AP2015008526A0 - Imidazopyridazine derivatives as gabaa receptor modulators - Google Patents

Imidazopyridazine derivatives as gabaa receptor modulators

Info

Publication number
AP2015008526A0
AP2015008526A0 AP2015008526A AP2015008526A AP2015008526A0 AP 2015008526 A0 AP2015008526 A0 AP 2015008526A0 AP 2015008526 A AP2015008526 A AP 2015008526A AP 2015008526 A AP2015008526 A AP 2015008526A AP 2015008526 A0 AP2015008526 A0 AP 2015008526A0
Authority
AP
ARIPO
Prior art keywords
receptor modulators
gabaa receptor
imidazopyridazine derivatives
imidazopyridazine
derivatives
Prior art date
Application number
AP2015008526A
Other languages
English (en)
Inventor
Christine Anne Louise Watson
Mifune Takeuchi
David Cameron Pyrde
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AP2015008526A0 publication Critical patent/AP2015008526A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
AP2015008526A 2012-12-14 2013-12-04 Imidazopyridazine derivatives as gabaa receptor modulators AP2015008526A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261737157P 2012-12-14 2012-12-14
PCT/IB2013/060631 WO2014091368A1 (en) 2012-12-14 2013-12-04 Imidazopyridazine derivatives as gabaa receptor modulators

Publications (1)

Publication Number Publication Date
AP2015008526A0 true AP2015008526A0 (en) 2015-06-30

Family

ID=49880883

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2015008526A AP2015008526A0 (en) 2012-12-14 2013-12-04 Imidazopyridazine derivatives as gabaa receptor modulators

Country Status (44)

Country Link
US (3) US8952008B2 (zh)
EP (1) EP2938615B1 (zh)
JP (1) JP5869740B2 (zh)
KR (1) KR101746314B1 (zh)
CN (1) CN104837843B (zh)
AP (1) AP2015008526A0 (zh)
AR (1) AR093937A1 (zh)
AU (1) AU2013356894B2 (zh)
BR (1) BR112015014097B1 (zh)
CA (1) CA2892174C (zh)
CL (1) CL2015001652A1 (zh)
CR (1) CR20150254A (zh)
CU (1) CU24338B1 (zh)
CY (1) CY1118568T1 (zh)
DK (1) DK2938615T3 (zh)
DO (1) DOP2015000147A (zh)
EA (1) EA025635B1 (zh)
EC (1) ECSP15029822A (zh)
ES (1) ES2608640T3 (zh)
GE (1) GEP201706710B (zh)
GT (1) GT201500159A (zh)
HK (1) HK1209743A1 (zh)
HR (1) HRP20161559T1 (zh)
HU (1) HUE032400T2 (zh)
IL (1) IL239243A0 (zh)
LT (1) LT2938615T (zh)
MA (1) MA38112B1 (zh)
MD (1) MD4651B1 (zh)
ME (1) ME02566B (zh)
MX (1) MX366023B (zh)
NI (1) NI201500081A (zh)
PE (1) PE20151163A1 (zh)
PH (1) PH12015501293A1 (zh)
PL (1) PL2938615T3 (zh)
PT (1) PT2938615T (zh)
RS (1) RS55307B1 (zh)
SG (1) SG11201503735YA (zh)
SI (1) SI2938615T1 (zh)
TN (1) TN2015000261A1 (zh)
TW (1) TWI478926B (zh)
UA (1) UA112028C2 (zh)
UY (1) UY35185A (zh)
WO (1) WO2014091368A1 (zh)
ZA (1) ZA201504226B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015189744A1 (en) * 2014-06-12 2015-12-17 Pfizer Limited Imidazopyridazine derivatives as modulators of the gabaa receptor activity.
ES2741831T3 (es) 2014-07-31 2020-02-12 Basf Se Proceso para la preparación de pirazoles
KR102585412B1 (ko) 2015-05-11 2023-10-05 바스프 에스이 4-아미노-피리다진의 제조 방법
WO2017098367A1 (en) 2015-12-10 2017-06-15 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
JOP20190053A1 (ar) * 2016-09-23 2019-03-21 Novartis Ag مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط
EA038510B1 (ru) * 2016-09-23 2021-09-08 Новартис Аг Индазольные соединения для применения при повреждениях сухожилий и/или связок
WO2018082964A1 (en) 2016-11-04 2018-05-11 Basf Se Process for the production of pyridazinyl-amides in a one-pot synthesis
JP7119003B2 (ja) 2017-05-02 2022-08-16 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤としての２－（ヘタ）アリール置換縮合二環式ヘテロ環式誘導体
BR112019025636A2 (pt) 2017-06-06 2020-08-25 Urovant Sciences Gmbh método para tratar bexiga hiperativa, método para aumentar relaxamento de músculo liso da bexiga, e composição de dosagem unitária farmacêutica
EP3796907A4 (en) * 2018-05-22 2021-11-03 Neurocycle Therapeutics, Inc. GABAA POSITIVE ALLOSTERIC MODULATING COMPOUNDS FOR THE TREATMENT OF PRURITUS AND / OR DERMATITIS
TWI752400B (zh) * 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
CN116693555A (zh) * 2022-02-25 2023-09-05 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
CN117069725A (zh) * 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6365589B1 (en) * 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
AU1253002A (en) 2000-11-10 2002-05-21 Merck Sharp & Dohme Imidazo-triazine derivatives as ligands for gaba receptors
GB0117277D0 (en) * 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
CA2555263A1 (en) * 2004-02-12 2005-09-01 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
WO2006078891A2 (en) 2005-01-21 2006-07-27 Neurogen Corporation Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives
EP1845098A1 (en) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
JP5361857B2 (ja) 2007-03-23 2013-12-04 ファイザー・リミテッド イオンチャネルの阻害剤
BRPI1006128A2 (pt) 2009-01-12 2016-11-01 Cagen Inc derivados de sulfonamida
CA2778949C (en) * 2009-10-30 2018-02-27 Janssen Pharmaceutica Nv Imidazo[1,2-b]pyridazine derivatives and their use as pde10 inhibitors
WO2012004714A2 (en) * 2010-07-09 2012-01-12 Pfizer Limited Chemical compounds

Also Published As

Publication number Publication date
PH12015501293B1 (en) 2015-08-24
US20150105396A1 (en) 2015-04-16
MA38112B1 (fr) 2018-10-31
SI2938615T1 (sl) 2017-02-28
PL2938615T3 (pl) 2017-04-28
EP2938615A1 (en) 2015-11-04
GT201500159A (es) 2015-09-23
PT2938615T (pt) 2016-12-26
AU2013356894A1 (en) 2015-05-28
PE20151163A1 (es) 2015-08-14
BR112015014097A2 (pt) 2019-12-17
BR112015014097B1 (pt) 2022-11-29
CR20150254A (es) 2015-07-09
DOP2015000147A (es) 2015-09-15
EA201590761A1 (ru) 2015-12-30
RS55307B1 (sr) 2017-03-31
MA38112A1 (fr) 2018-03-30
TWI478926B (zh) 2015-04-01
CU20150058A7 (es) 2015-11-27
UA112028C2 (uk) 2016-07-11
UY35185A (es) 2014-07-31
AU2013356894B2 (en) 2015-11-12
CN104837843B (zh) 2016-08-31
EA025635B1 (ru) 2017-01-30
ES2608640T3 (es) 2017-04-12
DK2938615T3 (da) 2017-01-02
CA2892174C (en) 2018-02-06
MX2015007598A (es) 2015-10-22
WO2014091368A1 (en) 2014-06-19
CU24338B1 (es) 2018-04-03
MD4651B1 (ro) 2019-09-30
AR093937A1 (es) 2015-07-01
IL239243A0 (en) 2015-07-30
MX366023B (es) 2019-06-24
LT2938615T (lt) 2016-12-27
TW201434840A (zh) 2014-09-16
KR101746314B1 (ko) 2017-06-12
CA2892174A1 (en) 2014-06-19
HUE032400T2 (hu) 2017-09-28
ECSP15029822A (es) 2017-08-31
CL2015001652A1 (es) 2015-08-14
US20140171435A1 (en) 2014-06-19
CN104837843A (zh) 2015-08-12
KR20150088877A (ko) 2015-08-03
JP2016503001A (ja) 2016-02-01
GEP201706710B (en) 2017-07-25
ZA201504226B (en) 2016-06-29
EP2938615B1 (en) 2016-10-26
TN2015000261A1 (fr) 2016-10-03
PH12015501293A1 (en) 2015-08-24
US8952008B2 (en) 2015-02-10
MD20150051A2 (ro) 2015-09-30
CY1118568T1 (el) 2017-07-12
HRP20161559T1 (hr) 2016-12-30
HK1209743A1 (zh) 2016-04-08
US20150259352A1 (en) 2015-09-17
ME02566B (me) 2017-02-20
NI201500081A (es) 2015-09-16
SG11201503735YA (en) 2015-07-30
JP5869740B2 (ja) 2016-02-24

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