AR010808A1 - Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica - Google Patents

Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica

Info

Publication number
AR010808A1
AR010808A1 ARP970105989A ARP970105989A AR010808A1 AR 010808 A1 AR010808 A1 AR 010808A1 AR P970105989 A ARP970105989 A AR P970105989A AR P970105989 A ARP970105989 A AR P970105989A AR 010808 A1 AR010808 A1 AR 010808A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
alkyl
compound
hydrogen
neutrophils
Prior art date
Application number
ARP970105989A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AR010808A1 publication Critical patent/AR010808A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de un compuesto con la formula (I), donde R1 y R2 son, cada uno, independientemente seleccionados del grupo formado por hidrogeno, alquilo de1 a 6 átomos de carbono, benzoilo, formulas (II) o R1 y R2 son grupos de metileno, los cuales se unen para formar un anillo heterocíclico saturado de4-7 miembros; donde cuando R1 o R2 es benzoilo, el anillo de fenilo de la porcion de benzoilo, puede ser opcinalmente mono- o di-sustituida con unsustituyente seleccionado del grupo formado por alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono aciloxi de 2 a 7 átomos de carbono,halogeno, nitro y trifluormetilo; R es hidroxi 4-morfolinilo, 1H-imidazol-1-il, -CH (alcoxi de 1 a 6 átomos de carbono)2, alfa-hidroxibencilo, o fenilo; dondeel anillo de fenilo puede ser opcionalmente sustituido con un sustituyente seleccionado del grupo formado por halogeno y alquilo de 1 a 6 átomos decarbono; R3 es hidrogeno, o alquilo de 1 a 6 átomos de carbono; R4 eshidrogeno, halogeno, alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomosde carbono, o trifluormetilo; R5 es hidrogeno o alquilo de 1 a 6 átomos de carbono; y n = 1-3, o una sal farmacéuticamente aceptable de los mismos, parala fabricacion de un medicamento para tratar o inhibir la neutropenia y/o para acelerar la recuperacion de neutrofilos en un mamífero en necesidad de lamisma, lo cual comprende una cantidad efectiva de dicho compuesto y un vehículo farmacéuticamente aceptable y una composicion farmacéutica.
ARP970105989A 1996-12-19 1997-12-18 Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica AR010808A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77074396A 1996-12-19 1996-12-19

Publications (1)

Publication Number Publication Date
AR010808A1 true AR010808A1 (es) 2000-07-12

Family

ID=25089545

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105989A AR010808A1 (es) 1996-12-19 1997-12-18 Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica

Country Status (7)

Country Link
EP (1) EP0957918A1 (es)
JP (1) JP2001506998A (es)
AR (1) AR010808A1 (es)
AU (1) AU5611398A (es)
CA (1) CA2273288A1 (es)
WO (1) WO1998026781A1 (es)
ZA (1) ZA9711342B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2650962C2 (ru) * 2012-06-07 2018-04-18 Чилдрен'З Хоспитал Лос Анджелес Способы лечения нейтропении с применением ретиноидных агонистов
EP3107533A4 (en) 2014-02-18 2017-10-18 Children's Hospital Los Angeles Compositions and methods for treating neutropenia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2615291B1 (fr) * 1987-05-15 1989-07-13 Thomson Csf Procede de test en fonctionnement d'un dispositif de visualisation d'informations radar et mise en oeuvre de ce procede
EP0329940B1 (en) * 1988-02-22 1994-01-05 American Cyanamid Company 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones
US4916137A (en) * 1988-02-22 1990-04-10 American Cyanamid Company 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders

Also Published As

Publication number Publication date
CA2273288A1 (en) 1998-06-25
WO1998026781A1 (en) 1998-06-25
ZA9711342B (en) 1999-06-17
JP2001506998A (ja) 2001-05-29
EP0957918A1 (en) 1999-11-24
AU5611398A (en) 1998-07-15

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