AR004777A1 - Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene. - Google Patents

Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene.

Info

Publication number
AR004777A1
AR004777A1 ARP960105360A ARP960105360A AR004777A1 AR 004777 A1 AR004777 A1 AR 004777A1 AR P960105360 A ARP960105360 A AR P960105360A AR P960105360 A ARP960105360 A AR P960105360A AR 004777 A1 AR004777 A1 AR 004777A1
Authority
AR
Argentina
Prior art keywords
alkyl
drugs
imidazolidin
thioxo
alkynyl
Prior art date
Application number
ARP960105360A
Other languages
English (en)
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of AR004777A1 publication Critical patent/AR004777A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Uso de derivados de 2-tioxo-imidazolidin-4-ona para preparar un medicamento para incrementar la concentración de colesterol HDL en la sangre de un mamíferoque necesite una concentración elevada de colesterol HDL en la sangre, que comprende una cantidad terapéuticamente efectiva, de un compuesto de fórmula(I), en donde R es alquilo; un heterociclo N, O ó S aromático substituido o no substituido; arilo substituido o no substituido, arilalquilo, benzhidrilo óindanilo, en los que los substituyentes son uno a tres miembros independientemente seleccionado del grupo que consiste en alquilo, alcoxi,alquiltio, alquenilo, alquinilo, halo, perfluoralquilo, perfluoralcoxi o hidroxi; y R1 es arilo, alquilo, alquenilo, alquinilo, o arilo substituidodonde los substituyentes son uno a tres miembros independientemente seleccionados del grupo que consiste en alquilo, alcoxi, alquiltio, alquenilo,alquinilo, halo, perfluoralquilo, perfluoralcoxi o hidroxi, y al menos un vehículo farmacéuticamente aceptable; y medicamentos que los contienen.
ARP960105360A 1995-11-28 1996-11-27 Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene. AR004777A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/563,325 US5554607A (en) 1995-11-28 1995-11-28 Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of atherosclerosis

Publications (1)

Publication Number Publication Date
AR004777A1 true AR004777A1 (es) 1999-03-10

Family

ID=24250053

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960105360A AR004777A1 (es) 1995-11-28 1996-11-27 Uso de derivados de 2-tioxo-imidazolidin-4-ona para la preparacion de medicamentos y medicamentos que los contiene.

Country Status (3)

Country Link
US (1) US5554607A (es)
AR (1) AR004777A1 (es)
ZA (1) ZA969973B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1127697A (en) * 1995-11-28 1997-06-19 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives and their use for increasing hdl cholesterol concentration
WO1997019931A1 (en) * 1995-11-28 1997-06-05 American Home Products Corporation 2-(substituted sulfanyl)-3,5-dihydro-imidazol-4-one derivatives
US5821372A (en) * 1995-11-28 1998-10-13 American Home Products Corporation 2-thioxo-imidazolidin-4-one derivatives
AU707732B2 (en) * 1996-03-07 1999-07-15 American Home Products Corporation 2-thioxotetrahydropyrimidin-4-one derivatives
JP2001503769A (ja) * 1996-11-14 2001-03-21 アメリカン・ホーム・プロダクツ・コーポレイション 抗アテローム性動脈硬化症薬としての置換テトラヒドロ―１，３，５―トリアジン―２［１ｈ］―チオン
FR2823209B1 (fr) * 2001-04-04 2003-12-12 Fournier Lab Sa Nouvelles thiohydantoines et leur utilisation en therapeutique
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
EP2004181B3 (en) 2006-03-27 2023-05-24 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2013205325B2 (en) * 2006-03-27 2016-03-24 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2016201061B2 (en) * 2006-03-27 2017-03-02 The Regents Of The University Of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
US8110594B2 (en) 2006-03-29 2012-02-07 The Regents Of The University Of California Diarylthiohydantoin compounds
CA2966280A1 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
KR101753826B1 (ko) 2009-05-12 2017-07-04 얀센 파마슈티칼즈, 인코포레이티드 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도
CN106983749A (zh) 2010-02-16 2017-07-28 亚拉冈制药公司 雄激素受体调节剂及其用途
ES2836424T3 (es) 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
JOP20200076A1 (ar) 2017-10-16 2020-04-30 Aragon Pharmaceuticals Inc مضادات أندروجين لعلاج سرطان البروستاتا غير النقيلي المقاوم للاستئصال

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4887030A (es) * 1972-02-24 1973-11-16
US5137904A (en) * 1989-05-30 1992-08-11 G. D. Searle & Co. Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
JPH04297461A (ja) * 1991-03-27 1992-10-21 Otsuka Pharmaceut Factory Inc ２−チオヒダントイン誘導体
DE4207254A1 (de) * 1992-03-07 1993-09-09 Cassella Ag 4-oxo-2-thioxoimidazolidin-derivate
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
DE4228717A1 (de) * 1992-08-28 1994-03-03 Cassella Ag Imidazolidin-Derivate
WO1994020460A1 (en) * 1993-03-11 1994-09-15 Smithkline Beecham Corporation Chemical compounds

Also Published As

Publication number Publication date
US5554607A (en) 1996-09-10
ZA969973B (en) 1998-05-27

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