AR010808A1 - Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica - Google Patents
Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceuticaInfo
- Publication number
- AR010808A1 AR010808A1 ARP970105989A ARP970105989A AR010808A1 AR 010808 A1 AR010808 A1 AR 010808A1 AR P970105989 A ARP970105989 A AR P970105989A AR P970105989 A ARP970105989 A AR P970105989A AR 010808 A1 AR010808 A1 AR 010808A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- alkyl
- compound
- hydrogen
- neutrophils
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Uso de un compuesto con la formula (I), donde R1 y R2 son, cada uno, independientemente seleccionados del grupo formado por hidrogeno, alquilo de1 a 6 átomos de carbono, benzoilo, formulas (II) o R1 y R2 son grupos de metileno, los cuales se unen para formar un anillo heterocíclico saturado de4-7 miembros; donde cuando R1 o R2 es benzoilo, el anillo de fenilo de la porcion de benzoilo, puede ser opcinalmente mono- o di-sustituida con unsustituyente seleccionado del grupo formado por alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomos de carbono aciloxi de 2 a 7 átomos de carbono,halogeno, nitro y trifluormetilo; R es hidroxi 4-morfolinilo, 1H-imidazol-1-il, -CH (alcoxi de 1 a 6 átomos de carbono)2, alfa-hidroxibencilo, o fenilo; dondeel anillo de fenilo puede ser opcionalmente sustituido con un sustituyente seleccionado del grupo formado por halogeno y alquilo de 1 a 6 átomos decarbono; R3 es hidrogeno, o alquilo de 1 a 6 átomos de carbono; R4 eshidrogeno, halogeno, alquilo de 1 a 6 átomos de carbono, alcoxi de 1 a 6 átomosde carbono, o trifluormetilo; R5 es hidrogeno o alquilo de 1 a 6 átomos de carbono; y n = 1-3, o una sal farmacéuticamente aceptable de los mismos, parala fabricacion de un medicamento para tratar o inhibir la neutropenia y/o para acelerar la recuperacion de neutrofilos en un mamífero en necesidad de lamisma, lo cual comprende una cantidad efectiva de dicho compuesto y un vehículo farmacéuticamente aceptable y una composicion farmacéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77074396A | 1996-12-19 | 1996-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR010808A1 true AR010808A1 (es) | 2000-07-12 |
Family
ID=25089545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970105989A AR010808A1 (es) | 1996-12-19 | 1997-12-18 | Uso de un compuesto para la fabricacion de un medicamento util para tratar o inhibir neutropenia y/o para acelerar la recuperacion de neutrofilos y unacomposicion farmaceutica |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0957918A1 (es) |
JP (1) | JP2001506998A (es) |
AR (1) | AR010808A1 (es) |
AU (1) | AU5611398A (es) |
CA (1) | CA2273288A1 (es) |
WO (1) | WO1998026781A1 (es) |
ZA (1) | ZA9711342B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2650962C2 (ru) * | 2012-06-07 | 2018-04-18 | Чилдрен'З Хоспитал Лос Анджелес | Способы лечения нейтропении с применением ретиноидных агонистов |
EP3107533A4 (en) | 2014-02-18 | 2017-10-18 | Children's Hospital Los Angeles | Compositions and methods for treating neutropenia |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2615291B1 (fr) * | 1987-05-15 | 1989-07-13 | Thomson Csf | Procede de test en fonctionnement d'un dispositif de visualisation d'informations radar et mise en oeuvre de ce procede |
EP0329940B1 (en) * | 1988-02-22 | 1994-01-05 | American Cyanamid Company | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones |
US4916137A (en) * | 1988-02-22 | 1990-04-10 | American Cyanamid Company | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders |
-
1997
- 1997-12-17 JP JP52798098A patent/JP2001506998A/ja active Pending
- 1997-12-17 ZA ZA9711342A patent/ZA9711342B/xx unknown
- 1997-12-17 AU AU56113/98A patent/AU5611398A/en not_active Abandoned
- 1997-12-17 CA CA002273288A patent/CA2273288A1/en not_active Abandoned
- 1997-12-17 EP EP97952527A patent/EP0957918A1/en not_active Withdrawn
- 1997-12-17 WO PCT/US1997/023419 patent/WO1998026781A1/en not_active Application Discontinuation
- 1997-12-18 AR ARP970105989A patent/AR010808A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2273288A1 (en) | 1998-06-25 |
WO1998026781A1 (en) | 1998-06-25 |
ZA9711342B (en) | 1999-06-17 |
JP2001506998A (ja) | 2001-05-29 |
EP0957918A1 (en) | 1999-11-24 |
AU5611398A (en) | 1998-07-15 |
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