AR019114A1 - Nuevas microesferas a base de poli(metiliden malonato), su procedimiento de preparacion y composiciones farmaceuticas que las contienen - Google Patents

Nuevas microesferas a base de poli(metiliden malonato), su procedimiento de preparacion y composiciones farmaceuticas que las contienen

Info

Publication number
AR019114A1
AR019114A1 ARP990101963A ARP990101963A AR019114A1 AR 019114 A1 AR019114 A1 AR 019114A1 AR P990101963 A ARP990101963 A AR P990101963A AR P990101963 A ARP990101963 A AR P990101963A AR 019114 A1 AR019114 A1 AR 019114A1
Authority
AR
Argentina
Prior art keywords
methylid
poli
malonate
pharmaceutical compositions
compositions containing
Prior art date
Application number
ARP990101963A
Other languages
English (en)
Original Assignee
Virsol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virsol filed Critical Virsol
Publication of AR019114A1 publication Critical patent/AR019114A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2335/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Nuevas microesferas especialmente utiles en el campo farmacéutico como vectores particulares destinados al transporte de sustancias biologicamente activas,en particular sustancias hidrofilas, con miras a una administracion oral. Dichas microesferas están constituidas por una red contínua de un material de soporteen el cual está eventualmente dispersa una sustancia, conteniendo dicho material de soporte al menos 70% de peso de un homopolímero constituido por unidadesrecurrentes que responden a laformula general (I) en la cual: R1 representa un grupo alquilo que tiene de 1 a 6 átomos de carbono o un grupo (CH2)n-COOR3 enel cual m es un numero entero comprendido entre 1 y 5 y R3 representa un grupo alquilo que tiene de 1 a 6 átomos de carbono; R2 representa un grupo alquilo quetiene de 1 a 6 átomos de carbono; y n es un numero entero comprendido entre 1 y 5. Aplicacion: Campo farmacéutico.
ARP990101963A 1998-04-29 1999-04-28 Nuevas microesferas a base de poli(metiliden malonato), su procedimiento de preparacion y composiciones farmaceuticas que las contienen AR019114A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9805424A FR2778100B1 (fr) 1998-04-29 1998-04-29 Nouvelles microspheres a base de poly(methylidene malonate), leur procede de preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AR019114A1 true AR019114A1 (es) 2001-12-26

Family

ID=9525849

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990101963A AR019114A1 (es) 1998-04-29 1999-04-28 Nuevas microesferas a base de poli(metiliden malonato), su procedimiento de preparacion y composiciones farmaceuticas que las contienen

Country Status (15)

Country Link
US (1) US6440461B1 (es)
EP (1) EP1082104A1 (es)
JP (1) JP2002513042A (es)
KR (1) KR20010043060A (es)
CN (1) CN1146408C (es)
AR (1) AR019114A1 (es)
AU (1) AU752644B2 (es)
BR (1) BR9910016A (es)
CA (1) CA2330481A1 (es)
FR (1) FR2778100B1 (es)
HU (1) HUP0101649A3 (es)
PL (1) PL343687A1 (es)
RU (1) RU2227018C2 (es)
SK (1) SK16312000A3 (es)
WO (1) WO1999055309A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4611561B2 (ja) * 2000-04-12 2011-01-12 Ｄｉｃ株式会社 新規なビニル系樹脂およびその製造方法
FR2812551B1 (fr) * 2000-08-07 2003-03-28 Virsol Forme pharmaceutique comprenant un materiau support a base de methylidene malonate et un facteur de regulation cellulaire
US20030008015A1 (en) * 2000-10-11 2003-01-09 Levisage Catherine S. Polymer controlled delivery of a therapeutic agent
US8598092B2 (en) * 2005-02-02 2013-12-03 Halliburton Energy Services, Inc. Methods of preparing degradable materials and methods of use in subterranean formations
JP5339673B2 (ja) * 2006-08-31 2013-11-13 キヤノン株式会社 微粒子の製造方法
US8975435B2 (en) 2009-05-07 2015-03-10 Optmed, Inc. Methylidene malonate process
US8106234B2 (en) * 2009-05-07 2012-01-31 OptMed, Inc Methylidene malonate process
WO2011008863A2 (en) * 2009-07-14 2011-01-20 Lucia Irene Gonzalez Stereoisomer peptides and their polymer conjugates for hiv disease
WO2011059779A2 (en) * 2009-10-29 2011-05-19 Lucia Irene Gonzalez Ligand-targeted multi- stereoisomer peptide polymer conjugates and uses thereof
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
SG189937A1 (en) 2010-10-20 2013-06-28 Bioformix Inc Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent
JP6267643B2 (ja) 2011-10-19 2018-01-24 シラス・インコーポレイテッド 多官能性モノマー、多官能性モノマーを製造する方法、これらから形成された重合性組成物および製品
EP2831125B1 (en) 2012-03-30 2016-10-05 Sirrus, Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
WO2013149173A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Ink and coating formulations and polymerizable systems for producing the same
EP2831124B1 (en) 2012-03-30 2016-10-05 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
EP2920231B1 (en) 2012-11-16 2020-05-06 Sirrus, Inc. Plastics bonding systems and methods
JP6549038B2 (ja) 2012-11-30 2019-07-24 シラス・インコーポレイテッド エレクトロニクス適用のための複合組成物
EP2943462B1 (en) 2013-01-11 2018-06-27 Sirrus, Inc. Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
CA3064314A1 (en) 2017-06-02 2018-12-06 Arkema France Curable compositions and uses thereof
CN112055580B (zh) * 2018-07-25 2024-01-09 弗门尼舍有限公司 制备微胶囊的方法
WO2020123579A1 (en) * 2018-12-11 2020-06-18 Sirrus, Inc. Polymerization of 1,1-dicarbonyl 1-alkenes
CN114127220B (zh) 2019-07-19 2024-01-19 阿科玛法国公司 可用于获得非致敏性的固化产品的可固化组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
DE19508049C2 (de) 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
FR2755136B1 (fr) * 1996-10-25 1999-01-22 Virsol Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
EP1082104A1 (fr) 2001-03-14
FR2778100B1 (fr) 2001-05-04
WO1999055309A1 (fr) 1999-11-04
US6440461B1 (en) 2002-08-27
BR9910016A (pt) 2001-01-09
CA2330481A1 (en) 1999-11-04
AU3428899A (en) 1999-11-16
RU2227018C2 (ru) 2004-04-20
SK16312000A3 (sk) 2001-04-09
HUP0101649A2 (hu) 2002-03-28
FR2778100A1 (fr) 1999-11-05
JP2002513042A (ja) 2002-05-08
CN1303274A (zh) 2001-07-11
HUP0101649A3 (en) 2002-10-28
KR20010043060A (ko) 2001-05-25
CN1146408C (zh) 2004-04-21
PL343687A1 (en) 2001-08-27
AU752644B2 (en) 2002-09-26

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