AR019669A1 - Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen. - Google Patents
Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen.Info
- Publication number
- AR019669A1 AR019669A1 ARP990102861A ARP990102861A AR019669A1 AR 019669 A1 AR019669 A1 AR 019669A1 AR P990102861 A ARP990102861 A AR P990102861A AR P990102861 A ARP990102861 A AR P990102861A AR 019669 A1 AR019669 A1 AR 019669A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- aryl
- hydrogen atom
- preparation
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Uso para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales está involucrado por lo menos uno de losreceptores de somatostatina, de diazepinas de formula general (1) en el cual W representa el átomode hidrogeno o un radical de formula R-X-C(Y), R representaun radical arilo o heteroarilo, estando los radicales arilo y heteroarilo sustituidos optativamente; X representa un radical de formula -(CH2)n-Z en el cual Zrepresenta un enlace covalente,NH, O o S y n es un entero de 0 y 2; Y representa O o S, R1 representa uno o más grupos idénticos o diferentes, elegidos entre:un átomo de hidrogeno, hidroxi, un radical halo, un radical alquilo inferior y alcoxi inferior; R2a y R2b representan, independientemente, un átomo dehidrogeno; un radical alquilo inferior, alquenilo inferior o alquinilo inferior, estando los radicales alquilo, alquenilo y alquinilo optativamente sustituidoso un radical R21Z21- en el cual Z21 representa O, C(O), OC(O), S, R21 representa un átomo de hidrogeno, un radical alquilo, arilo o arilalquilo inferior; R3representa un átomo de hidrogeno, un radical halo, nitro o ciano, un radical alquilo con 1 a 10 átomos de carbono, radicales alquenilo inferior, alquiniloinferior, cicloalquilo, cicloalquilalquilo, arilo, arilalquilo, ariloxialquilo inferior, heteroarilo o heteroarilalquilo, estando los radicales alquilo,alquenilo, alquilo, cicloalquilo, arilo y heteroarilo optativamente sustituidos; o un radical R31Z31-en el cual Z31 representa O, C(O), OC(O), S, y R31representa un átomo de hidrogeno, un radical alquilo inferior, arilo o arilalquilo inferior , o una sal de este producto, para la preparacion de un medicamentopara tratar estados patologicos o enfermedades en las cuales están involucrados uno (o más) receptores de somatostatina. Dado que los desordenes patologicosasociados con la somatostatina son numerosos, resulto importante hallar compuesto que tengan afinidad con receptores de somatostatina.Como nuevos compuestoscomprendidos por la formula (1), se encuentran los de la formula general (2) en la cual W representa el átomo de hidrogeno o un radical de formula
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9807509A FR2779652B1 (fr) | 1998-06-15 | 1998-06-15 | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR019669A1 true AR019669A1 (es) | 2002-03-13 |
Family
ID=9527389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102861A AR019669A1 (es) | 1998-06-15 | 1999-06-15 | Uso de diazepinas para la preparacion de medicamentos para el tratamiento de estados patologicos o enfermedades en los cuales esta involucrado por lo menosuno de los receptores de somatostatina, diazepinas utilizadas en dicha preparacion y medicamento y composicion farmaceutica que los contienen. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7015213B1 (es) |
| EP (1) | EP1087978A1 (es) |
| JP (1) | JP2002518400A (es) |
| KR (1) | KR20010052836A (es) |
| CN (1) | CN100348600C (es) |
| AR (1) | AR019669A1 (es) |
| AU (1) | AU758206B2 (es) |
| CA (1) | CA2335724A1 (es) |
| FR (1) | FR2779652B1 (es) |
| HK (1) | HK1039780A1 (es) |
| HU (1) | HUP0102300A3 (es) |
| IL (1) | IL139954A0 (es) |
| MY (1) | MY118652A (es) |
| NO (1) | NO20006352D0 (es) |
| NZ (1) | NZ509313A (es) |
| PL (1) | PL344831A1 (es) |
| RU (1) | RU2229299C2 (es) |
| TW (1) | TW513434B (es) |
| WO (1) | WO1999065917A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001083440A2 (en) * | 2000-04-28 | 2001-11-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of thienotriazolodiazepines |
| WO2002057241A1 (en) * | 2000-12-22 | 2002-07-25 | Bayer Pharmaceuticals Corporation | 8-(AMINOALKOXYMINO)-8H-DIBENZO[a,e]TRIAZOLO[4,5-c]CYCLOHEPTENES AS GROWTH HORMONE SECRETAGOGUES |
| JP5478262B2 (ja) * | 2007-12-28 | 2014-04-23 | 田辺三菱製薬株式会社 | 抗癌剤 |
| CN105582014B (zh) | 2010-05-14 | 2019-06-14 | 达那-法伯癌症研究所 | 用于治疗白血病的组合物和方法 |
| DK2571503T3 (en) | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| US9301962B2 (en) | 2010-05-14 | 2016-04-05 | Baylor College Of Medicine | Male contraceptive compositions and methods of use |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| WO2013184878A1 (en) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof |
| MX2016001037A (es) | 2013-07-25 | 2016-11-10 | Dana Farber Cancer Inst Inc | Inhibidores de factores de transcripción y usos. |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| WO2015117053A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| CN106456653A (zh) * | 2014-02-28 | 2017-02-22 | 腾沙治疗公司 | 高胰岛素血症相关病症的治疗 |
| US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| EP3177147A4 (en) | 2014-08-08 | 2018-01-24 | Dana-Farber Cancer Institute, Inc. | Dihydropteridinone derivatives and uses thereof |
| KR20170068597A (ko) | 2014-10-27 | 2017-06-19 | 텐샤 세러퓨틱스 인코포레이티드 | 브로모도메인 저해제 |
| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| AU2016319116B2 (en) * | 2015-09-11 | 2020-10-01 | Dana-Farber Cancer Institute, Inc. | Cyano thienotriazolodiazepines and uses thereof |
| SG10202007099TA (en) | 2015-09-11 | 2020-08-28 | Dana Farber Cancer Inst Inc | Acetamide thienotriazoldiazepines and uses thereof |
| KR20180081809A (ko) | 2015-11-25 | 2018-07-17 | 다나-파버 캔서 인스티튜트 인크. | 2가 브로모도메인 억제제 및 그의 용도 |
| PL3680243T3 (pl) * | 2017-09-07 | 2022-02-14 | Eisai R&D Management Co., Ltd. | Związek pentacykliczny |
| EA202191966A1 (ru) | 2019-03-05 | 2021-12-08 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Пентациклическое гетероциклическое соединение |
| EP3936189A4 (en) | 2019-03-05 | 2022-12-14 | Eisai R&D Management Co., Ltd. | SALT OF A PENTACYCLIC COMPOUND AND CRYSTALS THEREOF |
| CN111533745A (zh) * | 2020-05-20 | 2020-08-14 | 成都药明康德新药开发有限公司 | 叔丁基-3-(氨基甲基)二氢-5h-三唑并二氮杂卓-8(9h)-甲酸基酯制法 |
| CR20230211A (es) | 2020-11-16 | 2023-07-13 | Boehringer Ingelheim Int | Derivados de ciclopentatiofen carboxamida como antagonistas del receptor del factor de activación de plaquetas |
| WO2023117914A1 (en) | 2021-12-22 | 2023-06-29 | Boehringer Ingelheim International Gmbh | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95708C (fi) * | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| GB8907256D0 (en) * | 1989-03-31 | 1989-05-17 | Rech Et D Applic Scient Scras | New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors |
| OA09202A (fr) * | 1990-04-02 | 1992-06-30 | Sod Conseils Rech Applic | Procédé de préparation des nouveaux dérivés de la thiéno-triazolo-diazépine. |
| DE4107521A1 (de) * | 1991-03-08 | 1992-09-10 | Boehringer Ingelheim Kg | Neue acylaminosubstituierte hetrazepine |
| WO1993007129A1 (en) * | 1991-10-11 | 1993-04-15 | Yoshitomi Pharmaceutical Industries, Ltd. | Remedy for osteoporosis and diazepine compound |
| AU4772497A (en) * | 1996-10-31 | 1998-05-22 | Novo Nordisk A/S | Constrained somatostatin agonists and antagonists |
-
1998
- 1998-06-15 FR FR9807509A patent/FR2779652B1/fr not_active Expired - Fee Related
-
1999
- 1999-06-15 AU AU41495/99A patent/AU758206B2/en not_active Ceased
- 1999-06-15 MY MYPI99002451A patent/MY118652A/en unknown
- 1999-06-15 CN CNB998087092A patent/CN100348600C/zh not_active Expired - Fee Related
- 1999-06-15 HU HU0102300A patent/HUP0102300A3/hu unknown
- 1999-06-15 IL IL13995499A patent/IL139954A0/xx not_active IP Right Cessation
- 1999-06-15 US US09/701,893 patent/US7015213B1/en not_active Expired - Fee Related
- 1999-06-15 JP JP2000554742A patent/JP2002518400A/ja active Pending
- 1999-06-15 RU RU2001101481/15A patent/RU2229299C2/ru not_active IP Right Cessation
- 1999-06-15 CA CA002335724A patent/CA2335724A1/fr not_active Abandoned
- 1999-06-15 WO PCT/FR1999/001422 patent/WO1999065917A1/fr not_active Application Discontinuation
- 1999-06-15 NZ NZ509313A patent/NZ509313A/xx unknown
- 1999-06-15 AR ARP990102861A patent/AR019669A1/es unknown
- 1999-06-15 PL PL99344831A patent/PL344831A1/xx unknown
- 1999-06-15 EP EP99925093A patent/EP1087978A1/fr not_active Withdrawn
- 1999-06-15 KR KR1020007014166A patent/KR20010052836A/ko not_active Application Discontinuation
- 1999-07-30 TW TW088109993A patent/TW513434B/zh not_active IP Right Cessation
-
2000
- 2000-12-13 NO NO20006352A patent/NO20006352D0/no not_active Application Discontinuation
-
2002
- 2002-02-22 HK HK02101333.2A patent/HK1039780A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002518400A (ja) | 2002-06-25 |
| CN100348600C (zh) | 2007-11-14 |
| AU4149599A (en) | 2000-01-05 |
| FR2779652A1 (fr) | 1999-12-17 |
| NZ509313A (en) | 2002-11-26 |
| NO20006352L (no) | 2000-12-13 |
| AU758206B2 (en) | 2003-03-20 |
| HUP0102300A2 (hu) | 2001-11-28 |
| CN1309657A (zh) | 2001-08-22 |
| NO20006352D0 (no) | 2000-12-13 |
| KR20010052836A (ko) | 2001-06-25 |
| TW513434B (en) | 2002-12-11 |
| PL344831A1 (en) | 2001-11-19 |
| IL139954A0 (en) | 2002-02-10 |
| WO1999065917A1 (fr) | 1999-12-23 |
| CA2335724A1 (fr) | 1999-12-23 |
| FR2779652B1 (fr) | 2001-06-08 |
| HUP0102300A3 (en) | 2002-10-28 |
| EP1087978A1 (fr) | 2001-04-04 |
| MY118652A (en) | 2004-12-31 |
| US7015213B1 (en) | 2006-03-21 |
| RU2229299C2 (ru) | 2004-05-27 |
| HK1039780A1 (zh) | 2002-05-10 |
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