HUP9904054A2 - COX-2 piranoindol és karbazol inhibitorai - Google Patents
COX-2 piranoindol és karbazol inhibitoraiInfo
- Publication number
- HUP9904054A2 HUP9904054A2 HU9904054A HUP9904054A HUP9904054A2 HU P9904054 A2 HUP9904054 A2 HU P9904054A2 HU 9904054 A HU9904054 A HU 9904054A HU P9904054 A HUP9904054 A HU P9904054A HU P9904054 A2 HUP9904054 A2 HU P9904054A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- amino
- atom
- alkyloxy
- amido
- Prior art date
Links
- UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 title 2
- 101150071146 COX2 gene Proteins 0.000 title 1
- 101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 title 1
- 101150000187 PTGS2 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- ABPJREHLAYHTHW-UHFFFAOYSA-N pyrano[2,3-g]indole Chemical compound O1C=CC=C2C3=NC=CC3=CC=C21 ABPJREHLAYHTHW-UHFFFAOYSA-N 0.000 title 1
- -1 trifluoroalkyloxy Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000015634 Rectal Neoplasms Diseases 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000004946 alkenylalkyl group Chemical group 0.000 abstract 1
- 125000006466 alkoxy alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 206010038038 rectal cancer Diseases 0.000 abstract 1
- 201000001275 rectum cancer Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A jelen találmány tárgya (I) általánős képletű vegyületek, ahől R1, R2, R3 és R4 egymástól függetlenül jelentenek hidrőgénatőmőt,alkil-, akenil-, alkinil-, alkőxi-, aralkőxi-, triflűőr-alkőxi-,alkanőil-őxi-, hidrőxilcsőpőrtőt, halőgénatőmőt, triflűőr-metil-,cianő-, aminő-, mőnő- vagy dialkil-aminő-, alkán-amidő- vagy alkán-szűlfőn-amidő-csőpőrtőt, R5 jelentése hidrőgénatőm, alkil-, alkenil-, alkőxi-alkil- vagy alkil-ciklőalkil-csőpőrt, R6 jelentése hidrőgénatőm, alkil- vagy alkinilcsőpőrt, X jelentése őxigénatőm vagy metiléncsőpőrt, A jelentése őxigénatőm vagy NZ, Z jelentése hidrőxil-, alkőxi-, arilőxi-, 2-7 szénatőmős karbőxi-alkőxi-, aril-aminő- vagy 1-6 szénatőmős alkil-szűlfőnil-aminő-csőpőrt, vagy gyógyászatilag elfőgadható sóik. A vegyületeketartritiszes betegségek és kilőrektális rák, valamint Alzheimer-kórkezelésére lehet alkalmazni. (I) ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68784996A | 1996-07-26 | 1996-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP9904054A2 true HUP9904054A2 (hu) | 2000-04-28 |
Family
ID=24762121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904054A HUP9904054A2 (hu) | 1996-07-26 | 1997-07-22 | COX-2 piranoindol és karbazol inhibitorai |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0923552A1 (hu) |
| JP (1) | JP2000515887A (hu) |
| KR (1) | KR20000029545A (hu) |
| CN (1) | CN1230948A (hu) |
| AR (1) | AR008006A1 (hu) |
| AU (1) | AU4043397A (hu) |
| BR (1) | BR9710597A (hu) |
| CA (1) | CA2261588A1 (hu) |
| HU (1) | HUP9904054A2 (hu) |
| IL (1) | IL128031A0 (hu) |
| NZ (1) | NZ334320A (hu) |
| WO (1) | WO1998004527A1 (hu) |
| ZA (1) | ZA976611B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ509376A (en) * | 1998-07-09 | 2003-10-31 | Francis A Nardella | Indole or carbazole derivatives for the treatment of chronic lyphocytic leukemia |
| DE602004002832T2 (de) | 2003-05-07 | 2007-06-06 | Osteologix A/S | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
| GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
| GB0522908D0 (en) | 2005-11-10 | 2005-12-21 | Merck Sharp & Dohme | Therapeutic agents |
| US20140249193A1 (en) * | 2011-04-12 | 2014-09-04 | The Regents Of The University Of California | Modulators of mitochondrial protein import |
| CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4686213A (en) * | 1986-08-15 | 1987-08-11 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids |
| US4927842A (en) * | 1989-09-29 | 1990-05-22 | American Home Products Corporation | 2,3,4,9-tetrahydro-1H-carbazole acetic acid derivatives, composition and use as anti-inflammatories |
-
1997
- 1997-07-22 WO PCT/US1997/012782 patent/WO1998004527A1/en not_active Application Discontinuation
- 1997-07-22 CA CA002261588A patent/CA2261588A1/en not_active Abandoned
- 1997-07-22 BR BR9710597A patent/BR9710597A/pt not_active Application Discontinuation
- 1997-07-22 JP JP10508916A patent/JP2000515887A/ja active Pending
- 1997-07-22 HU HU9904054A patent/HUP9904054A2/hu unknown
- 1997-07-22 IL IL12803197A patent/IL128031A0/xx unknown
- 1997-07-22 AU AU40433/97A patent/AU4043397A/en not_active Abandoned
- 1997-07-22 CN CN97197994A patent/CN1230948A/zh active Pending
- 1997-07-22 NZ NZ334320A patent/NZ334320A/en unknown
- 1997-07-22 EP EP97938009A patent/EP0923552A1/en not_active Withdrawn
- 1997-07-22 KR KR1019997000603A patent/KR20000029545A/ko not_active Application Discontinuation
- 1997-07-24 ZA ZA976611A patent/ZA976611B/xx unknown
- 1997-07-25 AR ARP970103390A patent/AR008006A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1230948A (zh) | 1999-10-06 |
| AR008006A1 (es) | 1999-11-24 |
| EP0923552A1 (en) | 1999-06-23 |
| IL128031A0 (en) | 1999-11-30 |
| KR20000029545A (ko) | 2000-05-25 |
| NZ334320A (en) | 1999-10-28 |
| BR9710597A (pt) | 1999-08-17 |
| AU4043397A (en) | 1998-02-20 |
| ZA976611B (en) | 1999-01-25 |
| CA2261588A1 (en) | 1998-02-05 |
| WO1998004527A1 (en) | 1998-02-05 |
| JP2000515887A (ja) | 2000-11-28 |
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