KR890008063A - 소염제로서 유용한 3급-부틸페닐 화합물 - Google Patents

소염제로서 유용한 3급-부틸페닐 화합물 Download PDF

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KR890008063A
KR890008063A KR1019880015336A KR880015336A KR890008063A KR 890008063 A KR890008063 A KR 890008063A KR 1019880015336 A KR1019880015336 A KR 1019880015336A KR 880015336 A KR880015336 A KR 880015336A KR 890008063 A KR890008063 A KR 890008063A
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에드워즈 루만스 모리스
스트리커 매튜스 랜달
아더 밀러 조셉
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더 프록터 앤드 갬블 캄파니
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Abstract

내용 없음

Description

소염제로서 유용한 3급 - 부틸페닐 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반실(I)의 화합물 및 이의 약학적으로 허용되는 염
    상기식에서, - A1은 -OH, -H 및 -O2CR(여기에서, -R은 탄소수 1 내진 10의 직쇄 또는 측쇄 알킬 그룹이다)로 구성된 그룹에서 선택되고, 바람직하게는 -OH 이며, -A2는 탄소수 1 내지 10의 비치환되거나 치환되고, 포화되거나 불포화된, 직쇄, 측쇄 및 사이클릭 알킬로 구성된 그룹에서 선택되며, 단 C4내지 C10직쇄의 포화된 앞킬 및 3급-부틸은 제외되고, 여기에서 A2의 치환체는 할로, -OR3, -O2CR3, -CO2R3및 -C(O)R3중 하나이상일 수 있으며, 바람직하게는 -A2는 비치환된 C1-C3포화된,직쇄알킬, 비치환된 C2-C6불포화된, 직쇄알킬, 및 비치환된 C3-C6포화되거나 불포화된 측쇄알킬로 구성된 그룹에서 선택되며,-A3는 -C(CH3)3, - Si(CH3)3및 -CF3로 구성된 그룹에서 선택되고, 바람직하게는 -C(CH3)3이며, -Y는 1)-(CR1 2)n-C C-H(여기에서, n은 1내지 6의 정수이다.), 2)--(CR2 2)n-C-H (여기에서, n은 0 내지 5의 정수이다.), 3) -(CR1 2)M--(CR1 2)n-C C-H(여기에서, m은 1 내지 5의 정수이고, m+n은 1 내지 5의 정수이다.), 4)-CR1=CR1--(CR1 2)n-C C-H (여기에서, n은 0 또는 1이다), 5) (CR1 2)n-CR3=CH2(여기에서, n은 2 내지 6의 정수이다.), 6)--(CR1 2)n-CR3=CH2(여기에서, n은 0 내지 5의 정수이다.), 7)-(CR1 2)m--(CR1 2)n-CR3=CH2(여기에서, m은 1 내지 3의 정수이고, m+n은 1 내지 3의 정수이다.), 8)-CR1=CR1--(CR1 2)n-CR3=CH2(여기에서, n은 0 내지 3인 정수이다.), 9)-(CR1 2)n-CR3=C=CH2(여기에서, n은 0 내지 6인 정수이다.), 10)-(CR1 2)m--(CR1 2)n-CR3=C=CH2(여기에서, m+n은 0 내지 5인 정수이다.), 11)-CR1=CR1--(CR1 2)n-CR3=C=CH2(여기에서, n은 0 내지 3인 정수이다.), 12)-(CR1 2)n-CH(ZR4)2(여기에서, n은 1 내지 6인 정수이다), 및 13)-(CR1 2)m--(CR1 2)n-CH(ZR4)2(여기에서, n은 1 내지 5인 정수이고 m은 0 내지 4인 정수이며, m+n은 1 내지 5인 정수이다)로구성된 그룹중에서 선택되며, 각각의 -R1은 -H, -OR1, -NR3 2, -Nr3 3 +, N(R3)C(O)R3, -O2CR3,-CO2R3, C(O)NR3 2, 탄소수 1 내지 3의 직쇄 또는 측쇄의 포화 알킬그룹, 및 탄소수 1 내지 3의 직쇄 또는 측쇄의 불포화 알킬그룹으로 구성된 그룹중에서 독립적으로 선택되거나, 동일 탄소원자상의 두 개의 R1이 = 0 또는 =CR3 2이고 각각의 R2은 -H, -OR3, -NR3 2, -NR3 3 +, NR3 3 +, -N(R3)C(O)R3, O2CR3, -CO2R3, C(O)NR3 2, 탄소수 1 내지 3의 직쇄 또는 측쇄 포화 알킬그룹, 및 탄소수 1 내지2의 직쇄 또는 측쇄 불포화 앞킬그룹으로 구성된 그룹중에서 독립적으로 선택되거나, 동일 탄소원자상의 R2는 =O또는 =CR3 2이며, 각각의 -R3는 -H, 메틸 및 에틸로 구성된 그룹중에서 독립적으로 선택되고, 각각의 -R4는 -CH3및 -CH2CH3로 구성된 그룹중에서 독립적으로 선택되거나, -R4치환체들이 결합하여,-R4치환체들이 함께는 - (CH2)2- 및 -(CH2)3로 구성된 그룹중에서 선택된 하나의 그룹이 되도록 사이클릭 아세탈을 형성할 수 있으며, 각각의 -Z -는 -O-, -S- -NH- 및 -NR4로 구성된 그룹중에서 독립적으로 선택된다
  2. 제 1 항에 있어서,- R1및 R2가 각각 독립적으로 -H, -OH, 메틸, 또는 에틸로 구성된 그룹중에서 선택되거나, 동일 탄소원자상의 두 개의 -R1또는 -R2가 =O 또는 CH2이고, 여기에서 약 2개 이하의 -R1또는 -R2그룹이 -H가 아니며 바람직하게는 각각의 R1및 -R2가 -H 이고 : -R3는 각각 -H 이고 : -R4는 각각 메틸이거나, -R4그룹들이 함께는 사이클릭 아세탈을 형성하는 그룹 -(CH2)2이며 : -Z-는 가기 독립적으로 -0- 및 -S-로 구성된 그룹중에서 선택되고, 바람직하게는 -0-임을 특징으로 하는 화합물
  3. 제 1 항 또는 2항에 있어서, -Y그룹이, 1) -(CR1 2)2--(CR1 2)n-C CH(여기에서, n은 1내지 6인 정수이다), 2) --(CR2 2)n-C CH(여기에서, n은 0 내지 5인 정수이다.), 3) -(CR1 2)2--(CR1 2)n-C CH(여기에서, n은 0 내지 3인 정수이다), 4) -CR1=CR1--(CR1 2)n-C CH(여기에서, n은 0 또는 1이다.). 5) -(CR2 2)n-CH(ZR4)2(여기에서, n은 1 내지 6인 정수이다.), 6) --(CR1 2)n-CH(ZR4)2(여기에서, n은 1 내지 5인 정수이다.) 및 7) -(CR1 2)2--(CR1 2)n-C-CH(ZR4)2(여기에서, n은 1 내지 3인 정수이다)로 구성된 그룹중에서 선택되는 화합물.
  4. 제1항 또는 제2항에 있어서, -Y그룹이 1) -(CR1 2)2--(CR1 2)n-C CH(여기에서, n은 0 내지 3인 정수이다.), 2) --(CR2 2)n-CH(ZR4)2(여기에서, n은 1 내지 5인 정수이다.), 및 3) --(CR2 2)n-C CH(여기에서, n은 0 내지 5인 정수이다.)로 구성된 그룹중에서 선택되는 화합물.
  5. 제 1 항 또는 2항에 있어서, -Y그룹이 --(CR2 2)n-C (여기에서, n은 0 내지 5인 정수이며, 바람직하게는 3이다)인 화합물
  6. 안전 및 유효량의 제 1 항 내지 5항 중 어느 한 항에 따른 소엽성 화합물 및 약학적으로 허용되는 담체를 함유함을 특징으로 하는 약학적 조성물
  7. 염증을 치료하기 위한 약제의 제조를 위한 제 1 내지 5항 중 어느 한 항에 따른 화합물의 용도
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880015336A 1987-11-23 1988-11-22 소염제로서 유용한 3급-부틸페닐 화합물 KR890008063A (ko)

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US07/123,694 US4847303A (en) 1987-11-23 1987-11-23 Tert-butylphenyl compounds useful as anti-inflammatory agents

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JPH0623194B2 (ja) * 1985-03-23 1994-03-30 鐘淵化学工業株式会社 新規ラクタム誘導体及び抗炎症剤
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IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
JPH0654315A (ja) * 1992-07-31 1994-02-25 Canon Inc 動画像符号化方法及び装置

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DK652988D0 (da) 1988-11-23
PH25570A (en) 1991-08-08
US4847303B1 (ko) 1991-03-12
EP0318090A2 (en) 1989-05-31
ZA888726B (en) 1989-08-30
US4847303A (en) 1989-07-11
JPH02122A (ja) 1990-01-05
DK652988A (da) 1989-05-24
IL88366A0 (en) 1989-06-30
AU2577088A (en) 1989-05-25
EP0318090A3 (en) 1990-05-16

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