AP2007004261A0 - Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors - Google Patents

Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors

Info

Publication number
AP2007004261A0
AP2007004261A0 AP2007004261A AP2007004261A AP2007004261A0 AP 2007004261 A0 AP2007004261 A0 AP 2007004261A0 AP 2007004261 A AP2007004261 A AP 2007004261A AP 2007004261 A AP2007004261 A AP 2007004261A AP 2007004261 A0 AP2007004261 A0 AP 2007004261A0
Authority
AP
ARIPO
Prior art keywords
artemisinin
amorpha
diene
conversion
precursors
Prior art date
Application number
AP2007004261A
Other languages
English (en)
Inventor
Neil Stephen Renninger
Derek James Mcphee
Karl Joseph Fisher
Original Assignee
Amyris Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Biotechnologies Inc filed Critical Amyris Biotechnologies Inc
Publication of AP2007004261A0 publication Critical patent/AP2007004261A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D301/00Preparation of oxiranes
    • C07D301/02Synthesis of the oxirane ring
    • C07D301/03Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D321/00Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02Seven-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AP2007004261A 2005-05-27 2006-05-30 Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors AP2007004261A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68571305P 2005-05-27 2005-05-27
US77551706P 2006-02-21 2006-02-21
US11/419,975 US20060270863A1 (en) 2005-05-27 2006-05-23 Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors
PCT/US2006/020806 WO2006128126A1 (en) 2005-05-27 2006-05-30 Conversion of amorpha-4,11- diene to artemisinin and artemisinin precursors

Publications (1)

Publication Number Publication Date
AP2007004261A0 true AP2007004261A0 (en) 2007-12-31

Family

ID=37452381

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2007004261A AP2007004261A0 (en) 2005-05-27 2006-05-30 Conversion of amorpha-4,11-diene to artemisinin and artemisinin precursors

Country Status (10)

Country Link
US (1) US20060270863A1 (es)
EP (1) EP1885728A1 (es)
JP (1) JP2008545716A (es)
KR (1) KR20080041602A (es)
AP (1) AP2007004261A0 (es)
BR (1) BRPI0610056A2 (es)
CA (1) CA2609331A1 (es)
IL (1) IL187590A0 (es)
MX (1) MX2007014896A (es)
WO (1) WO2006128126A1 (es)

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US7838708B2 (en) 2001-06-20 2010-11-23 Grt, Inc. Hydrocarbon conversion process improvements
US20050171393A1 (en) 2003-07-15 2005-08-04 Lorkovic Ivan M. Hydrocarbon synthesis
CA2532367C (en) 2003-07-15 2013-04-23 Grt, Inc. Hydrocarbon synthesis
US7244867B2 (en) 2004-04-16 2007-07-17 Marathon Oil Company Process for converting gaseous alkanes to liquid hydrocarbons
US7674941B2 (en) 2004-04-16 2010-03-09 Marathon Gtf Technology, Ltd. Processes for converting gaseous alkanes to liquid hydrocarbons
US20060100469A1 (en) 2004-04-16 2006-05-11 Waycuilis John J Process for converting gaseous alkanes to olefins and liquid hydrocarbons
US8173851B2 (en) 2004-04-16 2012-05-08 Marathon Gtf Technology, Ltd. Processes for converting gaseous alkanes to liquid hydrocarbons
US8642822B2 (en) 2004-04-16 2014-02-04 Marathon Gtf Technology, Ltd. Processes for converting gaseous alkanes to liquid hydrocarbons using microchannel reactor
US20080275284A1 (en) 2004-04-16 2008-11-06 Marathon Oil Company Process for converting gaseous alkanes to liquid hydrocarbons
NZ588129A (en) 2006-02-03 2012-06-29 Grt Inc Continuous process for converting natural gas to liquid hydrocarbons
EP1993951B1 (en) 2006-02-03 2014-07-30 GRT, Inc. Separation of light gases from bromine
KR100819099B1 (ko) * 2006-10-02 2008-04-03 삼성전자주식회사 가변저항 반도체 메모리 장치
JP2010528054A (ja) 2007-05-24 2010-08-19 ジーアールティー インコーポレイテッド 可逆的なハロゲン化水素の捕捉及び放出を組み込んだ領域反応器
WO2009088404A1 (en) * 2007-12-30 2009-07-16 Amyris Biotechnologies, Inc. Processes for the preparation of artemisinin an its precursors
AU2009243064B2 (en) * 2008-05-02 2013-09-05 Amyris, Inc. Fuel compositions comprising an amorphane or a stereoisomer thereof and methods of making and using same
US8282810B2 (en) 2008-06-13 2012-10-09 Marathon Gtf Technology, Ltd. Bromine-based method and system for converting gaseous alkanes to liquid hydrocarbons using electrolysis for bromine recovery
US8415517B2 (en) 2008-07-18 2013-04-09 Grt, Inc. Continuous process for converting natural gas to liquid hydrocarbons
CN102071246A (zh) * 2009-08-27 2011-05-25 北京科技大学 新型中药制剂的开发与评价
EP2289897A1 (en) * 2009-09-01 2011-03-02 Sanofi-Aventis Photochemical process for producing artemisinin
JP5711745B2 (ja) 2009-09-11 2015-05-07 サノフイ アルテミシニン中間体の製造方法
US8367884B2 (en) 2010-03-02 2013-02-05 Marathon Gtf Technology, Ltd. Processes and systems for the staged synthesis of alkyl bromides
US8198495B2 (en) 2010-03-02 2012-06-12 Marathon Gtf Technology, Ltd. Processes and systems for the staged synthesis of alkyl bromides
US8815050B2 (en) 2011-03-22 2014-08-26 Marathon Gtf Technology, Ltd. Processes and systems for drying liquid bromine
US9035077B2 (en) 2011-05-10 2015-05-19 Indiana University Research & Technology Corporation Total synthesis of artemisinin
US8436220B2 (en) 2011-06-10 2013-05-07 Marathon Gtf Technology, Ltd. Processes and systems for demethanization of brominated hydrocarbons
US8829256B2 (en) 2011-06-30 2014-09-09 Gtc Technology Us, Llc Processes and systems for fractionation of brominated hydrocarbons in the conversion of natural gas to liquid hydrocarbons
US9150535B2 (en) 2011-08-29 2015-10-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for the synthesis of artemisinin
EP2565197A1 (en) 2011-08-29 2013-03-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and device for the synthesis of artemisinin
US8802908B2 (en) 2011-10-21 2014-08-12 Marathon Gtf Technology, Ltd. Processes and systems for separate, parallel methane and higher alkanes' bromination
US9193641B2 (en) 2011-12-16 2015-11-24 Gtc Technology Us, Llc Processes and systems for conversion of alkyl bromides to higher molecular weight hydrocarbons in circulating catalyst reactor-regenerator systems
EP2660234A1 (en) 2012-05-02 2013-11-06 Sanofi Process for the production of artemisinin intermediates
WO2016110874A2 (en) * 2015-01-07 2016-07-14 Ipca Laboratories Limited Process for preparation of artemisinin and its derivatives
DK3294700T3 (da) 2015-05-08 2020-04-14 Basf Agro Bv Fremgangsmåde til fremstilling af limonen-4-ol
EP3294720B1 (en) * 2015-05-08 2020-12-02 BASF Agro B.V. A process for the preparation of terpinolene epoxide
CN105085438B (zh) * 2015-07-31 2018-08-21 中山大学惠州研究院 一种环氧丙烷的制备方法
KR20190017926A (ko) 2016-06-15 2019-02-20 바스프 아그로 비.브이. 사치환된 알켄의 에폭시화 방법
ES2833202T3 (es) 2016-06-15 2021-06-14 Basf Agro Bv Procedimiento para la epoxidación de un alqueno tetrasustituido
CN112538010B (zh) * 2019-09-20 2023-08-11 凯特立斯(深圳)科技有限公司 一种青蒿素类化合物合成关键中间体的制备方法
FR3118964A1 (fr) 2021-01-15 2022-07-22 Demeta Dérivés de valencène et leur utilisation comme agent parfumant ou aromatisant
CN115728408B (zh) * 2022-10-14 2024-05-07 中国中医科学院中药研究所 一种同时测定黄花蒿中七种青蒿素类相关化合物的方法

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US3658925A (en) * 1969-12-29 1972-04-25 Procter & Gamble Metalation of limonene and syntheses of limonene derivatives
US5180840A (en) * 1986-12-18 1993-01-19 Sri International Process for preparing analogs of artemisinin
EP0494209A4 (en) * 1989-09-27 1993-03-10 Rhone-Poulenc Rorer Sa Cyclic peroxyacetal lactone, lactol and ether compounds
US5216175A (en) * 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
US4992561A (en) * 1990-05-11 1991-02-12 The United States Of America As Represented By The Secretary Of The Army Simple conversion of artemisinic acid into artemisinin
BG99545A (en) * 1995-04-03 1998-09-30 Институт по органична химия с център по фитохимия при БАН Method for the preparation of dihydroartemisininsemisuccinate
US5574195A (en) * 1995-06-19 1996-11-12 Doyle E. Chastain Method of preparing selected monocyclic monoterpenes
DE10014669C1 (de) * 2000-03-24 2002-05-23 Council Scient Ind Res Verfahren zur Herstellung von Arteethern aus Dihydroartemisinin
US7230033B2 (en) * 2000-12-08 2007-06-12 United States of America as represented by the Secretary of the Department of Health and Human Services, Center for Disease Control and Prevention Pest control compositions and methods for their use
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US6683193B2 (en) * 2002-03-25 2004-01-27 Council Of Scientific And Industrial Research Single pot conversion of artemisinin into artemether
BR0311627A (pt) * 2002-06-06 2005-08-30 Univ Washington Conjugados covalentes entre endoperóxidos artemisinino-relacionados e proteìnas portadoras de ferro e métodos de utilização
US6750356B1 (en) * 2002-12-02 2004-06-15 Council Of Scientific And Industrial Research Single pot conversion of artemisinin into arteether
US6677463B1 (en) * 2002-12-10 2004-01-13 Council Of Scientific And Industrial Research Single pot conversion of artemisinin to artesunic acid

Also Published As

Publication number Publication date
IL187590A0 (en) 2008-03-20
MX2007014896A (es) 2008-02-14
US20060270863A1 (en) 2006-11-30
BRPI0610056A2 (pt) 2011-10-18
JP2008545716A (ja) 2008-12-18
KR20080041602A (ko) 2008-05-13
EP1885728A1 (en) 2008-02-13
WO2006128126A1 (en) 2006-11-30
CA2609331A1 (en) 2006-11-30

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