AR018431A1 - Uso de un compuesto para inhibir el enlace de un peptido beta amiloide con receptores de acetilcolina nicotinicos alfa-7 para la preparacion de un medicamento, un metodo para identificar compuestos que son utiles para el tratamiento de desordenes neurodegenerativos, derivados de tetrahidronaftaleno, - Google Patents

Uso de un compuesto para inhibir el enlace de un peptido beta amiloide con receptores de acetilcolina nicotinicos alfa-7 para la preparacion de un medicamento, un metodo para identificar compuestos que son utiles para el tratamiento de desordenes neurodegenerativos, derivados de tetrahidronaftaleno,

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Publication number
AR018431A1
AR018431A1 ARP990102580A ARP990102580A AR018431A1 AR 018431 A1 AR018431 A1 AR 018431A1 AR P990102580 A ARP990102580 A AR P990102580A AR P990102580 A ARP990102580 A AR P990102580A AR 018431 A1 AR018431 A1 AR 018431A1
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Argentina
Prior art keywords
treatment
useful
compound
inhibit
preparation
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ARP990102580A
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English (en)
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Ortho Mcneil Pharm Inc
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Publication of AR018431A1 publication Critical patent/AR018431A1/es

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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C323/24Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract

El uso de un compuesto para inhibir el enlace de un péptido beta amiloide con receptores de acetilcolina nicotinicos alfa-7 para la preparacion de unmedicamento util para el tratamiento de un desorden neurodegenerativo en un sujeto que lo necesita, que comprende una cantidad de un compuesto efectiva; unmétodo para identificar compuestos que son utiles para el tratamiento de desordenes neurodegenerativos, derivados de tetrahidronaftaleno, una composicionfarmacéutica y un método para diagnosticarla enfermedad Alzheimer.
ARP990102580A 1998-06-01 1999-06-01 Uso de un compuesto para inhibir el enlace de un peptido beta amiloide con receptores de acetilcolina nicotinicos alfa-7 para la preparacion de un medicamento, un metodo para identificar compuestos que son utiles para el tratamiento de desordenes neurodegenerativos, derivados de tetrahidronaftaleno, AR018431A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8757798P 1998-06-01 1998-06-01

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AR018431A1 true AR018431A1 (es) 2001-11-14

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ARP990102580A AR018431A1 (es) 1998-06-01 1999-06-01 Uso de un compuesto para inhibir el enlace de un peptido beta amiloide con receptores de acetilcolina nicotinicos alfa-7 para la preparacion de un medicamento, un metodo para identificar compuestos que son utiles para el tratamiento de desordenes neurodegenerativos, derivados de tetrahidronaftaleno,

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US (2) US6441049B2 (es)
EP (1) EP1083889B1 (es)
JP (1) JP4637351B2 (es)
AR (1) AR018431A1 (es)
AT (1) ATE255888T1 (es)
AU (1) AU765142B2 (es)
CA (1) CA2333951C (es)
DE (1) DE69913520T2 (es)
DK (1) DK1083889T3 (es)
ES (1) ES2212570T3 (es)
PT (1) PT1083889E (es)
WO (1) WO1999062505A2 (es)

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US6441049B2 (en) 2002-08-27
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US20030130165A1 (en) 2003-07-10
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DE69913520D1 (de) 2004-01-22
EP1083889B1 (en) 2003-12-10
US20020013374A1 (en) 2002-01-31
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