AP3518A - NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES - Google Patents

NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES

Info

Publication number
AP3518A
AP3518A AP2013006868A AP2013006868A AP3518A AP 3518 A AP3518 A AP 3518A AP 2013006868 A AP2013006868 A AP 2013006868A AP 2013006868 A AP2013006868 A AP 2013006868A AP 3518 A AP3518 A AP 3518A
Authority
AP
ARIPO
Prior art keywords
pyrrolo
benzodiazepines
dihydro
substituted
phenyl derivatives
Prior art date
Application number
AP2013006868A
Other languages
English (en)
Other versions
AP2013006868A0 (en
Inventor
Lieven Meerpoel
Louis Jules Roger Marie Maes
Wit Kelly De
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP2013006868A0 publication Critical patent/AP2013006868A0/xx
Application granted granted Critical
Publication of AP3518A publication Critical patent/AP3518A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2013006868A 2010-11-24 2011-11-18 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES AP3518A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10192321 2010-11-24
PCT/EP2011/070458 WO2012069380A1 (fr) 2010-11-24 2011-11-18 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]-benzodiazépines et 6h-pyrrolo[1,2-a][1,4]benzodiazépines antifongiques substituées avec des dérivés de phényle

Publications (2)

Publication Number Publication Date
AP2013006868A0 AP2013006868A0 (en) 2013-05-31
AP3518A true AP3518A (en) 2016-01-11

Family

ID=43607927

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013006868A AP3518A (en) 2010-11-24 2011-11-18 NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES

Country Status (20)

Country Link
US (1) US9040523B2 (fr)
EP (1) EP2643324B1 (fr)
JP (1) JP5795076B2 (fr)
KR (1) KR101858630B1 (fr)
CN (2) CN103228659B (fr)
AP (1) AP3518A (fr)
AU (1) AU2011333918B2 (fr)
BR (1) BR112013012547A2 (fr)
CA (1) CA2816395C (fr)
EA (1) EA020837B1 (fr)
ES (1) ES2582313T3 (fr)
HK (1) HK1254681A1 (fr)
IL (1) IL226442A (fr)
MX (1) MX2013005857A (fr)
MY (1) MY162808A (fr)
NZ (1) NZ611892A (fr)
SG (1) SG190141A1 (fr)
UA (1) UA109676C2 (fr)
WO (1) WO2012069380A1 (fr)
ZA (1) ZA201303772B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2818623C (fr) * 2010-12-21 2019-03-12 Janssen Pharmaceutica Nv 5,6-dihydro-4h-pyrrolo-[1,2-a][1,4]benzodiazepines et 6h-pyrrolo[1,2-a][1,4]benzodiazepines antifongiques substituees par des derives bicycliques du benzene

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (fr) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Benzodiazepines 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] substituees en 4, antifongiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107963C2 (en) * 2010-06-07 2015-03-10 Janssen Pharmaceutica Nv Antifungal derivatives of 5,6-dihydro-4 - [(difluoro ethyl) phenyl] -4h-pyrrolo [1,2-a] [1,4] benzodiazepine and 4- (diftoretil) phenyl-6h-pyrolyl [1,2- a] [1,4] benzodiazepine
CA2818623C (fr) * 2010-12-21 2019-03-12 Janssen Pharmaceutica Nv 5,6-dihydro-4h-pyrrolo-[1,2-a][1,4]benzodiazepines et 6h-pyrrolo[1,2-a][1,4]benzodiazepines antifongiques substituees par des derives bicycliques du benzene
UA110640C2 (uk) * 2011-05-05 2016-01-25 Янссен Фармацевтика Нв ПРОТИГРИБКОВІ 5,6-ДИГІДРО-4Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ ТА 6Н-ПІРОЛО[1,2-a][1,4]БЕНЗОДІАЗЕПІНИ, ЯКІ ЗАМІЩЕНІ ГЕТЕРОЦИКЛІЧНИМИ ПОХІДНИМИ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002034752A1 (fr) * 2000-10-23 2002-05-02 Janssen Pharmaceutica N.V. Benzodiazepines 5,6-dihydro-4h-pyrrolo[1,2-a][1,4] substituees en 4, antifongiques

Also Published As

Publication number Publication date
JP5795076B2 (ja) 2015-10-14
IL226442A0 (en) 2013-07-31
JP2013543877A (ja) 2013-12-09
WO2012069380A1 (fr) 2012-05-31
BR112013012547A2 (pt) 2016-08-09
AU2011333918A1 (en) 2013-05-23
US9040523B2 (en) 2015-05-26
EA020837B1 (ru) 2015-02-27
CN103228659A (zh) 2013-07-31
UA109676C2 (xx) 2015-09-25
ES2582313T3 (es) 2016-09-12
ZA201303772B (en) 2017-06-28
HK1254681A1 (zh) 2019-07-26
AP2013006868A0 (en) 2013-05-31
SG190141A1 (en) 2013-06-28
NZ611892A (en) 2014-12-24
MX2013005857A (es) 2013-07-03
MY162808A (en) 2017-07-14
CA2816395A1 (fr) 2012-05-31
CA2816395C (fr) 2019-03-12
CN103228659B (zh) 2017-11-24
US20130274250A1 (en) 2013-10-17
AU2011333918B2 (en) 2016-02-25
CN107964013B (zh) 2020-11-06
IL226442A (en) 2015-10-29
CN107964013A (zh) 2018-04-27
EP2643324B1 (fr) 2016-04-13
EP2643324A1 (fr) 2013-10-02
KR101858630B1 (ko) 2018-05-16
EA201390750A1 (ru) 2013-09-30
KR20130115304A (ko) 2013-10-21

Similar Documents

Publication Publication Date Title
HK1203407A1 (en) Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof [12-b]
HK1185881A1 (zh) 取代的咪唑並 噠嗪
PH12013501402A1 (en) Mesoionic Pyrido [1,2 -A] Pyrimidine Pesticides
ZA201004524B (en) Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
HK1183029A1 (zh) 作為 調節劑的吡唑並 嘧啶和噻吩並 嘧啶衍生物
PL2600719T3 (pl) 2-Podstawione 8-alkilo-7-okso-7,8-dihydropirydo[2,3-d]pirymidyno-6-karbonitryle oraz ich zastosowania
IL221952A (en) Annotations 2, 3-Dihydro-1h - Indene-1-Il-7,2- Diazaspiro [5.3] Noonan and Pharmaceuticals Containing Them
IL219424A0 (en) IMIDAZO [1,2-b] PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
IL229993A (en) 8 - Alkoxy [1,2,4] triazolo [5,1 – c] pyrimidine– 2
ZA201208616B (en) Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
IL221479A0 (en) Triazolo [4,5-b] pyridin derivatives
HK1188792A1 (zh) 二環苯衍生物取代的 -二氫- -吡咯並 苯並二氮雜䓬和 -吡咯並 苯並二氮雜䓬新抗真菌劑
AP3285A (en) Novel antifungal 5,6-dihydro-4-[(difluoroethyl)phenyl]-4H-pyrrolo[1,2-a][1,4]-benzodiazepine and 4-(difluoroethyl)phenyl-6H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives
IL220448A (en) Pyridine [3,2 - d] Pyrimidine - 7 (8h) - Their medical uses and uses
ZA201008178B (en) Imidazo [2,1-b]quinazolin-2-one derivatives and their use as platelet anti-aggregative agents
EP2565194A4 (fr) DÉRIVÉ IMIDAZO[1,2-a]PYRIDINE
EP2578586A4 (fr) Dérivés d'hexahydropyrrolo[3,4-b]pyrrole, leurs procédés de préparation et leurs utilisations pharmaceutiques
HK1206355A1 (en) Piperazino[1,2-a]indol-1-ones and [1,4]diazepino[1,2-a]indol-1-one [12-a]-1-[14][12-a]-1-
IL206666A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
HK1190708A1 (en) Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway [12-b] pi3k/akt
ZA201304074B (en) Pyrazino[2,3-d]isoxazole derivative
AP3518A (en) NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]-BENZODIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH PHENYL DERIVATIVES
IL206668A0 (en) N-PHENYLIMIDAZO[1,2-a]PYRIDINE-2-
AP3511A (en) NOVEL ANTIFUNGAL 5,6-DIHYDRO-4H-PYRROLO[1,2-a][1,4]BENZO-DIAZEPINES AND 6H-PYRROLO[1,2-a][1,4]BENZODIAZEPINES SUBSTITUTED WITH HETEROCYCLIC DERIVATIVES
EP2139329A4 (fr) Hétérocycles à base d'imidazo novateurs