813A ARP000105813A AR026360A1 AR 026360 A1 AR026360 A1 AR 026360A1 AR P000105813 A ARP000105813 A AR P000105813A AR P000105813 A ARP000105813 A AR P000105813A AR 026360 A1 AR026360 A1 AR 026360A1
- Authority
- AR
- Argentina
- Prior art keywords
- heart failure
- substituted
- vasopresine
- benzotiazepins
- peptidic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente está dirigida a benzodiazepinas substituidas no peptídicas de formula (1), en la cual A, X, Z, Bp, W, n, R1 y R2 son tal como se han descriptoen la memoria, que son utiles como receptores de vasopresina para tratar condiciones que involuc ran el aumento de la resistencia vascular y la insuficienciacardíaca. También se han descripto composiciones farmacéuticas que comprenden un compuesto de formula (1) y los métodos para tratar las condiciones tales comohipertension, falla cardíaca con gestiva, insuficiencia cardíaca, vasoespasmo coronario, isquemia cardíaca, cirrosis hepática, vasoespasmo renal, falla renal,edema cerebral e isquemia, apoplejía, trombosis, o retencion de agua.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16354499P | 1999-11-04 | 1999-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR026360A1 true AR026360A1 (es) | 2003-02-05 |
Family
ID=22590503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000105813A AR026360A1 (es) | 1999-11-04 | 2000-11-03 | Benzotiazepinas substituidas no peptidicas como antagonistas de vasopresina |
Country Status (17)
Country | Link |
---|---|
US (1) | US6489321B1 (es) |
EP (1) | EP1226132A1 (es) |
JP (1) | JP2003513082A (es) |
KR (1) | KR20020047321A (es) |
CN (1) | CN1414958A (es) |
AR (1) | AR026360A1 (es) |
AU (1) | AU778810B2 (es) |
BR (1) | BR0015299A (es) |
CA (1) | CA2389439A1 (es) |
CZ (1) | CZ20021492A3 (es) |
HU (1) | HUP0204278A2 (es) |
MX (1) | MXPA02004513A (es) |
PL (1) | PL354759A1 (es) |
RU (1) | RU2002111660A (es) |
SK (1) | SK6052002A3 (es) |
WO (1) | WO2001032639A1 (es) |
YU (1) | YU32702A (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
JP3988832B2 (ja) * | 2004-11-29 | 2007-10-10 | 日本たばこ産業株式会社 | 窒素含有縮合環化合物及びその用途 |
JO3109B1 (ar) * | 2012-05-10 | 2017-09-20 | Ferring Bv | منبهات لمستقبلات v1a |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2751287B2 (ja) * | 1989-01-09 | 1998-05-18 | 吉富製薬株式会社 | 1,5‐ベンゾチアゼピン‐2‐カルボン酸アミド化合物 |
DK0450097T3 (da) * | 1989-10-20 | 1996-05-20 | Otsuka Pharma Co Ltd | Benzoheterocykliske forbindelser |
TW199153B (es) | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
JPH05320135A (ja) | 1992-05-19 | 1993-12-03 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロベンズアゼピン誘導体 |
JPH0680641A (ja) | 1992-09-01 | 1994-03-22 | Otsuka Pharmaceut Co Ltd | 光学活性な5−ヒドロキシベンゾアゼピン誘導体の製造法 |
SK94393A3 (en) | 1992-09-11 | 1994-08-10 | Thomae Gmbh Dr K | Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those |
WO1994022826A1 (en) | 1993-04-07 | 1994-10-13 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients |
MX9709875A (es) | 1995-06-06 | 1998-03-31 | Pfizer | N-(indol-2-carbonil)-glicinamidas substituidas y derivados como inhibidores de glicogeno fosforilasa, composiciones que las contienen y uso de las mismas. |
ATE205477T1 (de) | 1995-06-06 | 2001-09-15 | Pfizer | Substituierte n-(indol-2-carbonyl)-amide und derivate als glycogen phosphorylase inhibitoren |
ATE305781T1 (de) | 1996-02-23 | 2005-10-15 | Lilly Co Eli | Non-peptidische vasopressin via antagonisten |
DE59711622D1 (de) | 1996-09-10 | 2004-06-17 | Boehringer Ingelheim Pharma | Abgewandelte aminosäuren, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5952322A (en) | 1996-12-05 | 1999-09-14 | Pfizer Inc. | Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors |
US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
US6025372A (en) | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
DE19748763A1 (de) | 1997-11-05 | 1999-05-06 | Hans Peter Zenner | Verwendung von Vasopressin-Antagonisten |
AUPP150098A0 (en) | 1998-01-27 | 1998-02-19 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
DE69921124T2 (de) | 1998-06-12 | 2005-11-10 | Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. | Imidazolderivate und ihre verwendung als somatostatin rezeptorliganden |
US6552043B1 (en) | 1998-09-30 | 2003-04-22 | Merck Sharpe & Dohme Ltd. | Benzimidazolinyl piperidines as CGRP ligands |
GB9823873D0 (en) | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
-
2000
- 2000-11-02 KR KR1020027005650A patent/KR20020047321A/ko not_active Application Discontinuation
- 2000-11-02 JP JP2001534790A patent/JP2003513082A/ja active Pending
- 2000-11-02 CN CN00818031A patent/CN1414958A/zh active Pending
- 2000-11-02 US US09/704,314 patent/US6489321B1/en not_active Expired - Fee Related
- 2000-11-02 SK SK605-2002A patent/SK6052002A3/sk unknown
- 2000-11-02 HU HU0204278A patent/HUP0204278A2/hu unknown
- 2000-11-02 WO PCT/US2000/030114 patent/WO2001032639A1/en active IP Right Grant
- 2000-11-02 CZ CZ20021492A patent/CZ20021492A3/cs unknown
- 2000-11-02 EP EP00980254A patent/EP1226132A1/en not_active Withdrawn
- 2000-11-02 AU AU17540/01A patent/AU778810B2/en not_active Ceased
- 2000-11-02 PL PL00354759A patent/PL354759A1/xx not_active Application Discontinuation
- 2000-11-02 RU RU2002111660/04A patent/RU2002111660A/ru not_active Application Discontinuation
- 2000-11-02 CA CA002389439A patent/CA2389439A1/en not_active Abandoned
- 2000-11-02 BR BR0015299-4A patent/BR0015299A/pt not_active Application Discontinuation
- 2000-11-02 YU YU32702A patent/YU32702A/sh unknown
- 2000-11-02 MX MXPA02004513A patent/MXPA02004513A/es unknown
- 2000-11-03 AR ARP000105813A patent/AR026360A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN1414958A (zh) | 2003-04-30 |
AU778810B2 (en) | 2004-12-23 |
JP2003513082A (ja) | 2003-04-08 |
YU32702A (sh) | 2005-06-10 |
EP1226132A1 (en) | 2002-07-31 |
BR0015299A (pt) | 2003-04-15 |
CA2389439A1 (en) | 2001-05-10 |
HUP0204278A2 (hu) | 2003-04-28 |
US6489321B1 (en) | 2002-12-03 |
KR20020047321A (ko) | 2002-06-21 |
MXPA02004513A (es) | 2004-09-10 |
AU1754001A (en) | 2001-05-14 |
CZ20021492A3 (cs) | 2003-06-18 |
SK6052002A3 (en) | 2003-09-11 |
WO2001032639A1 (en) | 2001-05-10 |
RU2002111660A (ru) | 2003-11-27 |
PL354759A1 (en) | 2004-02-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |