AR009092A1 - Un procedimiento para preparar 2'-fluoro-5-metil-beta-l- arabinofuranosiluridina. - Google Patents

Un procedimiento para preparar 2'-fluoro-5-metil-beta-l- arabinofuranosiluridina.

Info

Publication number
AR009092A1
AR009092A1 ARP970104409A ARP970104409A AR009092A1 AR 009092 A1 AR009092 A1 AR 009092A1 AR P970104409 A ARP970104409 A AR P970104409A AR P970104409 A ARP970104409 A AR P970104409A AR 009092 A1 AR009092 A1 AR 009092A1
Authority
AR
Argentina
Prior art keywords
arabinofuranosiluridine
preparing
procedure
fluoro
beta
Prior art date
Application number
ARP970104409A
Other languages
English (en)
Spanish (es)
Original Assignee
Univ Georgia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia filed Critical Univ Georgia
Publication of AR009092A1 publication Critical patent/AR009092A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ARP970104409A 1997-07-23 1997-09-25 Un procedimiento para preparar 2'-fluoro-5-metil-beta-l- arabinofuranosiluridina. AR009092A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5348897P 1997-07-23 1997-07-23

Publications (1)

Publication Number Publication Date
AR009092A1 true AR009092A1 (es) 2000-03-08

Family

ID=21984622

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104409A AR009092A1 (es) 1997-07-23 1997-09-25 Un procedimiento para preparar 2'-fluoro-5-metil-beta-l- arabinofuranosiluridina.

Country Status (21)

Country Link
US (2) US6512107B2 (OSRAM)
EP (2) EP0998482B1 (OSRAM)
KR (1) KR100247505B1 (OSRAM)
CN (1) CN1113892C (OSRAM)
AR (1) AR009092A1 (OSRAM)
AT (2) ATE304547T1 (OSRAM)
AU (1) AU8758298A (OSRAM)
BR (1) BR9810804B1 (OSRAM)
DE (2) DE69831619T2 (OSRAM)
DK (1) DK1327637T3 (OSRAM)
ES (2) ES2249678T3 (OSRAM)
ID (1) ID20624A (OSRAM)
IL (1) IL121730A (OSRAM)
IN (1) IN186807B (OSRAM)
MY (1) MY117314A (OSRAM)
PT (2) PT1327637E (OSRAM)
SA (1) SA98180771B1 (OSRAM)
SI (1) SI1327637T1 (OSRAM)
TR (1) TR199701051A2 (OSRAM)
TW (1) TW434252B (OSRAM)
WO (2) WO1999005157A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW434252B (en) 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
KR100449618B1 (ko) * 1998-03-27 2004-11-16 부광약품 주식회사 2'-플루오로-5-메틸-β-L-아라비노푸라노실유리딘의 제조방법
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
DE60204859T2 (de) * 2001-03-30 2006-04-27 Gilead Sciences, Inc., Foster City Verfahren zur Herstellung von 2'-Halo-beta-L-arabino-furanosylnucleosiden
KR100487992B1 (ko) * 2001-10-25 2005-05-09 부광약품 주식회사 2'-플루오로-5-메틸-β-엘-아라비노푸라노실유리딘의 황유도체
US7211570B2 (en) * 2001-12-20 2007-05-01 Pharmasset, Inc. Treatment of EBV and KHSV infection
KR100976778B1 (ko) 2003-04-17 2010-08-18 부광약품 주식회사 1-（2'-플루오로-베타-엘-아라비노푸라노실）티민의 황 유도체를 유효 활성 성분으로 하는 b형 간염 바이러스 치료제
SG158136A1 (en) 2004-09-14 2010-01-29 Pharmasset Inc Preparation of 2`-fluoro-2`- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
MX2007015534A (es) 2005-06-07 2008-02-25 Univ Yale Metodos para tratar el cancer y otras condiciones o estados de enfermedad utilizando la 2'-fluoro-5-metil-beta-l-arabinofuranosiluridina y la beta -l-2'-d soxirribofuranosiltimidina.
CN101328171A (zh) 2007-06-18 2008-12-24 张中能 一种溴苯基-取代的噻唑二氢嘧啶
GB0907551D0 (en) 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
US11760773B2 (en) 2018-02-02 2023-09-19 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate
CN109320564B (zh) * 2018-10-26 2022-05-31 浙江晟格生物科技有限公司 一种l-来苏糖的制备工艺
CN109467541A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种绿色合成克拉夫定药物中间体的方法
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3714473A1 (de) * 1987-04-30 1988-11-10 Basf Ag Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose
JP2784230B2 (ja) 1988-02-09 1998-08-06 ユーオーピー・インコーポレーテッド エピマーアルドースおよびアルドース同族体の連続相互変換に用いる固体触媒
DE4002727A1 (de) * 1990-01-31 1991-08-01 Bayer Ag Mischungen aus waessrigen polymerdispersionen
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine

Also Published As

Publication number Publication date
AU8758298A (en) 1999-02-16
DE69831619D1 (de) 2005-10-20
PT998482E (pt) 2003-08-29
IL121730A0 (en) 1998-02-22
DK1327637T3 (da) 2006-01-16
MY117314A (en) 2004-06-30
TR199701051A3 (tr) 1999-03-22
IL121730A (en) 2005-03-20
WO1999005158A1 (en) 1999-02-04
CN1206012A (zh) 1999-01-27
SA98180771B1 (ar) 2006-10-29
US6894159B2 (en) 2005-05-17
DE69812959T2 (de) 2004-03-04
EP0998482A1 (en) 2000-05-10
BR9810804B1 (pt) 2012-01-10
ATE304547T1 (de) 2005-09-15
ID20624A (id) 1999-01-28
PT1327637E (pt) 2005-11-30
IN186807B (OSRAM) 2001-11-10
CN1113892C (zh) 2003-07-09
DE69831619T2 (de) 2006-06-14
BR9810804A (pt) 2000-09-12
DE69812959D1 (de) 2003-05-08
ES2195370T3 (es) 2003-12-01
EP1327637A1 (en) 2003-07-16
US20020062018A1 (en) 2002-05-23
US6512107B2 (en) 2003-01-28
EP1327637B1 (en) 2005-09-14
EP0998482B1 (en) 2003-04-02
TW434252B (en) 2001-05-16
KR100247505B1 (ko) 2000-03-15
KR19990013297A (ko) 1999-02-25
TR199701051A2 (xx) 1999-03-22
WO1999005157A1 (en) 1999-02-04
ATE236187T1 (de) 2003-04-15
US20030139593A1 (en) 2003-07-24
ES2249678T3 (es) 2006-04-01
SI1327637T1 (sl) 2005-12-31

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