ZA931776B - Substituted pipecolinic acid derivatives as HIV protease inhibitors. - Google Patents

Substituted pipecolinic acid derivatives as HIV protease inhibitors.

Info

Publication number
ZA931776B
ZA931776B ZA931776A ZA931776A ZA931776B ZA 931776 B ZA931776 B ZA 931776B ZA 931776 A ZA931776 A ZA 931776A ZA 931776 A ZA931776 A ZA 931776A ZA 931776 B ZA931776 B ZA 931776B
Authority
ZA
South Africa
Prior art keywords
acid derivatives
protease inhibitors
hiv protease
pipecolinic acid
substituted
Prior art date
Application number
ZA931776A
Other languages
English (en)
Inventor
Paul Cates Anderson
Francois Soucy
Christianne Yoakim
Pierre Lavalle
Peirre Louise Beaulieu
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of ZA931776B publication Critical patent/ZA931776B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
ZA931776A 1992-03-13 1993-03-12 Substituted pipecolinic acid derivatives as HIV protease inhibitors. ZA931776B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85071692A 1992-03-13 1992-03-13

Publications (1)

Publication Number Publication Date
ZA931776B true ZA931776B (en) 1993-09-24

Family

ID=25308925

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA931776A ZA931776B (en) 1992-03-13 1993-03-12 Substituted pipecolinic acid derivatives as HIV protease inhibitors.

Country Status (25)

Country Link
US (1) US5807870A (sv)
EP (1) EP0560268B1 (sv)
JP (1) JP3258422B2 (sv)
KR (1) KR950700253A (sv)
AP (1) AP393A (sv)
AT (1) ATE116640T1 (sv)
AU (1) AU670582B2 (sv)
CA (1) CA2131185C (sv)
CZ (1) CZ285589B6 (sv)
DE (1) DE69300043T2 (sv)
DK (1) DK0560268T3 (sv)
ES (1) ES2066623T3 (sv)
FI (1) FI944217A (sv)
GR (1) GR3015622T3 (sv)
HU (2) HUT70617A (sv)
IL (1) IL105035A (sv)
NO (1) NO302570B1 (sv)
NZ (1) NZ251267A (sv)
OA (1) OA10092A (sv)
PH (1) PH30734A (sv)
PL (1) PL176362B1 (sv)
RU (1) RU2140911C1 (sv)
SK (1) SK280161B6 (sv)
WO (1) WO1993018003A1 (sv)
ZA (1) ZA931776B (sv)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE253050T1 (de) 1992-03-11 2003-11-15 Narhex Ltd Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US5679688A (en) 1992-03-11 1997-10-21 Narhex Limited Quinaldoyl-amine derivatives of oxo-and hydroxy-substituted hydrocarbons
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
ATE218541T1 (de) 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
CA2137406C (en) * 1994-12-06 2005-09-13 Pierre Louis Beaulieu Process for key intermediates for hiv protease inhibitors
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6251906B1 (en) 1998-05-15 2001-06-26 Abbott Laboratories Retroviral protease inhibiting compounds
DK1917958T3 (da) 2000-01-19 2012-09-24 Abbott Lab Forbedrede farmaceutiske formuleringer af HIV proteaseinhibitorer
US6992081B2 (en) 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
DE60124080T2 (de) 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
EP1299352B1 (en) 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US20030096864A1 (en) * 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
US6846813B2 (en) * 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
CA2452039A1 (en) * 2001-06-27 2003-01-09 Elan Pharmaceuticals, Inc. Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease
US20070213407A1 (en) * 2001-06-29 2007-09-13 Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc Compounds to treat Alzheimer's disease
JP4482883B2 (ja) 2003-05-22 2010-06-16 リードケミカル株式会社 抗ウイルス作用を有する化合物およびその配合剤
WO2005123669A1 (en) * 2004-06-10 2005-12-29 Board Of Trustees Of Michigan State University Synthesis of caprolactam from lysine
WO2007015805A1 (en) * 2005-07-20 2007-02-08 Eli Lilly And Company 1-amino linked compounds
EP2148856B8 (en) * 2007-02-20 2016-04-06 Board of Trustees of Michigan State University Catalytic deamination for caprolactam production
KR101518079B1 (ko) 2007-03-12 2015-05-06 넥타르 테라퓨틱스 올리고머-프로테아제 억제제 컨주게이트
US9095620B2 (en) 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
BRPI0911733A8 (pt) * 2008-07-24 2017-10-03 Amyris Inc Método para produzir uma amida cíclica, método para produzir uma poliamida, método para produzir a-amino-e-caprolactama, método para produzir e-caprolactama, método para produzir policaprolactama, processo para a síntese de a-amino-e-caprolactama, processo para a síntese da e-caprolactama e método para produzir nylon 6
WO2010144869A2 (en) 2009-06-12 2010-12-16 Nektar Therapeutics Protease inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264106B1 (en) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
ZA931777B (en) * 1992-03-13 1993-09-23 Bio Mega Boehringer Ingelheim Substituted pyrrolidine derivatives as HIV protease inhibitors.
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Creation and resolution of 2 tert-butylcarboxamidopiprazine
US5480887A (en) * 1994-02-02 1996-01-02 Eli Lilly And Company Protease inhibitors
GB2292146A (en) * 1994-08-11 1996-02-14 Merck & Co Inc HIV protease inhibitors useful for the treatment of AIDS

Also Published As

Publication number Publication date
HUT70617A (en) 1995-10-30
DK0560268T3 (da) 1995-06-12
CZ223294A3 (en) 1995-11-15
HU211854A9 (en) 1995-12-28
CZ285589B6 (cs) 1999-09-15
WO1993018003A1 (en) 1993-09-16
JPH0673004A (ja) 1994-03-15
PL176362B1 (pl) 1999-05-31
NO943383L (no) 1994-09-12
RU2140911C1 (ru) 1999-11-10
KR950700253A (ko) 1995-01-16
NO302570B1 (no) 1998-03-23
ES2066623T3 (es) 1995-03-01
NO943383D0 (no) 1994-09-12
IL105035A (en) 1997-07-13
RU94040841A (ru) 1996-07-20
AU3880893A (en) 1993-10-05
NZ251267A (en) 1996-09-25
EP0560268B1 (en) 1995-01-04
PH30734A (en) 1997-10-17
JP3258422B2 (ja) 2002-02-18
AP393A (en) 1995-08-07
HU9402613D0 (en) 1994-11-28
IL105035A0 (en) 1993-07-08
CA2131185A1 (en) 1993-09-16
US5807870A (en) 1998-09-15
FI944217A0 (sv) 1994-09-13
ATE116640T1 (de) 1995-01-15
DE69300043T2 (de) 1995-05-24
SK280161B6 (sk) 1999-09-10
AP9300495A0 (en) 1993-04-30
EP0560268A1 (en) 1993-09-15
AU670582B2 (en) 1996-07-25
SK109094A3 (en) 1995-05-10
DE69300043D1 (de) 1995-02-16
OA10092A (en) 1996-12-18
CA2131185C (en) 1997-05-27
FI944217A (sv) 1994-09-13
GR3015622T3 (en) 1995-06-30

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