AR004893A1 - Compuestos piridil alcanol nuevos, procedimiento para su preparacion y el uso de los mismos para la preparacion de un medicamento. - Google Patents
Compuestos piridil alcanol nuevos, procedimiento para su preparacion y el uso de los mismos para la preparacion de un medicamento.Info
- Publication number
- AR004893A1 AR004893A1 ARP960105545A ARP960105545A AR004893A1 AR 004893 A1 AR004893 A1 AR 004893A1 AR P960105545 A ARP960105545 A AR P960105545A AR P960105545 A ARP960105545 A AR P960105545A AR 004893 A1 AR004893 A1 AR 004893A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- preparation
- optionally substituted
- alkyl
- atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Un compuesto de piridil alcanol de formula (I) en donde: X representa (CH2)nO, (CH2)nS o C2 alquileno; n representa 1 o 2; Ar1 representa indanilo,tetrahidronaftilo, naftilo o fenilo, cuyos ultimos dos grupos pueden ser substituidos poruno o mas substituyentes seleccionados de cloro, fluoro, OR1,O(CH2)mCONR20R21, C(O)R2, alquilo C1-6 (opcionalmente substituido) por uno o mas atomos de fluor), piridilo, tiazinilo, fenilo o alquilfenilo C7-9, cuyosultimos dos grupos estanopcional mente substituidos por uno o mas substituyentes seleccionados de halo, nitro, OR3, alquilo C1-6 (opcionalmentesubstituido por uno o mas atomos de fluor), C(O)R4, C(O)OR5, C(O)N(R6)R7, CN, CH2OR14, CH2NR15R16, N(R8)R9,N(R10)SO2R11, N( R12)C(O)R13, OC(O)R19, ySO2NR17R18; m representa un entero de 1 a 3; R1, R2 y R3 representan independientemente H, alquilo C1-10 (opcionalmente substituido por uno o masatomos de fluor), alquilfenilo C7-9 o fenilo, cuyoultimo grupo es opcionalmente substituido por hidroxi; y R4, R5, R6, R7, R8, R9, R10, R11,R12, R13, R14, R15, R16, R17, R18, R19, R20 y R21 representan independientemente H, alquilo C1C6 (opcionalmente substituido por uno omasatomos de fluor) o fenilo; en la cual cualquier grupo alquilo presente puede ser interrumpido por uno o mas atomos de oxigeno; siempre que cuando Xrepresenta CH2CH2, Ar1 no puede representar fenilo o fenilo substituido con uno o massubstituyentes OR1, en e l que R1 representa alquilo C1-10; o un derivadofarmaceuticamente aceptable del mismo, se puede usar para el tratamiento de una enfermedad reversible obstructiva de los conductos respiratorios o decondiciones alergicas de lapiel, nariz y ojos. Tambi en describe un procedimiento para su preparacion y el uso para la preparacion de un
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9524920.7A GB9524920D0 (en) | 1995-12-06 | 1995-12-06 | Compounds |
GBGB9609403.2A GB9609403D0 (en) | 1996-05-04 | 1996-05-04 | Compounds |
GBGB9622412.6A GB9622412D0 (en) | 1996-10-22 | 1996-10-22 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR004893A1 true AR004893A1 (es) | 1999-03-10 |
Family
ID=27268017
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP960105545A AR004893A1 (es) | 1995-12-06 | 1996-12-06 | Compuestos piridil alcanol nuevos, procedimiento para su preparacion y el uso de los mismos para la preparacion de un medicamento. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5977105A (es) |
EP (1) | EP0865431A2 (es) |
JP (1) | JP2000501700A (es) |
KR (1) | KR19990071968A (es) |
CN (1) | CN1208403A (es) |
AR (1) | AR004893A1 (es) |
AU (1) | AU711772B2 (es) |
BR (1) | BR9611555A (es) |
CZ (1) | CZ172498A3 (es) |
EE (1) | EE9800172A (es) |
HU (1) | HUP9900143A3 (es) |
IL (1) | IL124768A0 (es) |
IS (1) | IS4739A (es) |
MX (1) | MX9804295A (es) |
NO (1) | NO982566L (es) |
NZ (1) | NZ323521A (es) |
SA (1) | SA97170633A (es) |
SK (1) | SK73998A3 (es) |
TR (1) | TR199801000T2 (es) |
WO (1) | WO1997020815A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998037070A1 (fr) * | 1997-02-21 | 1998-08-27 | Takeda Chemical Industries, Ltd. | Composes a anneaux condenses, leur procede de production et leur utilisation |
AU6753298A (en) * | 1997-03-25 | 1998-10-20 | Astra Pharmaceuticals Limited | Novel pyridine derivatives and pharmaceutical compositions containing them |
CA2284200A1 (en) * | 1997-03-25 | 1998-10-01 | Astra Pharmaceuticals Ltd. | Novel pyridine derivatives and pharmaceutical compositions containing them |
EP0984961B1 (en) * | 1997-04-01 | 2001-06-20 | AstraZeneca AB | Novel pyridine derivatives and pharmaceutical compositions containing them |
SE9803107D0 (sv) * | 1998-09-14 | 1998-09-14 | Astra Pharma Prod | Novel Compunds |
SE9803277D0 (sv) * | 1998-09-25 | 1998-09-25 | Astra Pharma Prod | Novel compounds |
SE9803279D0 (sv) * | 1998-09-25 | 1998-09-25 | Astra Pharma Prod | Novel compounds |
SE9803280D0 (sv) * | 1998-09-25 | 1998-09-25 | Astra Pharma Prod | Novel compounds |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
US6307049B1 (en) * | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
EP1140844A1 (en) * | 1999-01-08 | 2001-10-10 | Vertex Pharmaceuticals Incorporated | Process for the formation of intermediates useful for the preparation of pharmaceuticals |
SE9901079D0 (sv) * | 1999-03-23 | 1999-03-23 | Astra Ab | Novel compounds |
CA2314458A1 (en) * | 1999-08-02 | 2001-02-02 | Kazumi Okuro | Process for production of 3-(3-pyridyl)-1-propanol derivatives |
US6376524B1 (en) | 2000-06-21 | 2002-04-23 | Sunesis Pharmaceuticals, Inc. | Triphenyl compounds as interleukin-4 antagonists |
GB0321538D0 (en) * | 2003-09-13 | 2003-10-15 | Glaxo Group Ltd | Therapeutically useful compounds |
MX2009004904A (es) * | 2006-11-09 | 2009-05-19 | Bausch & Lomb | Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos. |
WO2008154484A1 (en) | 2007-06-08 | 2008-12-18 | Mannkind Corporation | Ire-1a inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA877650B (en) * | 1986-10-14 | 1988-12-28 | Searle & Co | Alpha-(phenylalkyl)pyridinealkanol derivatives |
AU7975887A (en) * | 1986-10-16 | 1988-04-21 | G.D. Searle & Co. | Alpha-((phenylmethoxy)methyl)pyridine alkanols |
US5248685A (en) * | 1989-04-07 | 1993-09-28 | Pfizer Inc. | Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma |
-
1996
- 1996-12-04 BR BR9611555A patent/BR9611555A/pt unknown
- 1996-12-04 HU HU9900143A patent/HUP9900143A3/hu unknown
- 1996-12-04 WO PCT/SE1996/001595 patent/WO1997020815A1/en not_active Application Discontinuation
- 1996-12-04 NZ NZ323521A patent/NZ323521A/en unknown
- 1996-12-04 SK SK739-98A patent/SK73998A3/sk unknown
- 1996-12-04 TR TR1998/01000T patent/TR199801000T2/xx unknown
- 1996-12-04 CZ CZ981724A patent/CZ172498A3/cs unknown
- 1996-12-04 IL IL12476896A patent/IL124768A0/xx unknown
- 1996-12-04 JP JP9521207A patent/JP2000501700A/ja active Pending
- 1996-12-04 US US08/793,918 patent/US5977105A/en not_active Expired - Fee Related
- 1996-12-04 KR KR1019980704258A patent/KR19990071968A/ko not_active Application Discontinuation
- 1996-12-04 EP EP96941295A patent/EP0865431A2/en not_active Withdrawn
- 1996-12-04 CN CN96199831A patent/CN1208403A/zh active Pending
- 1996-12-04 EE EE9800172A patent/EE9800172A/xx unknown
- 1996-12-04 AU AU10480/97A patent/AU711772B2/en not_active Ceased
- 1996-12-06 AR ARP960105545A patent/AR004893A1/es unknown
-
1997
- 1997-02-23 SA SA97170633A patent/SA97170633A/ar unknown
-
1998
- 1998-05-12 IS IS4739A patent/IS4739A/is unknown
- 1998-05-29 MX MX9804295A patent/MX9804295A/es unknown
- 1998-06-04 NO NO982566A patent/NO982566L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ172498A3 (cs) | 1998-12-16 |
SA97170633A (ar) | 2005-12-03 |
MX9804295A (es) | 1998-09-30 |
HUP9900143A2 (hu) | 1999-05-28 |
TR199801000T2 (xx) | 1998-08-21 |
JP2000501700A (ja) | 2000-02-15 |
BR9611555A (pt) | 1999-03-02 |
HUP9900143A3 (en) | 2000-04-28 |
SK73998A3 (en) | 1999-02-11 |
IL124768A0 (en) | 1999-11-30 |
AU1048097A (en) | 1997-06-27 |
EP0865431A2 (en) | 1998-09-23 |
WO1997020815A1 (en) | 1997-06-12 |
NO982566L (no) | 1998-07-24 |
NO982566D0 (no) | 1998-06-04 |
EE9800172A (et) | 1998-12-15 |
IS4739A (is) | 1998-05-12 |
KR19990071968A (ko) | 1999-09-27 |
CN1208403A (zh) | 1999-02-17 |
NZ323521A (en) | 1999-10-28 |
AU711772B2 (en) | 1999-10-21 |
US5977105A (en) | 1999-11-02 |
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