AR006318A1 - Piridinas sustituidas por 2-arilo, procedimientos para su preparacion, composiciones farmaceuticas que las contienen y su uso en la preparacion dedichas composiciones farmaceuticas. - Google Patents
Piridinas sustituidas por 2-arilo, procedimientos para su preparacion, composiciones farmaceuticas que las contienen y su uso en la preparacion dedichas composiciones farmaceuticas.Info
- Publication number
- AR006318A1 AR006318A1 ARP970101096A ARP970101096A AR006318A1 AR 006318 A1 AR006318 A1 AR 006318A1 AR P970101096 A ARP970101096 A AR P970101096A AR P970101096 A ARP970101096 A AR P970101096A AR 006318 A1 AR006318 A1 AR 006318A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- substituted
- branched alkyl
- same
- aryl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Piridinas sustituidas por 2-arilo, que comprenden la fórmula general (I) en la cual A y E son iguales o distintos y son arilo con 6 a 10 átomos decarbono que, dado el caso, están hasta trisustituidos por sustituyentes iguales o distintos,halógeno, hidroxilo, trifluormetilo, trifluormetoxi, opor alquilo, acilo, hidroxialquilo o alcoxi lineales o ramificados con hasta 7 átomos de carbono respectivamente, o por un grupo de fórmula: -NR1R2, en lacual R1 y R2 son iguales o distintos yson hidrógeno, fenilo o alquilo lineal o ramificado con hasta 6 átomos de carbono; D es alquilo lineal o ramificadocon hasta 8 átomos de carbono que está sustituido por hidroxilo, L es cicloalquilo con 3 a 8 átomos de carbono o alquilo lineal o ramificado conhasta 8 átomos de carbono que, dado el caso, está sustituido por cicloalquilo con 3 a 8 átomos de carbono o por hidroxilo; T es un resto defórmula (II), donde R3 y R4 son iguales o distintos y son cicloalquilo con3 a 8 átomos de carbono, o son arilo con 6 a 10 átomos de carbono o un heterocicloaromático de 5 a 7 eslabones, dado el caso benzocondensado, con hasta 3 heteroátomos del grupo S, N y/u O que, dado el caso, están hastatrisustituidos por sustituyentes iguales o distintos trifluormetilo, trifluormetoxi, halógeno, hidroxilo, carboxilo, nitro, por alquilo, acilo,alcoxi o alcoxicarbonilo lineales o ramificados con hasta 6 átomos de carbono respectivamente o por fenilo, fenoxi ofeniltio que, por su parte, puedenestar sustituidos por halógeno, trifluormetilo o trifluormetoxi, y/o los ciclos están sustituidos, dado el caso, por un grupo de fórmula: -NR7R8, enla cual: R7 y R8 son iguales o distintos y tienen el significado indicado más arriba para R1 y R2; X significa alquilo o alquenilo lineal o ramificado
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19610932A DE19610932A1 (de) | 1996-03-20 | 1996-03-20 | 2-Aryl-substituierte Pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006318A1 true AR006318A1 (es) | 1999-08-25 |
Family
ID=7788843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101096A AR006318A1 (es) | 1996-03-20 | 1997-03-19 | Piridinas sustituidas por 2-arilo, procedimientos para su preparacion, composiciones farmaceuticas que las contienen y su uso en la preparacion dedichas composiciones farmaceuticas. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US5925645A (es) |
| EP (1) | EP0796846B1 (es) |
| JP (1) | JPH09255574A (es) |
| AR (1) | AR006318A1 (es) |
| AT (1) | ATE194832T1 (es) |
| AU (1) | AU1628097A (es) |
| BG (1) | BG101339A (es) |
| BR (1) | BR9701348A (es) |
| CA (1) | CA2200175A1 (es) |
| CO (1) | CO4520282A1 (es) |
| CZ (1) | CZ84397A3 (es) |
| DE (2) | DE19610932A1 (es) |
| DK (1) | DK0796846T3 (es) |
| EE (1) | EE9700060A (es) |
| ES (1) | ES2150157T3 (es) |
| GR (1) | GR3034546T3 (es) |
| HR (1) | HRP970105A2 (es) |
| HU (1) | HUP9700610A1 (es) |
| ID (1) | ID16292A (es) |
| IL (1) | IL120468A0 (es) |
| MY (1) | MY132490A (es) |
| NO (1) | NO971269L (es) |
| NZ (1) | NZ314419A (es) |
| PL (1) | PL319050A1 (es) |
| PT (1) | PT796846E (es) |
| SG (1) | SG50805A1 (es) |
| SK (1) | SK36197A3 (es) |
| TN (1) | TNSN97048A1 (es) |
| TR (1) | TR199700213A2 (es) |
| ZA (1) | ZA972375B (es) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| AR008789A1 (es) * | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
| JP2894445B2 (ja) * | 1997-02-12 | 1999-05-24 | 日本たばこ産業株式会社 | Ｃｅｔｐ活性阻害剤として有効な化合物 |
| DE19709125A1 (de) * | 1997-03-06 | 1998-09-10 | Bayer Ag | Substituierte Chinoline |
| WO1999041237A1 (en) * | 1998-02-13 | 1999-08-19 | G.D. Searle & Co. | Substituted pyridines useful for inhibiting cholesteryl ester transfer protein activity |
| JP4546589B2 (ja) * | 1998-04-23 | 2010-09-15 | 武田薬品工業株式会社 | ナフタレン誘導体 |
| CA2345103C (en) * | 1998-09-25 | 2011-04-26 | Monsanto Company | (r)-chiral halogenated 1-substitutedamino-(n+1)-alkanols useful for inhibiting cholesteryl ester transfer protein activity |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| DE69907960T2 (de) | 1998-12-23 | 2004-02-26 | G.D. Searle Llc, Chicago | Kombinationen von ileumgallensäuretransports inhibitoren und fibronsäure derivaten für kardiovaskuläre indikationen |
| US6569905B1 (en) | 1998-12-23 | 2003-05-27 | G.D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| EA009466B1 (ru) | 1998-12-23 | 2007-12-28 | Джи.Ди. Сирл Ллс | Ингибитор белка, переносящего эфир холестерила |
| ES2200587T3 (es) | 1998-12-23 | 2004-03-01 | G.D. Searle Llc | Combinaciones de inhibidors del transporte de acidos biliares del ileon e inhibidores de la proteina de transferencia de colesteril ester para indicaciones cardiovasculares. |
| JP2002533414A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6683113B2 (en) * | 1999-09-23 | 2004-01-27 | Pharmacia Corporation | (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| US7115279B2 (en) | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
| EA006777B1 (ru) | 2001-06-22 | 2006-04-28 | Пфайзер Продактс Инк. | Фармацевтические композиции адсорбатов аморфного лекарственного средства |
| BR0210518A (pt) | 2001-06-22 | 2004-06-22 | Pfizer Prod Inc | Composições farmacêuticas de dispersões de drogas e polìmeros neutros |
| EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| EP1426046A4 (en) * | 2001-09-14 | 2005-11-02 | Shionogi & Co | NEW USE OF TRICYCLIC COMPOUNDS |
| US6740663B2 (en) | 2001-11-02 | 2004-05-25 | G.D. Searle, Llc | Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| US6852753B2 (en) | 2002-01-17 | 2005-02-08 | Pharmacia Corporation | Alkyl/aryl hydroxy or keto thiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
| EP1469832B2 (en) * | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
| DE60331873D1 (de) | 2002-12-20 | 2010-05-06 | Pfizer Prod Inc | Dosierungsform enthaltend einen CETP-Hemmer und einen HMG-CoA Reduktase Hemmer |
| US20040225018A1 (en) | 2003-03-17 | 2004-11-11 | Japan Tobacco Inc. | Pharmaceutical compositions of CETP inhibitors |
| EP1603554A1 (en) * | 2003-03-17 | 2005-12-14 | Japan Tobacco Inc. | Method for increasing the oral bioavailability of s-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]-2-methylpropanethioate |
| TWI393560B (zh) * | 2003-05-02 | 2013-04-21 | Japan Tobacco Inc | 包含ｓ-〔２（〔〔１-（２-乙基丁基）環己基〕羰基〕胺基）苯基〕２-甲基丙烷硫酯及ｈｍｇ輔酶ａ還原酶抑制劑之組合 |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| CA2532931A1 (en) * | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
| EP1670446A2 (en) | 2003-09-26 | 2006-06-21 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
| TW200523252A (en) * | 2003-10-31 | 2005-07-16 | Takeda Pharmaceutical | Pyridine compounds |
| FR2873368B1 (fr) * | 2004-07-26 | 2008-01-04 | Merck Sante Soc Par Actions Si | Derives de guanidine et leurs utilisations en therapeutique |
| SI1828137T1 (sl) * | 2004-12-18 | 2012-08-31 | Bayer Pharma AG | 4-cikloalkil-substituirani derivati tetrahidrokinolina in njihova uporaba kot zdravila |
| EP1844078B1 (en) | 2005-02-03 | 2016-09-28 | Bend Research, Inc | Pharmaceutical compositions with enhanced performance |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| EP1815919A1 (en) * | 2006-02-03 | 2007-08-08 | Uponor Innovation Ab | Making an elongated product |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| US20110245209A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| JP5785560B2 (ja) | 2009-12-21 | 2015-09-30 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺真菌剤としてのビス（ジフルオロメチル）ピラゾール |
| US8815775B2 (en) | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| CA2957785C (en) | 2014-08-11 | 2023-01-03 | Angion Biomedica Corporation | Cytochrome p450 inhibitors and uses thereof |
| CN107531631B (zh) * | 2014-12-31 | 2021-09-03 | 安吉昂生物医药公司 | 用于治疗疾病的方法和药剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| ATE132496T1 (de) * | 1987-07-10 | 1996-01-15 | Hoechst Ag | 3-desmethyl-mevalonsäurederivate, verfahren zu ihrer herstellung, pharmazeutische präparate auf basis dieser verbindungen, ihre verwendung sowie zwischenprodukte |
| US4906624A (en) * | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
| NZ230121A (en) * | 1988-08-29 | 1993-08-26 | Squibb & Sons Inc | Pyridine and quinoline terminal groups for hmg-coenzyme a reductase inhibitors and pharmaceutical compositions for lowering blood serum cholesterol levels |
| DE4244029A1 (de) * | 1992-12-24 | 1994-06-30 | Bayer Ag | Neue substituierte Pyridine |
-
1996
- 1996-03-20 DE DE19610932A patent/DE19610932A1/de not_active Withdrawn
-
1997
- 1997-02-25 HR HR19610932.9A patent/HRP970105A2/hr not_active Application Discontinuation
- 1997-03-07 DE DE59702034T patent/DE59702034D1/de not_active Expired - Fee Related
- 1997-03-07 EP EP97103813A patent/EP0796846B1/de not_active Expired - Lifetime
- 1997-03-07 AT AT97103813T patent/ATE194832T1/de not_active IP Right Cessation
- 1997-03-07 PT PT97103813T patent/PT796846E/pt unknown
- 1997-03-07 ES ES97103813T patent/ES2150157T3/es not_active Expired - Lifetime
- 1997-03-07 DK DK97103813T patent/DK0796846T3/da active
- 1997-03-13 US US08/816,290 patent/US5925645A/en not_active Expired - Fee Related
- 1997-03-13 AU AU16280/97A patent/AU1628097A/en not_active Abandoned
- 1997-03-14 SG SG1997000783A patent/SG50805A1/en unknown
- 1997-03-17 NZ NZ314419A patent/NZ314419A/xx unknown
- 1997-03-17 IL IL12046897A patent/IL120468A0/xx unknown
- 1997-03-17 JP JP9082454A patent/JPH09255574A/ja not_active Ceased
- 1997-03-17 CA CA002200175A patent/CA2200175A1/en not_active Abandoned
- 1997-03-18 TN TNTNSN97048A patent/TNSN97048A1/fr unknown
- 1997-03-18 BG BG101339A patent/BG101339A/xx unknown
- 1997-03-19 ZA ZA9702375A patent/ZA972375B/xx unknown
- 1997-03-19 MY MYPI97001168A patent/MY132490A/en unknown
- 1997-03-19 AR ARP970101096A patent/AR006318A1/es unknown
- 1997-03-19 HU HU9700610A patent/HUP9700610A1/hu unknown
- 1997-03-19 BR BR9701348A patent/BR9701348A/pt not_active Application Discontinuation
- 1997-03-19 PL PL97319050A patent/PL319050A1/xx unknown
- 1997-03-19 CZ CZ97843A patent/CZ84397A3/cs unknown
- 1997-03-19 SK SK361-97A patent/SK36197A3/sk unknown
- 1997-03-19 NO NO971269A patent/NO971269L/no unknown
- 1997-03-20 EE EE9700060A patent/EE9700060A/xx unknown
- 1997-03-20 TR TR97/00213A patent/TR199700213A2/xx unknown
- 1997-03-20 ID IDP970913A patent/ID16292A/id unknown
- 1997-03-20 CO CO97015054A patent/CO4520282A1/es unknown
-
1998
- 1998-12-21 US US09/217,214 patent/US6127383A/en not_active Expired - Fee Related
-
2000
- 2000-10-04 GR GR20000402236T patent/GR3034546T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL120468A0 (en) | 1997-07-13 |
| ES2150157T3 (es) | 2000-11-16 |
| ID16292A (id) | 1997-09-18 |
| TR199700213A2 (xx) | 1997-10-21 |
| NZ314419A (en) | 1998-12-23 |
| EP0796846B1 (de) | 2000-07-19 |
| US6127383A (en) | 2000-10-03 |
| EP0796846A1 (de) | 1997-09-24 |
| DE19610932A1 (de) | 1997-09-25 |
| PL319050A1 (en) | 1997-09-29 |
| JPH09255574A (ja) | 1997-09-30 |
| AU1628097A (en) | 1997-09-25 |
| BG101339A (en) | 1998-04-30 |
| CZ84397A3 (en) | 1997-10-15 |
| NO971269D0 (no) | 1997-03-19 |
| HRP970105A2 (en) | 1998-04-30 |
| ATE194832T1 (de) | 2000-08-15 |
| SK36197A3 (en) | 1997-11-05 |
| TNSN97048A1 (fr) | 2005-03-15 |
| EE9700060A (et) | 1997-10-15 |
| ZA972375B (en) | 1997-09-25 |
| HU9700610D0 (en) | 1997-05-28 |
| CA2200175A1 (en) | 1997-09-20 |
| HUP9700610A1 (hu) | 2000-08-28 |
| BR9701348A (pt) | 1998-11-10 |
| SG50805A1 (en) | 1998-07-20 |
| NO971269L (no) | 1997-09-22 |
| PT796846E (pt) | 2000-12-29 |
| GR3034546T3 (en) | 2001-01-31 |
| DE59702034D1 (de) | 2000-08-24 |
| MX9702042A (es) | 1997-09-30 |
| CO4520282A1 (es) | 1997-10-15 |
| DK0796846T3 (da) | 2000-10-23 |
| MY132490A (en) | 2007-10-31 |
| US5925645A (en) | 1999-07-20 |
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