AP233A - Chinese herbal extracts in the treatment of HIV related disease. - Google Patents
Chinese herbal extracts in the treatment of HIV related disease. Download PDFInfo
- Publication number
- AP233A AP233A APAP/P/1991/000304A AP9100304A AP233A AP 233 A AP233 A AP 233A AP 9100304 A AP9100304 A AP 9100304A AP 233 A AP233 A AP 233A
- Authority
- AP
- ARIPO
- Prior art keywords
- extract
- combination
- hiv
- pharmaceutical preparation
- derivative
- Prior art date
Links
- 239000012676 herbal extract Substances 0.000 title claims abstract description 16
- 201000010099 disease Diseases 0.000 title claims abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 8
- 230000000694 effects Effects 0.000 claims abstract description 27
- 230000036436 anti-hiv Effects 0.000 claims abstract description 8
- 241000411851 herbal medicine Species 0.000 claims abstract 4
- 238000000338 in vitro Methods 0.000 claims abstract 4
- 239000000284 extract Substances 0.000 claims description 80
- 239000002207 metabolite Substances 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 16
- 238000003556 assay Methods 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 208000031886 HIV Infections Diseases 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 235000017276 Salvia Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 30
- 230000002401 inhibitory effect Effects 0.000 claims 17
- 108010027044 HIV Core Protein p24 Proteins 0.000 claims 16
- 241000207929 Scutellaria Species 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 241000304195 Salvia miltiorrhiza Species 0.000 claims 4
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 4
- 244000247747 Coptis groenlandica Species 0.000 claims 3
- 235000002991 Coptis groenlandica Nutrition 0.000 claims 3
- 244000116484 Inula helenium Species 0.000 claims 3
- 235000002598 Inula helenium Nutrition 0.000 claims 3
- 241000334154 Isatis tinctoria Species 0.000 claims 3
- 244000167230 Lonicera japonica Species 0.000 claims 3
- 235000017617 Lonicera japonica Nutrition 0.000 claims 3
- 244000233952 Polygonum bistorta Species 0.000 claims 3
- 235000014258 Polygonum bistorta Nutrition 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 2
- 241001438908 Erycibe obtusifolia Species 0.000 claims 2
- 208000037357 HIV infectious disease Diseases 0.000 claims 2
- 102100034343 Integrase Human genes 0.000 claims 2
- 241000112528 Ligusticum striatum Species 0.000 claims 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 241000766026 Coregonus nasus Species 0.000 claims 1
- 241000720991 Illicium Species 0.000 claims 1
- 241000521080 Illicium lanceolatum Species 0.000 claims 1
- 241000244355 Ligusticum Species 0.000 claims 1
- 241000245240 Lonicera Species 0.000 claims 1
- 241001072909 Salvia Species 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000000153 supplemental effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 9
- 241000700605 Viruses Species 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 208000030507 AIDS Diseases 0.000 description 4
- 241000282326 Felis catus Species 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000182988 Assa Species 0.000 description 1
- 241000086212 Colias nina Species 0.000 description 1
- 241000973621 Concinnum ten Species 0.000 description 1
- 235000004237 Crocus Nutrition 0.000 description 1
- 241000596148 Crocus Species 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000666730 Homo sapiens T-complex protein 1 subunit alpha Proteins 0.000 description 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 244000025221 Humulus lupulus Species 0.000 description 1
- 235000008694 Humulus lupulus Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 101100384355 Mus musculus Ctnnbip1 gene Proteins 0.000 description 1
- JOCBASBOOFNAJA-UHFFFAOYSA-N N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid Chemical compound OCC(CO)(CO)NCCS(O)(=O)=O JOCBASBOOFNAJA-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 101100280646 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) fal-1 gene Proteins 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 241001294418 Soloe Species 0.000 description 1
- 206010042135 Stomatitis necrotising Diseases 0.000 description 1
- 102100038410 T-complex protein 1 subunit alpha Human genes 0.000 description 1
- 241000623377 Terminalia elliptica Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 241000625014 Vir Species 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 201000008585 noma Diseases 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002976 reverse transcriptase assay Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54015890A | 1990-06-19 | 1990-06-19 | |
| US07/712,062 US5178865A (en) | 1990-06-19 | 1991-06-07 | Chinese herbal extracts in the treatment of hiv related disease in vitro |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9100304A0 AP9100304A0 (en) | 1991-07-31 |
| AP233A true AP233A (en) | 1993-03-07 |
Family
ID=27066342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1991/000304A AP233A (en) | 1990-06-19 | 1991-06-19 | Chinese herbal extracts in the treatment of HIV related disease. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5178865A (fr) |
| EP (1) | EP0491913A4 (fr) |
| JP (1) | JPH05500824A (fr) |
| AP (1) | AP233A (fr) |
| CA (1) | CA2064743A1 (fr) |
| OA (1) | OA09651A (fr) |
| WO (1) | WO1991019507A1 (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429208B1 (en) * | 1992-03-27 | 2002-08-06 | Regents Of The University Of California | Methods and compositions for restoring impaired cellular immune function |
| US5928645A (en) * | 1992-06-23 | 1999-07-27 | Young Bok Han & Korean Assoc. Of Creation Research | Extracted substance having anti-HIV activity |
| KR950009099B1 (ko) * | 1992-06-23 | 1995-08-14 | 한영복 | 항후천성면역결핍증바이러스효과를갖는생약추출조성물및그추출방법 |
| US5589182A (en) * | 1993-12-06 | 1996-12-31 | Tashiro; Renki | Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression |
| US5531991A (en) * | 1994-05-04 | 1996-07-02 | The Board Of Regents Of Oklahoma State University | Composition and method for treating hyperglycemia utilizing an extract of Polygonum multiflorum |
| KR0145941B1 (ko) * | 1994-06-13 | 1998-08-17 | 김은영 | 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물 |
| KR100346609B1 (ko) * | 1994-12-28 | 2002-11-18 | 주식회사 엘지씨아이 | 금은화로부터세코노가노사이드를추출하는방법 |
| US5837257A (en) * | 1996-07-09 | 1998-11-17 | Sage R&D | Use of plant extracts for treatment of HIV, HCV and HBV infections |
| US5837253A (en) * | 1996-07-26 | 1998-11-17 | Agrogene Ltd. | Preparation and use of Inula extracts as a fungicide for the control of plant diseases |
| WO1998024460A1 (fr) * | 1996-12-05 | 1998-06-11 | Georgetown University | Extraits d'especes de sauge dotees d'une activite antivirale |
| US5770217A (en) * | 1997-07-02 | 1998-06-23 | Atlatl, Inc. | Dietary supplement for hematological, immune and appetite enhancement |
| US6083921A (en) * | 1998-01-12 | 2000-07-04 | Xu; Kai Jian | Pharmaceutical compositions and method of using same |
| US6030622A (en) * | 1998-06-23 | 2000-02-29 | Shehadeh; Ahmad Abdallah | Herbal extract composition and method with immune-boosting capability |
| US6037369A (en) * | 1998-06-25 | 2000-03-14 | Georgetown University School Of Medicine | Compounds obtained from salvia species having antiviral Activity |
| US6043276A (en) * | 1998-06-25 | 2000-03-28 | Georgetown University School Of Medicine | Compounds obtained from salvia species having antiviral activity |
| DE50008328D1 (de) * | 1999-04-14 | 2004-11-25 | Max Zeller & Soehne Ag Romansh | ARZNEIMITTEL ZUR HEMMUNG DES NF-kB TRANSKRIPTIONSFAKTORS |
| US6479466B1 (en) | 1999-08-13 | 2002-11-12 | University Of Maryland | Compositions for treating viral infections, and methods therefor |
| AU2001293048A1 (en) * | 2000-09-26 | 2002-04-08 | The Johns Hopkins University | Antiviral compositions and methods of use |
| US6696094B2 (en) | 2000-10-18 | 2004-02-24 | Tzu-Sheng Wu | Herbal pharmaceutical composition for treatment of HIV/AIDS patients |
| US6455078B1 (en) * | 2000-10-18 | 2002-09-24 | Tzu-Sheng Wu | Medicinal herbal composition for treating liver diseases and HIV |
| KR100413215B1 (ko) * | 2001-02-08 | 2003-12-31 | 주식회사 자광 | 수용성 키토산과 목향추출물로 구성된 천연 셀 전달체 |
| KR20040086246A (ko) * | 2001-12-21 | 2004-10-08 | 이스턴 버지니아 메디컬 스쿨 | 약제의 효과를 분석하는 방법 |
| EP1626729A4 (fr) * | 2003-05-29 | 2006-08-16 | Bio Defense Nutritionals Inc | Compositions et methodes permettant de soulager des symptomes de diverses maladies |
| US7964224B2 (en) * | 2004-03-03 | 2011-06-21 | Beavers Randy L | Process for extraction and standardization of pharmaceutical quality tinctures and extracts from herbal products |
| US8003136B2 (en) * | 2004-03-03 | 2011-08-23 | Randy Beavers | Standardization of botanical products utilizing biological activity as a marker |
| US7556830B2 (en) * | 2005-08-22 | 2009-07-07 | International Patents Holdings, Ltd. | Medicinal herbal composition for treating infection |
| US8067401B2 (en) * | 2007-09-06 | 2011-11-29 | International Patent Holdings Llc | Compounds and compositions for treating infection |
| WO2011077100A1 (fr) | 2009-12-24 | 2011-06-30 | Cipla Limited | Composition antirétrovirale |
| ES2625406T3 (es) | 2010-03-25 | 2017-07-19 | Oregon Health & Science University | Glicoproteínas de CMV y vectores recombinantes |
| SI2691530T1 (en) | 2011-06-10 | 2018-08-31 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
| US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
| EP2679596B1 (fr) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | Variante de la protéine env du VIH-1 |
| EP2848937A1 (fr) | 2013-09-05 | 2015-03-18 | International Aids Vaccine Initiative | Procédés d'identification de nouveaux immunogènes du VIH-1 |
| US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US10682385B2 (en) | 2014-01-10 | 2020-06-16 | Aftab Ahmad | Saffron treatment method for mammalian maladies |
| EP2896396A1 (fr) | 2014-01-20 | 2015-07-22 | Abem Kimya Tibbi Malzemeler Yönetim Danismanligi Temizlik Servis Hizmetleri Sanayi Ve Dis Ticaret Limited Sirketi | Formulation à base de plantes médicinales topiques pour le traitement des plaies topiques |
| FR3021871B1 (fr) * | 2014-06-10 | 2018-07-13 | Aliou Mamadou Balde | Composition a base d'anthostema senegalense utilisee comme medicament contre le sida |
| US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| US9931394B2 (en) | 2015-03-23 | 2018-04-03 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
| CN106198841A (zh) * | 2016-08-31 | 2016-12-07 | 天津中新药业研究中心 | 一种清热解毒凉血通淋药物的质量控制方法 |
| CN108645944B (zh) * | 2018-05-10 | 2020-08-28 | 重庆医药高等专科学校 | 一种金银花总黄酮提取过程中的质量评价方法 |
| CN113082080B (zh) * | 2021-02-23 | 2022-11-15 | 浙江大学 | 八角属植物或其提取物在制备抗动物病毒药物中的用途 |
| JP2024524265A (ja) | 2021-06-24 | 2024-07-05 | リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル | 顔面肩甲上腕筋ジストロフィー（ｆｓｈｄ）の治療方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469685A (en) * | 1979-12-03 | 1984-09-04 | The Kitasato Institute | Process for producing interferon inducers |
| US4906470A (en) * | 1986-09-22 | 1990-03-06 | Yaguang Liu | Pharmaceutical composition for treating and preventing cardiovascular disease |
| AP132A (en) * | 1990-02-01 | 1991-05-19 | Kenya Medical Res Institute | Improved formulation of low-dose interferon alpha. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US308900A (en) * | 1884-12-09 | Bitters | ||
| US98535A (en) * | 1870-01-04 | Improved medical compound | ||
| US241144A (en) * | 1881-05-10 | Medical compound | ||
| US4886665A (en) * | 1987-03-11 | 1989-12-12 | Arcopharma Ltd. | Compositions of oats and nettle extracts to be used as a food additive or pharmaceutical preparation in human health care |
| US4869903A (en) * | 1987-05-29 | 1989-09-26 | Genelabs Incorporated | Method of selectively inhibiting HIV |
| DK362287D0 (da) * | 1987-07-13 | 1987-07-13 | Kurt Baekgaard Osther | Method for rapid and sensitive detection of hiv-1 antibodies |
| US4937074A (en) * | 1988-03-29 | 1990-06-26 | Fox Chase Cancer Center | Method of treating retrovirus infection |
-
1991
- 1991-06-07 US US07/712,062 patent/US5178865A/en not_active Expired - Fee Related
- 1991-06-11 EP EP19910912841 patent/EP0491913A4/en not_active Withdrawn
- 1991-06-11 CA CA002064743A patent/CA2064743A1/fr not_active Abandoned
- 1991-06-11 JP JP3512083A patent/JPH05500824A/ja active Pending
- 1991-06-11 WO PCT/US1991/004126 patent/WO1991019507A1/fr not_active Application Discontinuation
- 1991-06-19 AP APAP/P/1991/000304A patent/AP233A/en active
-
1992
- 1992-02-12 OA OA60148A patent/OA09651A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469685A (en) * | 1979-12-03 | 1984-09-04 | The Kitasato Institute | Process for producing interferon inducers |
| US4906470A (en) * | 1986-09-22 | 1990-03-06 | Yaguang Liu | Pharmaceutical composition for treating and preventing cardiovascular disease |
| AP132A (en) * | 1990-02-01 | 1991-05-19 | Kenya Medical Res Institute | Improved formulation of low-dose interferon alpha. |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2064743A1 (fr) | 1991-12-20 |
| EP0491913A4 (en) | 1993-02-17 |
| JPH05500824A (ja) | 1993-02-18 |
| EP0491913A1 (fr) | 1992-07-01 |
| AP9100304A0 (en) | 1991-07-31 |
| WO1991019507A1 (fr) | 1991-12-26 |
| OA09651A (en) | 1993-05-15 |
| US5178865A (en) | 1993-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP233A (en) | Chinese herbal extracts in the treatment of HIV related disease. | |
| Heiles | 9286 stars: an agglomeration of stellar polarization catalogs | |
| Nordstrom et al. | Plasma prolactin and central D2 receptor occupancy in antipsychotic drug-treated patients | |
| Van Wietmarschen et al. | Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients | |
| Li et al. | Rapid discovery of absorbed constituents and metabolites in rat plasma after the oral administration of Zi Shen Wan using high‐throughput UHPLC–MS with a multivariate analysis approach | |
| CN109085262A (zh) | 血清血浆药物萃取组合物及其用途 | |
| Li et al. | High‐throughput LC–MS method for the rapid characterization of multiple chemical constituents and metabolites of Da‐Bu‐Yin‐Wan | |
| Ruiz et al. | The use of saliva as a biological fluid in relative bioavailability studies: comparison and correlation with plasma results | |
| Tan et al. | Serum metabolomics reveals betaine and phosphatidylcholine as potential biomarkers for the toxic responses of processed Aconitum carmichaelii Debx | |
| Liu et al. | Simultaneous determination of nirmatrelvir and ritonavir in human plasma using LC–MS/MS and its pharmacokinetic application in healthy Chinese volunteers | |
| Cai et al. | Study on chemical fingerprinting of crude and processed Atractylodes macrocephala from different locations in Zhejiang province by reversed-phase high-performance liquid chromatography coupled with hierarchical cluster analysis | |
| Jayasundar et al. | Challenges in integrating component level technology and system level information from Ayurveda: Insights from NMR phytometabolomics and anti-HIV potential of select Ayurvedic medicinal plants | |
| Moss et al. | The comparative disposition and metabolism of dolutegravir, a potent HIV-1 integrase inhibitor, in mice, rats, and monkeys | |
| Cao et al. | Investigation of the chemical changes from crude and processed paeoniae radix alba‐atractylodis macrocephalae rhizoma herbal pair extracts by using Q Exactive high‐performance benchtop quadrupole‐orbitrap LC‐MS/MS | |
| Zhang et al. | Comparative pharmacokinetics of three monoester‐diterpenoid alkaloids after oral administration of Acontium carmichaeli extract and its compatibility with other herbal medicines in Sini Decoction to rats | |
| He et al. | Chemical profile and potential mechanisms of Huo-Tan-Chu-Shi decoction in the treatment of coronary heart disease by UHPLC-Q/TOF-MS in combination with network pharmacology analysis and experimental verification | |
| Bruschettini et al. | DBS–LC–MS/MS assay for caffeine: validation and neonatal application | |
| Calabrese et al. | Molecular networking and collision cross section prediction for structural isomer and unknown compound identification in plant metabolomics: a case study applied to Zhanthoxylum heitzii extracts | |
| Chen et al. | Research on quality markers of Guizhi Fuling prescription for endometriosis treatment based on gray correlation analysis strategy | |
| Lexell et al. | Variability in muscle fibre areas in whole human quadriceps muscle: how to reduce sampling errors in biopsy techniques | |
| Lan et al. | Identifying of anti-thrombin active components from curcumae rhizoma by affinity-ultrafiltration coupled with UPLC-Q-exactive Orbitrap/MS | |
| Sun et al. | Chromatographic fingerprinting analysis of Zhizhu Wan preparation by high-performance liquid chromatography coupled with photodiode array detector | |
| Zaghloul et al. | Clinical efficacy and pharmacokinetics of antimony in cutaneous leishmaniasis patients treated with sodium stibogluconate | |
| Ma et al. | Investigation of the cellular pharmacological mechanism and clinical evidence of the multi-herbal antiarrhythmic Chinese medicine Xin Su Ning | |
| Li et al. | Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography |