AR018033A1 - Analogos 13-oxa prostaglandinas, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento - Google Patents
Analogos 13-oxa prostaglandinas, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamentoInfo
- Publication number
- AR018033A1 AR018033A1 ARP980106610A ARP980106610A AR018033A1 AR 018033 A1 AR018033 A1 AR 018033A1 AR P980106610 A ARP980106610 A AR P980106610A AR P980106610 A ARP980106610 A AR P980106610A AR 018033 A1 AR018033 A1 AR 018033A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- acyl
- acyloxy
- alkoxy
- oxa
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002252 acyl group Chemical group 0.000 abstract 6
- 125000004423 acyloxy group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical compound S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 235000019256 formaldehyde Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Uso de análogos 13-oxa prostaglandinas para la manufactura de un medicamento util para tratar el glaucoma o la hipertension ocular en un paciente, queconsiste en una cantidad farmacéuticamente efectiva de un compuesto de la formula (I) en la cual: R1es CO2R, CONR4R5, CH2OR6 o CH2NR7R8; R es H o una porcionsal cationica, o CO2R conforma una porcion éster farmacéuticamente aceptable; R4 y R5, iguales o diferentes, son H o alquilo; R6 es H, acilo o alquilo; R7 yR8, iguales o diferentes, son H, acilo o alquilo; con la condicion de que si uno de R7 y R8 es acilo, el otro es H o alquilo; n es 0 o 2; G es CH2 o O; R2 yR3, iguales o diferentes, son OH, aciloxi, alcoxi, carbonilo, halogeno, H, con la condicion de que por lo menos uno de R2 y R3 seaOH, aciloxi, alcoxi ocarbonilo; la línea punteada es un enlace simple o doble o no acumulado; uno de A y B es H, el otro es halo, OH, aciloxi o alcoxi; o A y B juntos son O(CH2)2Oo O con doble enlace; X es (CH2)q o (CH2)qO, donde q es 1-6; Y es un anillo de fenilo optativamente sustituido con alquilo, halo, trihalometilo, alcoxi, acilo,aciloxi, amino, alquilamino, acilamino o hidroxi; o X e Y juntos son (CH2)pY1, donde p es 0-6 e Y1 es seleccionado del grupo de formulas (II) donde: W es CH2,O,S(O)m, NR9, CH2CH2, CH=CH, CH2O, CH2S(O)m, CH=N o CH2NR9, donde m es 0-2 y R9 es H, alquilo o acilo; Z es H, alquilo, alcoxi, acilo, aciloxi, halo,trihalometilo, amino, alquilamino, acilamino o hidroxi, y la línea punteada es un enlace simple o dobleo X e Y juntos son ciclohexilo o ciclopentilo; dichosanálogos 13-oxa y composicion farmacéutica que los contiene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6846197P | 1997-12-22 | 1997-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018033A1 true AR018033A1 (es) | 2001-10-31 |
Family
ID=22082733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106610A AR018033A1 (es) | 1997-12-22 | 1998-12-22 | Analogos 13-oxa prostaglandinas, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6232344B1 (es) |
| AR (1) | AR018033A1 (es) |
| AU (1) | AU1709699A (es) |
| WO (1) | WO1999032441A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01008955A (es) | 1999-03-05 | 2002-04-24 | Procter & Gamble | Analogos de prostaglandinas selectivas de fp no saturadas de c16. |
| CN100506232C (zh) * | 2000-03-16 | 2009-07-01 | 苏坎波公司 | 用于治疗眼压过高和青光眼的组合物 |
| US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US20030199590A1 (en) * | 2002-07-25 | 2003-10-23 | Cagle Gerald D | Prostaglandin analogues for promotion of hair growth |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) * | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| CA2929545C (en) | 2009-05-01 | 2019-04-09 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| KR20170095402A (ko) | 2009-11-09 | 2017-08-22 | 알러간, 인코포레이티드 | 모발 성장을 촉진하기 위한 조성물 및 방법 |
| EP2982373B1 (en) | 2011-01-19 | 2018-06-13 | Topokine Therapeutics, Inc. | Methods and compostions for reducing body fat |
| US8859616B2 (en) | 2011-01-21 | 2014-10-14 | Allergan, Inc. | Compounds and methods for enhancing hair growth |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| PL3811943T3 (pl) | 2013-03-15 | 2023-06-12 | Aerie Pharmaceuticals, Inc. | Związek do stosowania w leczeniu zaburzeń oczu |
| NO2753788T3 (es) | 2013-05-10 | 2018-06-16 | ||
| US9820993B2 (en) | 2013-05-15 | 2017-11-21 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US11389441B2 (en) | 2016-08-31 | 2022-07-19 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
| JP2020515583A (ja) | 2017-03-31 | 2020-05-28 | アエリエ ファーマシューティカルズ インコーポレイテッド | アリールシクロプロピル−アミノ−イソキノリニルアミド化合物 |
| CA3112391A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| GB8410396D0 (en) | 1984-04-24 | 1984-05-31 | Glaxo Group Ltd | Carbocyclic compounds |
| GB8510277D0 (en) | 1985-04-23 | 1985-05-30 | Glaxo Group Ltd | Carbocyclic compounds |
| GB8625322D0 (en) | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| GB8625321D0 (en) * | 1986-10-22 | 1986-11-26 | Glaxo Group Ltd | Chemical compounds |
| US5321128A (en) | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5093329A (en) | 1990-03-12 | 1992-03-03 | Allergan, Inc. | Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives |
| EP0561073B1 (en) | 1992-03-19 | 2001-10-24 | R-Tech Ueno Ltd. | Treatment of ocular hypertension with beta-blockers and derivatives of prostanoic acid |
| DE4229050A1 (de) | 1992-08-31 | 1994-03-03 | Schering Ag | Neue 9-Chlor-Prostaglandin-Ester und -amide |
| JP3032302B2 (ja) * | 1995-12-22 | 2000-04-17 | アルコン ラボラトリーズ，インコーポレイテッド | 眼圧降下剤としてのプロスタグランジンの置換テトラヒドロフランアナログ |
-
1998
- 1998-12-04 US US09/308,610 patent/US6232344B1/en not_active Expired - Fee Related
- 1998-12-04 AU AU17096/99A patent/AU1709699A/en not_active Abandoned
- 1998-12-04 WO PCT/US1998/025681 patent/WO1999032441A1/en active Application Filing
- 1998-12-22 AR ARP980106610A patent/AR018033A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1709699A (en) | 1999-07-12 |
| WO1999032441A1 (en) | 1999-07-01 |
| US6232344B1 (en) | 2001-05-15 |
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