AR006616A1 - Derivados carboxilicos utiles como inhibidores de los receptores de las endotelinas y composiciones farmaceuticas que los contienen - Google Patents
Derivados carboxilicos utiles como inhibidores de los receptores de las endotelinas y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR006616A1 AR006616A1 ARP970101461A ARP970101461A AR006616A1 AR 006616 A1 AR006616 A1 AR 006616A1 AR P970101461 A ARP970101461 A AR P970101461A AR P970101461 A ARP970101461 A AR P970101461A AR 006616 A1 AR006616 A1 AR 006616A1
- Authority
- AR
- Argentina
- Prior art keywords
- inhibitors
- receptors
- endothelins
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a derivados de carboxílicos de la fórmula (I) donde los restos poseen el significado definido en la descripción, a la preparaciónde estos compuestos y a su aplicación como medicamentos. Dichos derivados son útiles comoinhib idores de receptores de la endotelina, de reducida uniónendoplamática.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19614534A DE19614534A1 (de) | 1996-04-12 | 1996-04-12 | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
AR006616A1 true AR006616A1 (es) | 1999-09-08 |
Family
ID=7791118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970101461A AR006616A1 (es) | 1996-04-12 | 1997-04-11 | Derivados carboxilicos utiles como inhibidores de los receptores de las endotelinas y composiciones farmaceuticas que los contienen |
Country Status (26)
Country | Link |
---|---|
US (1) | US6610691B1 (es) |
EP (1) | EP0892786B1 (es) |
JP (1) | JP2000508324A (es) |
KR (1) | KR20000005367A (es) |
CN (1) | CN1216041A (es) |
AR (1) | AR006616A1 (es) |
AT (1) | ATE268760T1 (es) |
AU (1) | AU714717B2 (es) |
BG (1) | BG63201B1 (es) |
BR (1) | BR9708609A (es) |
CA (1) | CA2251381A1 (es) |
CO (1) | CO4900039A1 (es) |
CZ (1) | CZ324798A3 (es) |
DE (2) | DE19614534A1 (es) |
HR (1) | HRP970199A2 (es) |
HU (1) | HUP9901315A3 (es) |
ID (1) | ID16824A (es) |
IL (1) | IL126027A0 (es) |
NO (1) | NO311571B1 (es) |
NZ (1) | NZ331735A (es) |
PL (1) | PL329238A1 (es) |
SK (1) | SK133998A3 (es) |
TR (1) | TR199802044T2 (es) |
TW (1) | TW426672B (es) |
WO (1) | WO1997038980A1 (es) |
ZA (1) | ZA973098B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2275256A1 (en) * | 1996-12-18 | 1998-06-25 | Basf Aktiengesellschaft | Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists |
US6030975A (en) * | 1997-03-14 | 2000-02-29 | Basf Aktiengesellschaft | Carboxylic acid derivatives, their preparation and use in treating cancer |
ID24278A (id) * | 1997-10-31 | 2000-07-13 | Basf Ag | Turunan-turunan asam karboksilat baru dengan rantai sisi amida, pembuatan dan penggunaannya sebagai reseptor antagonis endotelin |
DE19806438A1 (de) * | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
DE10025728A1 (de) * | 2000-05-25 | 2001-11-29 | Basf Ag | Neue Carbamate und Harnstoffe, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten |
WO2002064573A1 (de) * | 2001-02-14 | 2002-08-22 | Abbott Gmbh & Co. Kg | Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten |
DE60120104T2 (de) | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
PT1243263E (pt) | 2001-03-21 | 2003-03-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe peptidica de composto para o tratamento de alodinia ou de outros tipos diferentes de dor cronica ou fantasma |
US8008351B2 (en) | 2004-04-16 | 2011-08-30 | Ucb Pharma Gmbh | Methods for prophylaxis or treatment of conditions associated with cortical spreading depression |
EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
EP1781276B1 (en) | 2004-08-27 | 2010-06-23 | UCB Pharma GmbH | Use of peptide compounds for treating bone cancer pain, chemotherapy- and nucleoside-induced pain |
EP1910272A4 (en) | 2005-07-22 | 2010-08-04 | Merck Frosst Canada Ltd | INHIBITORS OF THE RENINE |
EA027836B1 (ru) | 2006-06-15 | 2017-09-29 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая комбинация для профилактики, облегчения и/или лечения приступов эпилепсии и ее применение |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2053603A1 (en) * | 1990-10-19 | 1992-04-20 | Katsumasa Harada | 3-alkoxyalkanoic acid derivative, process for preparing the same and herbicide using the same |
DE4313412A1 (de) | 1993-04-23 | 1994-10-27 | Basf Ag | 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung |
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
-
1996
- 1996-04-12 DE DE19614534A patent/DE19614534A1/de not_active Withdrawn
-
1997
- 1997-04-04 NZ NZ331735A patent/NZ331735A/en unknown
- 1997-04-04 KR KR1019980708089A patent/KR20000005367A/ko not_active Application Discontinuation
- 1997-04-04 EP EP97915481A patent/EP0892786B1/de not_active Expired - Lifetime
- 1997-04-04 CN CN97193749A patent/CN1216041A/zh active Pending
- 1997-04-04 TR TR1998/02044T patent/TR199802044T2/xx unknown
- 1997-04-04 CA CA002251381A patent/CA2251381A1/en not_active Abandoned
- 1997-04-04 JP JP9536697A patent/JP2000508324A/ja active Pending
- 1997-04-04 DE DE59711704T patent/DE59711704D1/de not_active Expired - Fee Related
- 1997-04-04 IL IL12602797A patent/IL126027A0/xx unknown
- 1997-04-04 PL PL97329238A patent/PL329238A1/xx unknown
- 1997-04-04 US US09/155,946 patent/US6610691B1/en not_active Expired - Fee Related
- 1997-04-04 BR BR9708609A patent/BR9708609A/pt not_active IP Right Cessation
- 1997-04-04 SK SK1339-98A patent/SK133998A3/sk unknown
- 1997-04-04 WO PCT/EP1997/001684 patent/WO1997038980A1/de not_active Application Discontinuation
- 1997-04-04 CZ CZ983247A patent/CZ324798A3/cs unknown
- 1997-04-04 AT AT97915481T patent/ATE268760T1/de not_active IP Right Cessation
- 1997-04-04 HU HU9901315A patent/HUP9901315A3/hu unknown
- 1997-04-04 AU AU22940/97A patent/AU714717B2/en not_active Ceased
- 1997-04-11 ZA ZA973098A patent/ZA973098B/xx unknown
- 1997-04-11 HR HR19614534.1A patent/HRP970199A2/xx not_active Application Discontinuation
- 1997-04-11 AR ARP970101461A patent/AR006616A1/es unknown
- 1997-04-11 TW TW086104677A patent/TW426672B/zh not_active IP Right Cessation
- 1997-04-11 CO CO97018893A patent/CO4900039A1/es unknown
- 1997-04-14 ID IDP971241A patent/ID16824A/id unknown
-
1998
- 1998-10-05 BG BG102814A patent/BG63201B1/bg unknown
- 1998-10-09 NO NO19984714A patent/NO311571B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR9708609A (pt) | 1999-08-03 |
NO984714L (no) | 1998-10-09 |
HUP9901315A2 (hu) | 1999-08-30 |
SK133998A3 (en) | 1999-03-12 |
BG102814A (en) | 1999-11-30 |
EP0892786A1 (de) | 1999-01-27 |
WO1997038980A1 (de) | 1997-10-23 |
NO311571B1 (no) | 2001-12-10 |
PL329238A1 (en) | 1999-03-15 |
KR20000005367A (ko) | 2000-01-25 |
ZA973098B (en) | 1998-10-12 |
EP0892786B1 (de) | 2004-06-09 |
BG63201B1 (bg) | 2001-06-29 |
US6610691B1 (en) | 2003-08-26 |
CZ324798A3 (cs) | 1999-04-14 |
TR199802044T2 (xx) | 1999-02-22 |
IL126027A0 (en) | 1999-05-09 |
ATE268760T1 (de) | 2004-06-15 |
NZ331735A (en) | 2000-06-23 |
AU2294097A (en) | 1997-11-07 |
NO984714D0 (no) | 1998-10-09 |
AU714717B2 (en) | 2000-01-06 |
CO4900039A1 (es) | 2000-03-27 |
DE19614534A1 (de) | 1997-10-16 |
CA2251381A1 (en) | 1997-10-23 |
HRP970199A2 (en) | 1998-06-30 |
JP2000508324A (ja) | 2000-07-04 |
TW426672B (en) | 2001-03-21 |
ID16824A (id) | 1997-11-13 |
DE59711704D1 (de) | 2004-07-15 |
CN1216041A (zh) | 1999-05-05 |
HUP9901315A3 (en) | 2000-03-28 |
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Legal Events
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FB | Suspension of granting procedure |