IL128996A - Process for preparing 1,2,3,4,6,7,8,12b-octahydro-6-oxo-7-phthalimido-pyrido ¬2,1-a¾ benzazepine-4-carboxylic acids and simlar compounds as intermediates for inhibitors of enkephalinase and angiotension converting enzyme and some novel 1-(3-aryl-2-phthalimidopropanolyl)-1,2,3,4-tetrahydropyridine-carbonitriles as intermediates therefor - Google Patents
Process for preparing 1,2,3,4,6,7,8,12b-octahydro-6-oxo-7-phthalimido-pyrido ¬2,1-a¾ benzazepine-4-carboxylic acids and simlar compounds as intermediates for inhibitors of enkephalinase and angiotension converting enzyme and some novel 1-(3-aryl-2-phthalimidopropanolyl)-1,2,3,4-tetrahydropyridine-carbonitriles as intermediates thereforInfo
- Publication number
- IL128996A IL128996A IL12899695A IL12899695A IL128996A IL 128996 A IL128996 A IL 128996A IL 12899695 A IL12899695 A IL 12899695A IL 12899695 A IL12899695 A IL 12899695A IL 128996 A IL128996 A IL 128996A
- Authority
- IL
- Israel
- Prior art keywords
- intermediates
- phthalimidopropanolyl
- simlar
- carbonitriles
- enkephalinase
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 2
- WLPPCFGXINTUNZ-UHFFFAOYSA-N 5h-1-benzazepine-4-carboxylic acid Chemical class C1C(C(=O)O)=CC=NC2=CC=CC=C21 WLPPCFGXINTUNZ-UHFFFAOYSA-N 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000003729 Neprilysin Human genes 0.000 title 1
- 108090000028 Neprilysin Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36091594A | 1994-12-21 | 1994-12-21 | |
| IL11642895A IL116428A (en) | 1994-12-21 | 1995-12-18 | Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128996A true IL128996A (en) | 2001-01-28 |
Family
ID=23419917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12899695A IL128996A (en) | 1994-12-21 | 1995-12-18 | Process for preparing 1,2,3,4,6,7,8,12b-octahydro-6-oxo-7-phthalimido-pyrido ¬2,1-a¾ benzazepine-4-carboxylic acids and simlar compounds as intermediates for inhibitors of enkephalinase and angiotension converting enzyme and some novel 1-(3-aryl-2-phthalimidopropanolyl)-1,2,3,4-tetrahydropyridine-carbonitriles as intermediates therefor |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US5641880A (es) |
| EP (1) | EP0957109B1 (es) |
| KR (2) | KR100378610B1 (es) |
| AR (1) | AR005817A2 (es) |
| IL (1) | IL128996A (es) |
| ZA (1) | ZA9510713B (es) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
| CA1337654C (en) * | 1986-06-13 | 1995-11-28 | Gary A. Flynn | Fused tricyclic lactams as antihypertensive agents |
| US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
| US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
| NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
| ES2106112T3 (es) * | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
| AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
| US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
-
1995
- 1995-10-24 US US08/535,403 patent/US5641880A/en not_active Expired - Lifetime
- 1995-11-20 EP EP99114227A patent/EP0957109B1/en not_active Expired - Lifetime
- 1995-11-20 KR KR1019970704205A patent/KR100378610B1/ko not_active IP Right Cessation
- 1995-11-20 KR KR10-2002-7014324A patent/KR100382850B1/ko not_active IP Right Cessation
- 1995-12-15 ZA ZA9510713A patent/ZA9510713B/xx unknown
- 1995-12-18 IL IL12899695A patent/IL128996A/xx not_active IP Right Cessation
-
1997
- 1997-02-14 AR ARP970100582A patent/AR005817A2/es active IP Right Grant
- 1997-11-10 US US08/967,075 patent/US5849908A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,838 patent/US5872251A/en not_active Expired - Lifetime
- 1997-11-10 US US08/966,837 patent/US5859252A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AR005817A2 (es) | 1999-07-14 |
| US5859252A (en) | 1999-01-12 |
| US5849908A (en) | 1998-12-15 |
| EP0957109A3 (en) | 2001-10-10 |
| EP0957109B1 (en) | 2004-05-06 |
| US5872251A (en) | 1999-02-16 |
| KR100378610B1 (ko) | 2003-07-22 |
| US5641880A (en) | 1997-06-24 |
| KR100382850B1 (ko) | 2003-05-09 |
| EP0957109A2 (en) | 1999-11-17 |
| ZA9510713B (en) | 1996-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |