AR020138A1 - COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO. - Google Patents

COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO.

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Publication number
AR020138A1
AR020138A1 ARP990103957A ARP990103957A AR020138A1 AR 020138 A1 AR020138 A1 AR 020138A1 AR P990103957 A ARP990103957 A AR P990103957A AR P990103957 A ARP990103957 A AR P990103957A AR 020138 A1 AR020138 A1 AR 020138A1
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Argentina
Prior art keywords
alkyl
group
alkoxy
arylalkyl
cycloalkyl
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ARP990103957A
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English (en)
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Abbott Lab
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Publication of AR020138A1 publication Critical patent/AR020138A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuesto que tiene la formula 1: amida éster o prodroga aceptable para uso farmacéutico, donde R1 se selecciona del grupo formado por -S(O)2R9 y -C(O)R10;R9 se selecciona del grupo que consiste de alquenilo C2-10, alquilo C1-10, alquinilo C2-10, arilo, arilalquenilo C2-5, arilalquilo C2-5, cicloalquilo C3-8,cicloalquil C3-7 alquilo C1-4, haloalquilo C1-5, heterociclo mono y bi-ciclo, y -NZ1Z2 donde Z1 y Z2 se seleccionan independientemente del grupo formado porhidrogeno, alquilo C1-10, alquil C1-4 carbonilo, arilo, arilalquilo C2-5, y formilo; R10 se selecciona del grupo formado por alquenilo C2-10, alcoxi C1-6,alquilo C1-10, alquinilo C2-10, arilo, arilalquilo C2-5, cicloalquilo C3-8, cicloalquil C3-7 alquilo C1-5, halo C1-5, y -NZ1Z2 definido precedentemente; R2 seselecciona del grupo formado por hidrogeno, alquenilo C2-10, alcoxi C1-6, alquilo C1-10, halo, halo C1-5 alquilo C1-5, e hidroxi; R3 se selecciona del grupoformado por alqueniloxi C2-5, alquilo C1-10, alcoxi C1-6, alcoxi C1-4 alquilo C1-4, alquinil C1-4 oxi, arilalquilo C2-5, cicloalquil C3-7 alquilo C1-4, haloC1-5 alquilo C1-5, e hidroxi; con la condicion de que cuando R3 es seleccionado del grupo que consiste de alqueniloxi, alquilo, alcoxi, alcoxi-alquilo-alquinil-oxi, aril-alquilo, ciclaoalquil-alquilo, halo-alquilo e hidroxi, con los alcances indicados precedentemente, entonces R4 es seleccionado del grupo queconsiste de hidrogeno, alquilo C1-10, alcoxi C1-6, halo C1-5, e hidroxi; o R3 y R4 junto con los átomos de carbono a los cuales se encuentran unidos forman unanillo carbocíclico de 5, 6 o 7 miembros; o R3 y R4 junto con los átomos de carbono a los cuales se encuentran unidos forman un anillo de 5 o 6 miembros quecontiene 1 heteroátomo seleccionadodel grupo formado por O, NR11, y S(O)n; R11 se selecciona del grupo formado por hidrogneo, alquenilo C2-10, alcoxi C1-4,carbonilo, alquilo C1-10, alquil C1-4, carbonilo, alquinilo C2-10, arilalquilo C2-5, formilo, -C(O)NZ1Z2, y -SO2NZ1Z2; n es 0-2: R5 se selecciona del grupoformado por imidazol-4-ilo, imidazol-5-ilo, pirazol, oxazol, isoxazol, tiazol, isotiazol, oxidiazol, triazol, tiadiazol, piridina, pirimidina, pirazina y
ARP990103957A 1998-08-07 1999-08-06 COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO. AR020138A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13079998A 1998-08-07 1998-08-07
US09/364,901 US6503935B1 (en) 1998-08-07 1999-07-29 Imidazoles and related compounds as α1A agonists

Publications (1)

Publication Number Publication Date
AR020138A1 true AR020138A1 (es) 2002-04-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103957A AR020138A1 (es) 1998-08-07 1999-08-06 COMPUESTOS DERIVADOS DE N-{3-[1-(1H-IMIDAZOL-4-IL)-ALQUIL C1-4]-fenil}-ALCAN-SULFONAMIDA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y METODO PARA ACTIVARADRENO RECEPTORES a1 EN UN MAMIFERO.

Country Status (8)

Country Link
US (1) US6503935B1 (es)
EP (1) EP1102754A1 (es)
JP (1) JP2002522423A (es)
AR (1) AR020138A1 (es)
AU (1) AU5338699A (es)
CA (1) CA2338594A1 (es)
TW (1) TW517050B (es)
WO (1) WO2000007997A1 (es)

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Also Published As

Publication number Publication date
JP2002522423A (ja) 2002-07-23
EP1102754A1 (en) 2001-05-30
AU5338699A (en) 2000-02-28
US6503935B1 (en) 2003-01-07
CA2338594A1 (en) 2000-02-17
WO2000007997A1 (en) 2000-02-17
TW517050B (en) 2003-01-11
WO2000007997A8 (en) 2000-05-04

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