AP508A - Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. - Google Patents
Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. Download PDFInfo
- Publication number
- AP508A AP508A APAP/P/1994/000605A AP9400605A AP508A AP 508 A AP508 A AP 508A AP 9400605 A AP9400605 A AP 9400605A AP 508 A AP508 A AP 508A
- Authority
- AP
- ARIPO
- Prior art keywords
- phe
- tic
- tyr
- compound according
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- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9300012A SE9300012D0 (sv) | 1993-01-05 | 1993-01-05 | New peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9400605A0 AP9400605A0 (en) | 1994-01-31 |
| AP508A true AP508A (en) | 1996-07-22 |
Family
ID=20388466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1994/000605A AP508A (en) | 1993-01-05 | 1994-01-05 | Novel opioid analogs that are 9 (delta) opioid receptor antagonists, their syntheis and their use as analgesic and immunosupressive compounds. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5602099A (et) |
| EP (1) | EP0678099A1 (et) |
| JP (1) | JPH08505386A (et) |
| KR (1) | KR960700269A (et) |
| CN (1) | CN1096515A (et) |
| AP (1) | AP508A (et) |
| AU (1) | AU681372B2 (et) |
| CA (1) | CA2152380A1 (et) |
| CZ (1) | CZ171195A3 (et) |
| EE (1) | EE9400326A (et) |
| FI (1) | FI953302A (et) |
| HU (1) | HUT72597A (et) |
| IL (1) | IL108169A0 (et) |
| IS (1) | IS4115A (et) |
| LV (1) | LV10962B (et) |
| MX (1) | MX9400255A (et) |
| NO (1) | NO952650L (et) |
| NZ (1) | NZ259597A (et) |
| PL (1) | PL309778A1 (et) |
| SE (1) | SE9300012D0 (et) |
| SI (1) | SI9400005A (et) |
| SK (1) | SK83995A3 (et) |
| WO (1) | WO1994015959A1 (et) |
| YU (1) | YU394A (et) |
| ZA (1) | ZA9455B (et) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU221092B1 (en) * | 1993-12-23 | 2002-08-28 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| IS4261A (is) * | 1994-02-21 | 1995-08-22 | Astra Aktiebolag | Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra |
| IL114046A0 (en) * | 1994-06-20 | 1995-10-31 | Astra Ab | New opioid peptide antagonists |
| US6184208B1 (en) | 1994-06-29 | 2001-02-06 | Immunotech Developments Inc. | Peptide, a method for its preparation and a pharmaceutical composition containing the peptide |
| RU2067000C1 (ru) * | 1994-06-29 | 1996-09-27 | Владислав Исакович Дейгин | Пептид и способ его получения |
| SE9402880D0 (sv) * | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
| US5780589A (en) * | 1994-11-30 | 1998-07-14 | The United States Of America As Represented By The Department Of Health And Human Services | Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof |
| EP0837857A4 (en) * | 1995-03-29 | 1998-08-05 | Merck & Co Inc | FARNESYL-PROTEIN TRANSFERASE INHIBITORS |
| CA2216532A1 (en) * | 1995-03-29 | 1996-10-31 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
| DE19512484A1 (de) | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
| SE9600769D0 (sv) * | 1996-02-28 | 1996-02-28 | Astra Ab | Compounds useful as analgesic |
| CA2291778A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6703381B1 (en) | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| US6306576B1 (en) * | 1999-02-19 | 2001-10-23 | Cleveland Clinic Foundation | Diagnostic methods for asthma |
| US7601739B2 (en) | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| JP2008514612A (ja) * | 2004-09-23 | 2008-05-08 | ミシャロウ、アレクサンダー | 対抗適応を誘発することにより神経伝達物質系を調節する方法 |
| WO2015200828A1 (en) * | 2014-06-27 | 2015-12-30 | H. Lee Moffit Cancer Center And Research Institute, Inc. | Conjugates for immunotherapy |
-
1993
- 1993-01-05 SE SE9300012A patent/SE9300012D0/xx unknown
- 1993-12-20 CZ CZ951711A patent/CZ171195A3/cs unknown
- 1993-12-20 KR KR1019950702750A patent/KR960700269A/ko not_active Application Discontinuation
- 1993-12-20 CA CA002152380A patent/CA2152380A1/en not_active Abandoned
- 1993-12-20 JP JP6515914A patent/JPH08505386A/ja active Pending
- 1993-12-20 HU HU9502041A patent/HUT72597A/hu unknown
- 1993-12-20 EP EP94904365A patent/EP0678099A1/en not_active Withdrawn
- 1993-12-20 PL PL93309778A patent/PL309778A1/xx unknown
- 1993-12-20 SK SK839-95A patent/SK83995A3/sk unknown
- 1993-12-20 WO PCT/SE1993/001090 patent/WO1994015959A1/en not_active Application Discontinuation
- 1993-12-20 AU AU58448/94A patent/AU681372B2/en not_active Ceased
- 1993-12-20 NZ NZ259597A patent/NZ259597A/en unknown
- 1993-12-24 IL IL10816993A patent/IL108169A0/xx unknown
- 1993-12-27 IS IS4115A patent/IS4115A/is unknown
-
1994
- 1994-01-04 US US08/176,938 patent/US5602099A/en not_active Expired - Fee Related
- 1994-01-04 MX MX9400255A patent/MX9400255A/es unknown
- 1994-01-05 SI SI9400005A patent/SI9400005A/sl unknown
- 1994-01-05 YU YU394A patent/YU394A/sh unknown
- 1994-01-05 ZA ZA9455A patent/ZA9455B/xx unknown
- 1994-01-05 CN CN94100129A patent/CN1096515A/zh active Pending
- 1994-01-05 AP APAP/P/1994/000605A patent/AP508A/en active
- 1994-11-03 EE EE9400326A patent/EE9400326A/et unknown
-
1995
- 1995-06-29 LV LVP-95-197A patent/LV10962B/en unknown
- 1995-07-04 NO NO952650A patent/NO952650L/no not_active Application Discontinuation
- 1995-07-04 FI FI953302A patent/FI953302A/fi unknown
Non-Patent Citations (1)
| Title |
|---|
| NONE * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ259597A (en) | 1996-07-26 |
| PL309778A1 (en) | 1995-11-13 |
| IL108169A0 (en) | 1994-04-12 |
| FI953302A0 (fi) | 1995-07-04 |
| LV10962A (lv) | 1995-12-20 |
| KR960700269A (ko) | 1996-01-19 |
| AU5844894A (en) | 1994-08-15 |
| AP9400605A0 (en) | 1994-01-31 |
| WO1994015959A1 (en) | 1994-07-21 |
| CN1096515A (zh) | 1994-12-21 |
| SK83995A3 (en) | 1996-09-04 |
| CZ171195A3 (en) | 1996-09-11 |
| CA2152380A1 (en) | 1994-07-21 |
| YU394A (sh) | 1997-07-31 |
| ZA9455B (en) | 1994-07-05 |
| EE9400326A (et) | 1996-04-15 |
| NO952650L (no) | 1995-08-30 |
| LV10962B (en) | 1997-04-20 |
| HUT72597A (en) | 1996-05-28 |
| SI9400005A (en) | 1994-12-31 |
| SE9300012D0 (sv) | 1993-01-05 |
| US5602099A (en) | 1997-02-11 |
| AU681372B2 (en) | 1997-08-28 |
| NO952650D0 (no) | 1995-07-04 |
| FI953302A (fi) | 1995-07-04 |
| MX9400255A (es) | 1994-07-29 |
| JPH08505386A (ja) | 1996-06-11 |
| HU9502041D0 (en) | 1995-09-28 |
| IS4115A (is) | 1994-07-06 |
| EP0678099A1 (en) | 1995-10-25 |
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