AP189A - 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. - Google Patents

5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. Download PDF

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Publication number
AP189A
AP189A APAP/P/1990/000188A AP9000188A AP189A AP 189 A AP189 A AP 189A AP 9000188 A AP9000188 A AP 9000188A AP 189 A AP189 A AP 189A
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AP
ARIPO
Prior art keywords
formula
hydrogen
compound
carbon atoms
carbon
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Application number
APAP/P/1990/000188A
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English (en)
Other versions
AP9000188A0 (en
Inventor
Schmidt Gunther Dr
Engel Wolfhard Dr
Trummlitz Gunter Dr
Eberlein Wolfgang Dr
Hargrave Karl D Dr
Original Assignee
Boehringer Ingelheim Pharmaceuticals Inc
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharmaceuticals Inc, Thomae Gmbh Dr K filed Critical Boehringer Ingelheim Pharmaceuticals Inc
Publication of AP9000188A0 publication Critical patent/AP9000188A0/xx
Application granted granted Critical
Publication of AP189A publication Critical patent/AP189A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1990/000188A 1989-06-28 1990-06-28 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids. AP189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37297489A 1989-06-28 1989-06-28

Publications (2)

Publication Number Publication Date
AP9000188A0 AP9000188A0 (en) 1990-07-31
AP189A true AP189A (en) 1992-05-04

Family

ID=23470402

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000188A AP189A (en) 1989-06-28 1990-06-28 5,11 Dihydro-6H-dipyrido (3,2-b:2, 3 -e)(1,4)-diazepin-6-ones and thions and their use for the treatment of aids.

Country Status (21)

Country Link
EP (1) EP0410148B1 (en:Method)
JP (1) JP2911967B2 (en:Method)
KR (1) KR0160285B1 (en:Method)
AP (1) AP189A (en:Method)
AT (1) ATE103918T1 (en:Method)
AU (1) AU620724B2 (en:Method)
CA (1) CA2019812C (en:Method)
DD (1) DD295849A5 (en:Method)
DE (1) DE69007891T2 (en:Method)
DK (1) DK0410148T3 (en:Method)
ES (1) ES2063202T3 (en:Method)
FI (1) FI92828C (en:Method)
HU (1) HU206504B (en:Method)
IE (1) IE65247B1 (en:Method)
IL (1) IL94883A (en:Method)
NO (1) NO174468B (en:Method)
NZ (1) NZ234261A (en:Method)
OA (1) OA09741A (en:Method)
PT (1) PT94521B (en:Method)
RU (1) RU2024522C1 (en:Method)
ZA (1) ZA904991B (en:Method)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3802334A1 (de) * 1988-01-27 1989-08-10 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2030056C (en) * 1989-11-17 1995-10-17 Karl D. Hargrave 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection
JP2912007B2 (ja) * 1989-11-17 1999-06-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレーテッド ５，１１―ジヒドロ―６Ｈ―ジピリド〔３，２―ｂ：２′，３′―ｅ〕〔１，４〕ジアゼピンおよび該化合物を含有するＨＩＶ感染の予防又は治療用組成物
CA2052946A1 (en) * 1990-10-19 1992-04-20 Karl G. Grozinger Method for the preparation of 5,11-dihydro-6h-dipyrido ¬3,2-b:2', 3'-e| ¬1,4|diazepines
DK0498290T3 (en:Method) * 1991-02-07 1997-02-10 Boehringer Ingelheim Pharma
DE4403311C1 (de) * 1994-02-03 1995-04-20 Boehringer Ingelheim Kg Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on)
PL181323B1 (pl) * 1994-02-18 2001-07-31 Boehringer Ingelheim Pharma 2-heteroarylo-5,11-dihydro-6H-dipirydo[3,2-b:2’,3'-e][1,4] diazepinyi ich zastosowanie w zapobieganiu i leczeniu zakazen HIV PL PL PL
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
RS49808B (sr) * 1997-08-25 2008-08-07 Boehringer Ingelheim Pharmaceuticals Inc., Farmaceutska suspenzija koja sadrži nevirapin hemihidrat
DE10023492A1 (de) * 2000-05-09 2001-11-22 Schering Ag Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
RU2270195C1 (ru) * 2004-06-21 2006-02-20 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ(НПИ) Способ получения 5-амино-3-[n-ацил-n-алкиламино]-1-фенил-1,2,4-триазолов и 5-амино-3-[n-сульфонил-n-алкиламино]-1-фенил-1,2,4-триазолов
RU2277532C1 (ru) * 2005-02-15 2006-06-10 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ (НПИ) Способ получения сульфонилпроизводных 3,5-диамино-1,2,4-триазола
RU2290398C2 (ru) * 2005-02-15 2006-12-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" ГОУ ВПО ЮРГТУ (НПИ) Способ получения 5-амино-3-n-r1-амино-1-r-1,2,4-триазолов
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
KR101194036B1 (ko) 2010-08-18 2012-10-24 한국에너지기술연구원 태양에너지를 활용한 유체가열장치
WO2016083276A1 (de) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Substituierte pyridobenzodiazepinon-derivate und ihre verwendung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131929C (en:Method) * 1966-10-31
GB1262864A (en) * 1968-03-29 1972-02-09 Glaxo Lab Ltd Diazacarbazoles
DE3122670A1 (de) * 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820345A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3820346A1 (de) * 1988-06-15 1989-12-21 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA554134A (en) * 1958-03-11 Hoffmann Karl Thia-aza-cycloheptadiene compounds and process for their manufacture
CA658624A (en) * 1963-02-26 Schmutz Jean Diazepine derivatives
CA783570A (en) * 1968-04-23 Schmidt Gunther 5,6-dihydro-6-oxo-11h-pyrido (2,3-b) (1,4)-benzodiazepines
CA835391A (en) * 1970-02-24 Schmidt Gunther 5,6-dihydro-5-oxo-11h-pyrido (2,3-6) (1,5) benzodiazepine compounds

Also Published As

Publication number Publication date
NO174468C (en:Method) 1994-05-18
ES2063202T3 (es) 1995-01-01
HU206504B (en) 1992-11-30
CA2019812C (en) 2000-11-21
FI92828B (fi) 1994-09-30
HU904021D0 (en) 1990-12-28
IL94883A0 (en) 1991-04-15
NZ234261A (en) 1992-11-25
PT94521A (pt) 1991-02-08
DK0410148T3 (da) 1994-08-08
AU620724B2 (en) 1992-02-20
DD295849A5 (de) 1991-11-14
PT94521B (pt) 1997-02-28
ATE103918T1 (de) 1994-04-15
CA2019812A1 (en) 1990-12-28
FI92828C (fi) 1995-01-10
KR910000727A (ko) 1991-01-30
IE902322A1 (en) 1991-01-16
AP9000188A0 (en) 1990-07-31
IL94883A (en) 1994-10-07
RU2024522C1 (ru) 1994-12-15
KR0160285B1 (ko) 1998-12-01
AU5792190A (en) 1991-01-03
IE902322L (en) 1990-12-28
OA09741A (en) 1993-11-30
EP0410148A1 (en) 1991-01-30
NO902851L (no) 1991-01-02
JPH03115283A (ja) 1991-05-16
DE69007891T2 (de) 1994-08-25
NO174468B (no) 1994-01-31
HUT55017A (en) 1991-04-29
DE69007891D1 (de) 1994-05-11
JP2911967B2 (ja) 1999-06-28
NO902851D0 (no) 1990-06-27
FI903225A0 (fi) 1990-06-27
IE65247B1 (en) 1995-10-18
ZA904991B (en) 1992-03-25
EP0410148B1 (en) 1994-04-06

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