AR008006A1 - Inhibidores de cox-2 de piranoindol y carbazol, procedimientos para su preparacion, uso de los mismos para preparar medicamentos y composicionesfarmaceuticas que los contienen. - Google Patents

Inhibidores de cox-2 de piranoindol y carbazol, procedimientos para su preparacion, uso de los mismos para preparar medicamentos y composicionesfarmaceuticas que los contienen.

Info

Publication number
AR008006A1
AR008006A1 ARP970103390A ARP970103390A AR008006A1 AR 008006 A1 AR008006 A1 AR 008006A1 AR P970103390 A ARP970103390 A AR P970103390A AR P970103390 A ARP970103390 A AR P970103390A AR 008006 A1 AR008006 A1 AR 008006A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
alkyl
cox
inhibitors
pharmaceutical compositions
Prior art date
Application number
ARP970103390A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR008006A1 publication Critical patent/AR008006A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Inhibidores de cox-2 de piranoindol y carbazol de la fórmula (I), en la cual cada uno de R1, R2, R3 y R4 es independientemente hidrógeno alquilo de1 a 6 átomos de carbono, alquenilo de 2 a 7 átomos, alquinilo de 2 a 7 átomos de carbono, alcoxide 1 a 6 átomos de carbono, aralcoxi de 7 a 12 átomosde carbono, trifluoroalcoxi, alcanoiloxi de 2 a 6 átomos de carbono, hidroxi, halo, trifluorometilo, ciano, amino, mono- o di-alquilamino enel cual cada grupo alquilo tiene de 1 a 6 átomos de carbono, alcanamido de 2 a 6 átomos de carbono, o alcansulfonamido de 1 a 6 carbono; R5 eshidrógeno, alquilo de 1 a 6 átomos de carbono, alquenilo de 2 a 7 átomos de carbono alcoxialquilo en el cual cada porción alquilo tiene de1 a 6átomos de carbono o alquilcicloalquilo en el cual la porción alquilo tiene de 1 a 6 átomos de carbono y la porción cicloalquilo tiene de 3 a 8 átomosde carbono; R6 es hidrógeno, alquilo de 1 a 6 átomos de carbono o alquenilo de 2 a 7 átomos de carbono; X es oxígeno o metileno; A es NZ; Z esoxhidrilo, alcoxi, ariloxi, carboxialquiloxi de 2 a 7 átomos de carbono. arilamino, o alquilsulfonilamino de 1 a 6 átomos de carbono, o una salfarmacéuticamente aceptable del mismo que sonde utilidad en el tratamiento de las afecciones artríticas, el cáncer colorrectal y la enfermedadde Alzheimer, procedimiento para su preparación, uso de dichos compuestos para preparar medicamentos y composiciones farmacéuticasque los contienen.
ARP970103390A 1996-07-26 1997-07-25 Inhibidores de cox-2 de piranoindol y carbazol, procedimientos para su preparacion, uso de los mismos para preparar medicamentos y composicionesfarmaceuticas que los contienen. AR008006A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68784996A 1996-07-26 1996-07-26

Publications (1)

Publication Number Publication Date
AR008006A1 true AR008006A1 (es) 1999-11-24

Family

ID=24762121

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103390A AR008006A1 (es) 1996-07-26 1997-07-25 Inhibidores de cox-2 de piranoindol y carbazol, procedimientos para su preparacion, uso de los mismos para preparar medicamentos y composicionesfarmaceuticas que los contienen.

Country Status (13)

Country Link
EP (1) EP0923552A1 (es)
JP (1) JP2000515887A (es)
KR (1) KR20000029545A (es)
CN (1) CN1230948A (es)
AR (1) AR008006A1 (es)
AU (1) AU4043397A (es)
BR (1) BR9710597A (es)
CA (1) CA2261588A1 (es)
HU (1) HUP9904054A2 (es)
IL (1) IL128031A0 (es)
NZ (1) NZ334320A (es)
WO (1) WO1998004527A1 (es)
ZA (1) ZA976611B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1104297B8 (en) * 1998-07-09 2006-05-03 Cephalon, Inc. Compositions for the treatment of chronic lymphocytic leukemia
PL1534305T3 (pl) 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
GB0522908D0 (en) * 2005-11-10 2005-12-21 Merck Sharp & Dohme Therapeutic agents
US20140249193A1 (en) * 2011-04-12 2014-09-04 The Regents Of The University Of California Modulators of mitochondrial protein import
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686213A (en) * 1986-08-15 1987-08-11 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
US4927842A (en) * 1989-09-29 1990-05-22 American Home Products Corporation 2,3,4,9-tetrahydro-1H-carbazole acetic acid derivatives, composition and use as anti-inflammatories

Also Published As

Publication number Publication date
CA2261588A1 (en) 1998-02-05
BR9710597A (pt) 1999-08-17
ZA976611B (en) 1999-01-25
KR20000029545A (ko) 2000-05-25
EP0923552A1 (en) 1999-06-23
IL128031A0 (en) 1999-11-30
CN1230948A (zh) 1999-10-06
JP2000515887A (ja) 2000-11-28
HUP9904054A2 (hu) 2000-04-28
WO1998004527A1 (en) 1998-02-05
NZ334320A (en) 1999-10-28
AU4043397A (en) 1998-02-20

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