AR005817A2 - Procedimiento para preparar acido 7-[(1,3-dihidro-1,3-dioxo-2h-isoindol-2- il)]-1,2,3,4,6,7,8,12b-octahidro-6-oxopirido[2,1-a][2]-benzazepina-4-carboxilico como intermediario util para la preparacion de inhibidores de la encefalinasa y de la enzima conversora de la angiotensina y compuestos intermediarios en dicho procedimiento. - Google Patents
Procedimiento para preparar acido 7-[(1,3-dihidro-1,3-dioxo-2h-isoindol-2- il)]-1,2,3,4,6,7,8,12b-octahidro-6-oxopirido[2,1-a][2]-benzazepina-4-carboxilico como intermediario util para la preparacion de inhibidores de la encefalinasa y de la enzima conversora de la angiotensina y compuestos intermediarios en dicho procedimiento.Info
- Publication number
- AR005817A2 AR005817A2 ARP970100582A ARP970100582A AR005817A2 AR 005817 A2 AR005817 A2 AR 005817A2 AR P970100582 A ARP970100582 A AR P970100582A AR P970100582 A ARP970100582 A AR P970100582A AR 005817 A2 AR005817 A2 AR 005817A2
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- intermediary
- oxopirido
- benzazepina
- octahidro
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 title 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 title 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Dicho ácido tiene la fórmula general (I) y el procedimiento para su preparación usa como materiales de partida derivados deftalimidoarilaminoácido. Los compuestos intermediarios en el procedimiento son también objeto del invento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36091594A | 1994-12-21 | 1994-12-21 | |
US08/535,403 US5641880A (en) | 1994-12-21 | 1995-10-24 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005817A2 true AR005817A2 (es) | 1999-07-14 |
Family
ID=23419917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100582A AR005817A2 (es) | 1994-12-21 | 1997-02-14 | Procedimiento para preparar acido 7-[(1,3-dihidro-1,3-dioxo-2h-isoindol-2- il)]-1,2,3,4,6,7,8,12b-octahidro-6-oxopirido[2,1-a][2]-benzazepina-4-carboxilico como intermediario util para la preparacion de inhibidores de la encefalinasa y de la enzima conversora de la angiotensina y compuestos intermediarios en dicho procedimiento. |
Country Status (6)
Country | Link |
---|---|
US (4) | US5641880A (es) |
EP (1) | EP0957109B1 (es) |
KR (2) | KR100378610B1 (es) |
AR (1) | AR005817A2 (es) |
IL (1) | IL128996A (es) |
ZA (1) | ZA9510713B (es) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
ES2106112T3 (es) * | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
-
1995
- 1995-10-24 US US08/535,403 patent/US5641880A/en not_active Expired - Lifetime
- 1995-11-20 EP EP99114227A patent/EP0957109B1/en not_active Expired - Lifetime
- 1995-11-20 KR KR1019970704205A patent/KR100378610B1/ko not_active IP Right Cessation
- 1995-11-20 KR KR10-2002-7014324A patent/KR100382850B1/ko not_active IP Right Cessation
- 1995-12-15 ZA ZA9510713A patent/ZA9510713B/xx unknown
- 1995-12-18 IL IL12899695A patent/IL128996A/xx not_active IP Right Cessation
-
1997
- 1997-02-14 AR ARP970100582A patent/AR005817A2/es active IP Right Grant
- 1997-11-10 US US08/967,075 patent/US5849908A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,838 patent/US5872251A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,837 patent/US5859252A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5859252A (en) | 1999-01-12 |
US5849908A (en) | 1998-12-15 |
EP0957109A3 (en) | 2001-10-10 |
EP0957109B1 (en) | 2004-05-06 |
US5872251A (en) | 1999-02-16 |
IL128996A (en) | 2001-01-28 |
KR100378610B1 (ko) | 2003-07-22 |
US5641880A (en) | 1997-06-24 |
KR100382850B1 (ko) | 2003-05-09 |
EP0957109A2 (en) | 1999-11-17 |
ZA9510713B (en) | 1996-06-20 |
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