AP393A - Substituted pipecolinic and acid derivatives as HIV protease inhibitors. - Google Patents

Substituted pipecolinic and acid derivatives as HIV protease inhibitors. Download PDF

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Publication number
AP393A
AP393A APAP/P/1993/000495A AP9300495A AP393A AP 393 A AP393 A AP 393A AP 9300495 A AP9300495 A AP 9300495A AP 393 A AP393 A AP 393A
Authority
AP
ARIPO
Prior art keywords
butyl
tert
hydroxy
carboxamide
amino
Prior art date
Application number
APAP/P/1993/000495A
Other languages
English (en)
Other versions
AP9300495A0 (en
Inventor
Paul Cates Anderson
Francois Soucy
Christianneof YOAKIM
Pierre Lavalle
Peirre Louise Beaulieu
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Publication of AP9300495A0 publication Critical patent/AP9300495A0/xx
Application granted granted Critical
Publication of AP393A publication Critical patent/AP393A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
APAP/P/1993/000495A 1992-03-13 1993-03-10 Substituted pipecolinic and acid derivatives as HIV protease inhibitors. AP393A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85071692A 1992-03-13 1992-03-13

Publications (2)

Publication Number Publication Date
AP9300495A0 AP9300495A0 (en) 1993-04-30
AP393A true AP393A (en) 1995-08-07

Family

ID=25308925

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000495A AP393A (en) 1992-03-13 1993-03-10 Substituted pipecolinic and acid derivatives as HIV protease inhibitors.

Country Status (25)

Country Link
US (1) US5807870A (sv)
EP (1) EP0560268B1 (sv)
JP (1) JP3258422B2 (sv)
KR (1) KR950700253A (sv)
AP (1) AP393A (sv)
AT (1) ATE116640T1 (sv)
AU (1) AU670582B2 (sv)
CA (1) CA2131185C (sv)
CZ (1) CZ285589B6 (sv)
DE (1) DE69300043T2 (sv)
DK (1) DK0560268T3 (sv)
ES (1) ES2066623T3 (sv)
FI (1) FI944217A (sv)
GR (1) GR3015622T3 (sv)
HU (2) HUT70617A (sv)
IL (1) IL105035A (sv)
NO (1) NO302570B1 (sv)
NZ (1) NZ251267A (sv)
OA (1) OA10092A (sv)
PH (1) PH30734A (sv)
PL (1) PL176362B1 (sv)
RU (1) RU2140911C1 (sv)
SK (1) SK280161B6 (sv)
WO (1) WO1993018003A1 (sv)
ZA (1) ZA931776B (sv)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
MXPA93002392A (es) 1992-03-11 2005-02-04 Narhex Ltd Derivados amino de hidrocarburos-oxo e hidroxi-substituidos.
BR9306058A (pt) 1992-03-11 1997-11-18 Narhex Ltd Derivados de amina de hidrocarbonetos oxo- e hidroxi- substituidos
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
DK0656887T3 (da) 1992-08-25 1999-07-05 Searle & Co Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
CA2137406C (en) * 1994-12-06 2005-09-13 Pierre Louis Beaulieu Process for key intermediates for hiv protease inhibitors
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
SI1248600T1 (sl) 2000-01-19 2008-08-31 Abbott Lab Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV
AU2001252958A1 (en) * 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
ATE302751T1 (de) 2000-06-30 2005-09-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
US6982264B2 (en) * 2001-06-27 2006-01-03 Elan Pharmaceuticals, Inc. Substituted alcohols useful in treatment of Alzheimer's disease
US20070213407A1 (en) * 2001-06-29 2007-09-13 Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc Compounds to treat Alzheimer's disease
US7662852B2 (en) 2003-05-22 2010-02-16 Lead Chemical Co., Ltd. Compounds and preparations having antiviral effect
EP1761487B1 (en) * 2004-06-10 2013-08-07 Board of Trustees of Michigan State University Synthesis of caprolactam from lysine
EP1910317B1 (en) * 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino linked compounds
EP2148856B8 (en) * 2007-02-20 2016-04-06 Board of Trustees of Michigan State University Catalytic deamination for caprolactam production
WO2008112289A2 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-protease inhibitor conjugates
US9095620B2 (en) 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
EP2318373A1 (en) * 2008-07-24 2011-05-11 Draths Corporation Methods of making cyclic amide monomers, and related derivatives and methods
JP2012530069A (ja) 2009-06-12 2012-11-29 ネクター セラピューティックス プロテアーゼ阻害剤、水溶性非ペプチドオリゴマーおよび親油性部分を含む共有結合体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346847A2 (en) * 1988-06-13 1989-12-20 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264106B1 (en) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
ZA931777B (en) * 1992-03-13 1993-09-23 Bio Mega Boehringer Ingelheim Substituted pyrrolidine derivatives as HIV protease inhibitors.
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
GB2292146A (en) * 1994-08-11 1996-02-14 Merck & Co Inc HIV protease inhibitors useful for the treatment of AIDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346847A2 (en) * 1988-06-13 1989-12-20 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives

Also Published As

Publication number Publication date
US5807870A (en) 1998-09-15
PH30734A (en) 1997-10-17
DE69300043D1 (de) 1995-02-16
NZ251267A (en) 1996-09-25
DK0560268T3 (da) 1995-06-12
FI944217A0 (sv) 1994-09-13
NO302570B1 (no) 1998-03-23
ES2066623T3 (es) 1995-03-01
FI944217A (sv) 1994-09-13
RU2140911C1 (ru) 1999-11-10
HUT70617A (en) 1995-10-30
RU94040841A (ru) 1996-07-20
KR950700253A (ko) 1995-01-16
AP9300495A0 (en) 1993-04-30
CA2131185C (en) 1997-05-27
SK280161B6 (sk) 1999-09-10
NO943383L (no) 1994-09-12
WO1993018003A1 (en) 1993-09-16
AU670582B2 (en) 1996-07-25
ZA931776B (en) 1993-09-24
CZ223294A3 (en) 1995-11-15
JP3258422B2 (ja) 2002-02-18
OA10092A (en) 1996-12-18
SK109094A3 (en) 1995-05-10
JPH0673004A (ja) 1994-03-15
HU211854A9 (en) 1995-12-28
DE69300043T2 (de) 1995-05-24
GR3015622T3 (en) 1995-06-30
EP0560268A1 (en) 1993-09-15
IL105035A0 (en) 1993-07-08
EP0560268B1 (en) 1995-01-04
PL176362B1 (pl) 1999-05-31
HU9402613D0 (en) 1994-11-28
ATE116640T1 (de) 1995-01-15
CA2131185A1 (en) 1993-09-16
NO943383D0 (no) 1994-09-12
AU3880893A (en) 1993-10-05
IL105035A (en) 1997-07-13
CZ285589B6 (cs) 1999-09-15

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