AR020646A1 - Derivados de la piperazina con efecto antidiabetico, los procedimientos para su preparacion, las composiciones farmaceuticas que los contieneny el empleo de los mismos para preparar un medicamento - Google Patents

Derivados de la piperazina con efecto antidiabetico, los procedimientos para su preparacion, las composiciones farmaceuticas que los contieneny el empleo de los mismos para preparar un medicamento

Info

Publication number
AR020646A1
AR020646A1 ARP990103735A ARP990103735A AR020646A1 AR 020646 A1 AR020646 A1 AR 020646A1 AR P990103735 A ARP990103735 A AR P990103735A AR P990103735 A ARP990103735 A AR P990103735A AR 020646 A1 AR020646 A1 AR 020646A1
Authority
AR
Argentina
Prior art keywords
group
formula
piperazine
compound
halogen
Prior art date
Application number
ARP990103735A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR020646A1 publication Critical patent/AR020646A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Derivados de la piperazina de formula (1), en donde: n representa 2, 3, 4, 5 o 6; X representa O o S; Ar representa fenilo, piridilo, pirimidinilo,benzoxazolilo, benzotiazolilo y benzimidazolilo opcionalmente sustituidos con uno o más radicaleselegi dos entre un grupo de alcoxi C1-6, halogeno, ungrupo de ariloxi C6-10, un grupo de aril C6-10 alcoxi C1-6 en el cual la parte del arilo se encuentra opcionalmente sustituida con halogeno, alquilo C1-6o alcoxi C1-6; y un grupo de alquilo C1-6sustitui do con uno o más átomos de halogeno; i representa 0, 1, 2, 3 o 4; y cada grupo Z representaindependientemente un átomo de halogeno; se utilizan para el tratamiento de las patologías asociadas del síndrome de resistencia a la insulina.Unprocedimiento para preparar un compuesto de formula (1) en el cual se hace reaccionar un compuesto aromático de formula (2) con una piperazina deformula (3), formulas en las cuales Z, X, i, n y Ar tienen los significados indicados más arriba. P1es un grupo prote ctor de una funcion carboxiloy Grp1 es un grupo saliente, y luego se desprotege el compuesto resultante de la reaccion. Un procedimiento para preparar un compuesto de formula (1) en elcual se hace reaccionar una piperazina deformula (5) con un deriv ado carboxílico de formula (6), formulas en las cuales Z, X, i, n y Ar tienen lossignificados indicados más arriba; P2 es un grupo protector de una funcion carboxilo y Grp2 es un grupo saliente, y luego se desprotege elcompuesto resultantede la reac cion
ARP990103735A 1998-07-28 1999-07-28 Derivados de la piperazina con efecto antidiabetico, los procedimientos para su preparacion, las composiciones farmaceuticas que los contieneny el empleo de los mismos para preparar un medicamento AR020646A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9809660A FR2781797B1 (fr) 1998-07-28 1998-07-28 Derives de piperazine antidiabetiques, leurs procedes de preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR020646A1 true AR020646A1 (es) 2002-05-22

Family

ID=9529125

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103735A AR020646A1 (es) 1998-07-28 1999-07-28 Derivados de la piperazina con efecto antidiabetico, los procedimientos para su preparacion, las composiciones farmaceuticas que los contieneny el empleo de los mismos para preparar un medicamento

Country Status (17)

Country Link
US (1) US6376495B1 (es)
EP (1) EP1100790A1 (es)
JP (1) JP2002521477A (es)
KR (1) KR20010072775A (es)
AR (1) AR020646A1 (es)
AU (1) AU752993B2 (es)
BR (1) BR9913149A (es)
CA (1) CA2338694A1 (es)
FR (1) FR2781797B1 (es)
HU (1) HUP0102830A3 (es)
NO (1) NO20010469L (es)
PL (1) PL345735A1 (es)
RU (1) RU2208610C2 (es)
SK (1) SK1142001A3 (es)
TW (1) TW472046B (es)
WO (1) WO2000006558A1 (es)
ZA (1) ZA200102495B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2372715A1 (en) * 1999-05-13 2001-04-12 Shionogi & Co., Ltd. Preventive or therapeutic drugs for diabetes
FR2829765A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives imidazolylalkoxylarylalcanoiques leurs applications en therapeutique
AU2006282403B2 (en) 2005-08-26 2011-07-07 Institute Of Medicinal Molecular Design, Inc. Derivative having PPAR agonistic activity
JP2008239616A (ja) * 2007-02-28 2008-10-09 Iyaku Bunshi Sekkei Kenkyusho:Kk Ｈｄｌ上昇剤
CN102485717B (zh) 2010-12-06 2015-12-02 中国人民解放军军事医学科学院毒物药物研究所 噻唑胺衍生物及其作为抗小rna病毒感染药物的用途
FR2976943B1 (fr) * 2011-06-23 2013-07-12 Metabolys Derives de piperazine, leurs procedes de preparation et leurs utilisations dans le traitement de l'insulinoresistance
FR2976942B1 (fr) * 2011-06-23 2013-07-12 Metabolys Derives de piperazine, leurs procedes de preparation et leurs utilisations dans le traitement de l'insulinoresistance
FR2999427B1 (fr) 2012-12-17 2015-01-30 Metabolys Composition et kit comprenant des derives de piperazine et de la metformine, leur utilisation dans le traitement du diabete

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277094A (en) * 1965-05-10 1966-10-04 Ciba Geigy Corp Piperazine derivatives
US3951983A (en) * 1970-11-10 1976-04-20 Pfizer Inc. Phenoxypropanolpiperazines
DE3564683D1 (en) * 1984-08-07 1988-10-06 Cortial 4-(arylpiperazinylethylaminoethoxy) phenol derivatives, process for their preparation and their therapeutical application
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists

Also Published As

Publication number Publication date
RU2208610C2 (ru) 2003-07-20
NO20010469D0 (no) 2001-01-26
CA2338694A1 (en) 2000-02-10
PL345735A1 (en) 2002-01-02
NO20010469L (no) 2001-01-26
SK1142001A3 (en) 2001-09-11
HUP0102830A3 (en) 2002-12-28
US6376495B1 (en) 2002-04-23
FR2781797B1 (fr) 2000-11-03
AU752993B2 (en) 2002-10-03
EP1100790A1 (en) 2001-05-23
HUP0102830A2 (hu) 2001-12-28
ZA200102495B (en) 2002-09-27
WO2000006558A1 (en) 2000-02-10
BR9913149A (pt) 2003-01-21
KR20010072775A (ko) 2001-07-31
AU5160999A (en) 2000-02-21
FR2781797A1 (fr) 2000-02-04
JP2002521477A (ja) 2002-07-16
TW472046B (en) 2002-01-11

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