NO20050609L - Krystallinsk fast form av (2S-5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre - Google Patents

Krystallinsk fast form av (2S-5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre

Info

Publication number
NO20050609L
NO20050609L NO20050609A NO20050609A NO20050609L NO 20050609 L NO20050609 L NO 20050609L NO 20050609 A NO20050609 A NO 20050609A NO 20050609 A NO20050609 A NO 20050609A NO 20050609 L NO20050609 L NO 20050609L
Authority
NO
Norway
Prior art keywords
ethanimidoylamino
methylhept
amino
enoic acid
solid form
Prior art date
Application number
NO20050609A
Other languages
English (en)
Inventor
Ann E Hallinan
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of NO20050609L publication Critical patent/NO20050609L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Abstract

(2S,5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre blir krystallisert som et vannfritt, støkiometrisk 1,5 HCl-salt og en skaler krystalliseringsmetode er beskrevet. Saltformen ble karakterisert og den absolutte konfigurasjon av det kirale senter ble bekreftet som "S". (2S,5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre var høytsmeltende og synes akseptabelt ikke-hygroskopisk for anvendelse i et farmasøytisk preparat.
NO20050609A 2002-08-23 2005-02-03 Krystallinsk fast form av (2S-5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre NO20050609L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40552602P 2002-08-23 2002-08-23
PCT/US2003/026347 WO2004018412A1 (en) 2002-08-23 2003-08-22 Crystalline solid form of (2s-5z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid

Publications (1)

Publication Number Publication Date
NO20050609L true NO20050609L (no) 2005-03-21

Family

ID=31946886

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050609A NO20050609L (no) 2002-08-23 2005-02-03 Krystallinsk fast form av (2S-5Z)-2-amino-7-(etanimidoylamino)-2-metylhept-5-enoinsyre

Country Status (21)

Country Link
US (1) US6998503B2 (no)
EP (1) EP1534668B1 (no)
JP (1) JP4708024B2 (no)
KR (1) KR100893647B1 (no)
CN (1) CN100588647C (no)
AR (1) AR041038A1 (no)
AT (1) ATE556047T1 (no)
AU (1) AU2003258327B2 (no)
BR (1) BR0313752A (no)
CA (1) CA2494583C (no)
ES (1) ES2384969T3 (no)
HK (1) HK1078562A1 (no)
IL (2) IL166599A0 (no)
MX (1) MXPA05001708A (no)
NO (1) NO20050609L (no)
NZ (1) NZ538184A (no)
PL (1) PL375557A1 (no)
RU (1) RU2314290C2 (no)
TW (1) TWI340133B (no)
WO (1) WO2004018412A1 (no)
ZA (1) ZA200501134B (no)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
PT751930E (pt) 1994-03-24 2000-04-28 Searle & Co Derivados amidino uteis como inibidores da sintetase de oxido nitrico
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
TWI290130B (en) * 2000-09-15 2007-11-21 Pharmacia Corp 2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
GB0031179D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers

Also Published As

Publication number Publication date
RU2314290C2 (ru) 2008-01-10
AU2003258327A1 (en) 2004-03-11
ES2384969T3 (es) 2012-07-16
KR20050058443A (ko) 2005-06-16
TWI340133B (en) 2011-04-11
CN1678572A (zh) 2005-10-05
WO2004018412A1 (en) 2004-03-04
HK1078562A1 (en) 2006-03-17
KR100893647B1 (ko) 2009-04-17
JP4708024B2 (ja) 2011-06-22
ATE556047T1 (de) 2012-05-15
US6998503B2 (en) 2006-02-14
CN100588647C (zh) 2010-02-10
ZA200501134B (en) 2006-10-25
AR041038A1 (es) 2005-04-27
IL166599A (en) 2010-12-30
AU2003258327B2 (en) 2009-05-21
CA2494583C (en) 2010-02-02
IL166599A0 (en) 2006-01-15
CA2494583A1 (en) 2004-03-04
EP1534668A1 (en) 2005-06-01
JP2005536541A (ja) 2005-12-02
PL375557A1 (en) 2005-11-28
BR0313752A (pt) 2005-06-21
US20040132822A1 (en) 2004-07-08
NZ538184A (en) 2008-02-29
EP1534668B1 (en) 2012-05-02
TW200413291A (en) 2004-08-01
MXPA05001708A (es) 2005-04-19
RU2005104954A (ru) 2005-07-20

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