AR012293A1 - Derivado de pirimidina y agentes para tratar una enfermedad alergica, asma o dermatitis atopica y para producir inhibicion de no, tnf-alfa, citocinas o5-lipoxigenasa que lo comprenden. - Google Patents
Derivado de pirimidina y agentes para tratar una enfermedad alergica, asma o dermatitis atopica y para producir inhibicion de no, tnf-alfa, citocinas o5-lipoxigenasa que lo comprenden.Info
- Publication number
- AR012293A1 AR012293A1 ARP980101135A ARP980101135A AR012293A1 AR 012293 A1 AR012293 A1 AR 012293A1 AR P980101135 A ARP980101135 A AR P980101135A AR P980101135 A ARP980101135 A AR P980101135A AR 012293 A1 AR012293 A1 AR 012293A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl group
- group
- asthma
- lower alkyl
- treat
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de piridina representados por la formula (I) y sales farma farmacéuticamente aceptables de los mismos en donde R representa un grupo de laformula: II en donde R1 es un átomo de hidrogeno o un grupo alquilo inferior, R2 es un átomode hidrogeno o un grupo alcoxilo inferior, R3 es un átomo dehidrogeno, un grupo alquilo, un grupo alcanoilo inferior, entre otros, A es un átomo de azufre o átomo de oxigeno además R1 y R2 pueden combinarse el uno conel otro para formar un grupohet erocíclico de 5 0 6 miembros, n es 0 - 2, R4 es un átomo de hidrogeno, un grupo alquilo inferior o un grupo alcoxilo inferior,R8 es un átomo de hidrogeno, un grupo alquilo inferior o un grupo alquilo inferior o un grupo alquilo inferioralcoxil o inferior. Los derivados depirimidina (1) poseen actividad para inhibir la produccion de mediadores tales como citocinas (por ej. IL-4, IL-5 e IL-8 (Interleuquina-4, -5 y -8), TNF-alfa(factor de necrosis de tumor-alfa), LT(leucotrienos),PAF (facto r de activacion de plaquetas), PGs(prostaglandinas), GM-CSF(factor que estimula colonia degranulocito macrofago) y actividad para inhibir 5-lipoxigenasa, así estos derivados son utiles para tratar diversas enfermedades alérgicas,inflamatoriasy cánceres. Además poseen permeabilidad a los vasos sanguíneos de la via aérea, y actividad para inhibir infiltracion celular en el alveolo, particularmenteoptimo para tratar asma bronquial, inhibiendo la respuesta asmática tardía enel asma bronqui al, y enfermedades asmáticas viciosas tales como asma tolerantede droga esteroide, y asma resistente a droga esteroide, y para tratar dermatitis atopica. Los derivados de pirimidina (1) están caracterizados porposeer fuertesactividades para inhibir la formacion de NO, teniendo un tiempo de actividad prolongado, buena propiedad de translocacion en la sangre,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6155097 | 1997-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012293A1 true AR012293A1 (es) | 2000-10-18 |
Family
ID=13174349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101135A AR012293A1 (es) | 1997-03-14 | 1998-03-13 | Derivado de pirimidina y agentes para tratar una enfermedad alergica, asma o dermatitis atopica y para producir inhibicion de no, tnf-alfa, citocinas o5-lipoxigenasa que lo comprenden. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6197774B1 (es) |
| EP (1) | EP1019501A1 (es) |
| KR (1) | KR100382964B1 (es) |
| CN (1) | CN1092659C (es) |
| AR (1) | AR012293A1 (es) |
| AU (1) | AU731838B2 (es) |
| BR (1) | BR9808845A (es) |
| CA (1) | CA2283896A1 (es) |
| HK (1) | HK1025955A1 (es) |
| ID (1) | ID23177A (es) |
| TW (1) | TW495509B (es) |
| WO (1) | WO1998041526A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
| US7868011B2 (en) * | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| US7517887B2 (en) * | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| FR2861992B1 (fr) * | 2003-11-10 | 2007-07-20 | Sanofi Synthelabo | Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide. |
| JP4883996B2 (ja) * | 2005-05-24 | 2012-02-22 | 四国化成工業株式会社 | 水溶性プレフラックス及びその利用 |
| US10953012B2 (en) | 2011-04-26 | 2021-03-23 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of pask |
| US10392389B2 (en) | 2012-10-25 | 2019-08-27 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of PASK |
| WO2014066743A1 (en) | 2012-10-25 | 2014-05-01 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
| CN108658991B (zh) * | 2017-04-01 | 2023-12-15 | 辽宁利锋科技开发有限公司 | 3,5-二取代甲基吡唑并[1,5-a]嘧啶-7-酚盐类似物和衍生物制备方法和用途 |
| PE20210340A1 (es) | 2017-09-15 | 2021-02-22 | Aduro Biotech Inc | Compuestos que contienen pirazolopirimidinona y sus usos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261997A (en) * | 1980-01-11 | 1981-04-14 | Warner-Lambert Company | 4-Alkyl-pyrazolo[5,1-b]-quinazolin-9(4H)-ones and anti-allergic compositions containing them |
| DE3065963D1 (en) | 1979-01-24 | 1984-02-02 | Warner Lambert Co | Pyrazolo (5,1-b) quinazolin-9(4h)-one derivatives, process for their preparation and pharmaceutical compositions containing them |
| CN1030768C (zh) * | 1990-10-09 | 1996-01-24 | 大塚制药株式会社 | 嘧啶衍生物或其药用盐的制备方法 |
| AU667575B2 (en) * | 1992-10-20 | 1996-03-28 | Otsuka Pharmaceutical Co., Ltd. | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor |
| KR100315837B1 (ko) * | 1994-06-21 | 2002-02-28 | 고리 히데아끼 | 피라졸로[1,5-a]피리미딘유도체 |
| EP0795555A4 (en) | 1995-09-28 | 1998-01-07 | Otsuka Pharma Co Ltd | ANALGETICS |
-
1998
- 1998-03-12 ID IDW991009A patent/ID23177A/id unknown
- 1998-03-12 EP EP98907199A patent/EP1019501A1/en not_active Withdrawn
- 1998-03-12 KR KR10-1999-7008259A patent/KR100382964B1/ko not_active IP Right Cessation
- 1998-03-12 US US09/380,742 patent/US6197774B1/en not_active Expired - Fee Related
- 1998-03-12 CN CN98803357A patent/CN1092659C/zh not_active Expired - Fee Related
- 1998-03-12 BR BR9808845-9A patent/BR9808845A/pt not_active IP Right Cessation
- 1998-03-12 CA CA002283896A patent/CA2283896A1/en not_active Abandoned
- 1998-03-12 TW TW087103653A patent/TW495509B/zh not_active IP Right Cessation
- 1998-03-12 WO PCT/JP1998/001042 patent/WO1998041526A1/en not_active Application Discontinuation
- 1998-03-12 AU AU63102/98A patent/AU731838B2/en not_active Ceased
- 1998-03-13 AR ARP980101135A patent/AR012293A1/es unknown
-
2000
- 2000-08-16 HK HK00105098A patent/HK1025955A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW495509B (en) | 2002-07-21 |
| BR9808845A (pt) | 2000-08-01 |
| US6197774B1 (en) | 2001-03-06 |
| KR100382964B1 (ko) | 2003-05-09 |
| ID23177A (id) | 2000-03-23 |
| CA2283896A1 (en) | 1998-09-24 |
| HK1025955A1 (en) | 2000-12-01 |
| KR20000076168A (ko) | 2000-12-26 |
| EP1019501A1 (en) | 2000-07-19 |
| CN1250450A (zh) | 2000-04-12 |
| AU6310298A (en) | 1998-10-12 |
| AU731838B2 (en) | 2001-04-05 |
| CN1092659C (zh) | 2002-10-16 |
| WO1998041526A1 (en) | 1998-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |