AP3342A - Imidazole derivatives as PDE10A enzyme inhibitors - Google Patents
Imidazole derivatives as PDE10A enzyme inhibitorsInfo
- Publication number
- AP3342A AP3342A AP2013006928A AP2013006928A AP3342A AP 3342 A AP3342 A AP 3342A AP 2013006928 A AP2013006928 A AP 2013006928A AP 2013006928 A AP2013006928 A AP 2013006928A AP 3342 A AP3342 A AP 3342A
- Authority
- AP
- ARIPO
- Prior art keywords
- enzyme inhibitors
- imidazole derivatives
- pde10a enzyme
- pde10a
- imidazole
- Prior art date
Links
- 101001072037 Homo sapiens cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Proteins 0.000 title 1
- 102100036377 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Human genes 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- 150000002460 imidazoles Chemical class 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201001045 | 2010-11-19 | ||
| PCT/DK2011/000136 WO2012065612A1 (fr) | 2010-11-19 | 2011-11-18 | Dérivé d'imidazole en tant qu'inhibiteurs de l'enzyme pde10a |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2013006928A0 AP2013006928A0 (en) | 2013-06-30 |
| AP3342A true AP3342A (en) | 2015-07-31 |
Family
ID=45217102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2013006928A AP3342A (en) | 2010-11-19 | 2011-11-18 | Imidazole derivatives as PDE10A enzyme inhibitors |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP2640731B9 (fr) |
| JP (1) | JP5937608B2 (fr) |
| KR (1) | KR101916487B1 (fr) |
| CN (1) | CN103328487B (fr) |
| AP (1) | AP3342A (fr) |
| AR (1) | AR083926A1 (fr) |
| AU (1) | AU2011331607B2 (fr) |
| BR (1) | BR112013012378A2 (fr) |
| CA (1) | CA2817663C (fr) |
| CR (1) | CR20130226A (fr) |
| DK (1) | DK2640731T3 (fr) |
| EA (1) | EA027082B1 (fr) |
| EC (1) | ECSP13012698A (fr) |
| ES (1) | ES2547090T3 (fr) |
| GE (1) | GEP20156346B (fr) |
| GT (1) | GT201300130A (fr) |
| HU (1) | HUE025596T2 (fr) |
| JO (1) | JO3089B1 (fr) |
| ME (1) | ME02193B (fr) |
| MY (1) | MY163327A (fr) |
| NZ (1) | NZ610353A (fr) |
| PE (1) | PE20141534A1 (fr) |
| PH (1) | PH12013500968A1 (fr) |
| PL (1) | PL2640731T3 (fr) |
| PT (1) | PT2640731E (fr) |
| RS (1) | RS54210B1 (fr) |
| SG (1) | SG190282A1 (fr) |
| SI (1) | SI2640731T1 (fr) |
| TW (1) | TWI541245B (fr) |
| UA (1) | UA112065C2 (fr) |
| WO (1) | WO2012065612A1 (fr) |
| ZA (1) | ZA201303607B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
| WO2012096929A2 (fr) * | 2011-01-11 | 2012-07-19 | Sunovion Pharmaceuticals Inc. | Composés hétéroaryles et leurs procédés d'utilisation |
| WO2013045607A1 (fr) * | 2011-09-30 | 2013-04-04 | H. Lundbeck A/S | Dérivés tricycliques hétéroaromatiques liés à de la quinazoline pouvant être utilisés en tant qu'inhibiteurs de l'enzyme pde10a |
| WO2013107856A1 (fr) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Dérivés d'imidazole utilisés comme inhibiteurs d'enzymes pde10a |
| US9505751B2 (en) | 2012-06-19 | 2016-11-29 | Sunovion Pharmaceuticals Inc. | Substituted [1,2,4]triazolo[1,5-a]pyrazines as phosphodiesterase inhibitors |
| CN103435617B (zh) * | 2013-08-22 | 2016-04-27 | 南京华安药业有限公司 | 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法 |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| ES2967489T3 (es) | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1 |
| MA46621A (fr) | 2016-10-28 | 2021-06-02 | H Lundbeck As | Traitements combinés comprenant l'administration d'imidazopyrazinones |
| EP3532064B1 (fr) | 2016-10-28 | 2020-07-29 | H. Lundbeck A/S | Traitements combinés comprenant des imidazopyrazinones pour le traitement de troubles psychiatriques et/ou cognitifs |
| TW202031250A (zh) | 2018-11-06 | 2020-09-01 | 丹麥商Ｈ 朗德貝克公司 | 用於治療負性症狀和認知損傷之pde10a抑制劑 |
| CN109776527A (zh) * | 2019-02-21 | 2019-05-21 | 药雅科技(上海)有限公司 | 一种5-溴-7-氮杂吲哚的合成方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009152825A1 (fr) * | 2008-06-20 | 2009-12-23 | H. Lundbeck A/S | Nouveau dérivés de phénylimidazole convenant comme inhibiteurs de l'enzyme pde10a |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| WO2005003129A1 (fr) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolodihydroisoquinolines comme inhibiteurs de pde10 |
| WO2005002579A1 (fr) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Derives de pyrrolo-dihydroisoquinoline comme inhibiteurs de pde10 |
| EP1651251A4 (fr) | 2003-07-31 | 2008-06-18 | Bayer Pharmaceuticals Corp | Procedes pour traiter le diabete, et les troubles associes, au moyen d'inhibiteurs des pde10a |
| EP1723134A2 (fr) | 2004-02-18 | 2006-11-22 | Pfizer Products Incorporated | Derives tetrahydroisoquinolinyliques de quinazoline et d'isoquinoline |
| MXPA06014236A (es) | 2004-06-07 | 2007-02-14 | Pfizer Prod Inc | Inhibicion de la fosfodiesterasa 10 como tratamiento para las afecciones relacionadas con el sindrome metabolico y con la obesidad. |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| CA2578996A1 (fr) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | Derives de 4, 6-dialkoxy-cinnoline substitues en position 4 en tant qu'inhibiteurs de phospodiesterase 10 pour le traitement de syndromes psychiatriques ou neurologiques |
| US8133897B2 (en) | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| UA102693C2 (ru) * | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| TW201200516A (en) * | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
| TWI481607B (zh) * | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| TWI485151B (zh) * | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
-
2011
- 2011-11-14 JO JOP/2011/0339A patent/JO3089B1/ar active
- 2011-11-15 TW TW100141570A patent/TWI541245B/zh not_active IP Right Cessation
- 2011-11-18 CN CN201180065325.2A patent/CN103328487B/zh not_active Expired - Fee Related
- 2011-11-18 SI SI201130586T patent/SI2640731T1/sl unknown
- 2011-11-18 HU HUE11793325A patent/HUE025596T2/en unknown
- 2011-11-18 BR BR112013012378A patent/BR112013012378A2/pt not_active Application Discontinuation
- 2011-11-18 DK DK11793325.9T patent/DK2640731T3/en active
- 2011-11-18 KR KR1020137012797A patent/KR101916487B1/ko not_active Expired - Fee Related
- 2011-11-18 GE GEAP201113117A patent/GEP20156346B/en unknown
- 2011-11-18 NZ NZ610353A patent/NZ610353A/en not_active IP Right Cessation
- 2011-11-18 WO PCT/DK2011/000136 patent/WO2012065612A1/fr not_active Ceased
- 2011-11-18 PT PT117933259T patent/PT2640731E/pt unknown
- 2011-11-18 SG SG2013037163A patent/SG190282A1/en unknown
- 2011-11-18 MY MYPI2013001727A patent/MY163327A/en unknown
- 2011-11-18 EA EA201390741A patent/EA027082B1/ru not_active IP Right Cessation
- 2011-11-18 AP AP2013006928A patent/AP3342A/xx active
- 2011-11-18 PL PL11793325T patent/PL2640731T3/pl unknown
- 2011-11-18 PH PH1/2013/500968A patent/PH12013500968A1/en unknown
- 2011-11-18 UA UAA201307630A patent/UA112065C2/uk unknown
- 2011-11-18 PE PE2013001212A patent/PE20141534A1/es active IP Right Grant
- 2011-11-18 CA CA2817663A patent/CA2817663C/fr not_active Expired - Fee Related
- 2011-11-18 EP EP11793325.9A patent/EP2640731B9/fr active Active
- 2011-11-18 RS RS20150574A patent/RS54210B1/sr unknown
- 2011-11-18 AR ARP110104313A patent/AR083926A1/es unknown
- 2011-11-18 AU AU2011331607A patent/AU2011331607B2/en not_active Ceased
- 2011-11-18 JP JP2013539140A patent/JP5937608B2/ja not_active Expired - Fee Related
- 2011-11-18 ME MEP-2015-130A patent/ME02193B/me unknown
- 2011-11-18 ES ES11793325.9T patent/ES2547090T3/es active Active
-
2013
- 2013-05-16 CR CR20130226A patent/CR20130226A/es unknown
- 2013-05-16 GT GT201300130A patent/GT201300130A/es unknown
- 2013-05-17 ZA ZA2013/03607A patent/ZA201303607B/en unknown
- 2013-06-18 EC ECSP13012698 patent/ECSP13012698A/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009152825A1 (fr) * | 2008-06-20 | 2009-12-23 | H. Lundbeck A/S | Nouveau dérivés de phénylimidazole convenant comme inhibiteurs de l'enzyme pde10a |
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