AR041038A1 - Forma solida cristalina del acido (2s,5z) -2- amino-7-(etanimidoilamino)-2-metilhept-5- enoico - Google Patents

Forma solida cristalina del acido (2s,5z) -2- amino-7-(etanimidoilamino)-2-metilhept-5- enoico

Info

Publication number
AR041038A1
AR041038A1 ARP030103042A ARP030103042A AR041038A1 AR 041038 A1 AR041038 A1 AR 041038A1 AR P030103042 A ARP030103042 A AR P030103042A AR P030103042 A ARP030103042 A AR P030103042A AR 041038 A1 AR041038 A1 AR 041038A1
Authority
AR
Argentina
Prior art keywords
amino
metilhept
etanimidoilamino
enoico
acid form
Prior art date
Application number
ARP030103042A
Other languages
English (en)
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR041038A1 publication Critical patent/AR041038A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
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Abstract

El ácido (2S, 5Z)-2-amino-7-(etanimidoilamino)-2-metilhept-5-enoico se cristaliza como un clorhidrato 1,5 estequiométrico anhidro, y se revela un método de cristalización de etapas. La forma de la sal se caracterizó y la configuración absoluta del centro quiral se confirmó como "S". El ácido (2S,5Z)-2-amino-7-(etanimidoilamino)-2-metilhept-5-enoico tuvo un punto de fusión alto y parece ser aceptablemente no higroscópico para usarse en una composición farmacéutica. Para el tratamiento de una afección clínica para la cual se indica un inhibidor de la sintasa del oxido nítrico.
ARP030103042A 2002-08-23 2003-08-22 Forma solida cristalina del acido (2s,5z) -2- amino-7-(etanimidoilamino)-2-metilhept-5- enoico AR041038A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40552602P 2002-08-23 2002-08-23

Publications (1)

Publication Number Publication Date
AR041038A1 true AR041038A1 (es) 2005-04-27

Family

ID=31946886

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103042A AR041038A1 (es) 2002-08-23 2003-08-22 Forma solida cristalina del acido (2s,5z) -2- amino-7-(etanimidoilamino)-2-metilhept-5- enoico

Country Status (21)

Country Link
US (1) US6998503B2 (es)
EP (1) EP1534668B1 (es)
JP (1) JP4708024B2 (es)
KR (1) KR100893647B1 (es)
CN (1) CN100588647C (es)
AR (1) AR041038A1 (es)
AT (1) ATE556047T1 (es)
AU (1) AU2003258327B2 (es)
BR (1) BR0313752A (es)
CA (1) CA2494583C (es)
ES (1) ES2384969T3 (es)
HK (1) HK1078562A1 (es)
IL (2) IL166599A0 (es)
MX (1) MXPA05001708A (es)
NO (1) NO20050609L (es)
NZ (1) NZ538184A (es)
PL (1) PL375557A1 (es)
RU (1) RU2314290C2 (es)
TW (1) TWI340133B (es)
WO (1) WO2004018412A1 (es)
ZA (1) ZA200501134B (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
PT751930E (pt) 1994-03-24 2000-04-28 Searle & Co Derivados amidino uteis como inibidores da sintetase de oxido nitrico
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
TWI290130B (en) * 2000-09-15 2007-11-21 Pharmacia Corp 2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
GB0031179D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers

Also Published As

Publication number Publication date
RU2314290C2 (ru) 2008-01-10
AU2003258327A1 (en) 2004-03-11
ES2384969T3 (es) 2012-07-16
KR20050058443A (ko) 2005-06-16
TWI340133B (en) 2011-04-11
CN1678572A (zh) 2005-10-05
WO2004018412A1 (en) 2004-03-04
NO20050609L (no) 2005-03-21
HK1078562A1 (en) 2006-03-17
KR100893647B1 (ko) 2009-04-17
JP4708024B2 (ja) 2011-06-22
ATE556047T1 (de) 2012-05-15
US6998503B2 (en) 2006-02-14
CN100588647C (zh) 2010-02-10
ZA200501134B (en) 2006-10-25
IL166599A (en) 2010-12-30
AU2003258327B2 (en) 2009-05-21
CA2494583C (en) 2010-02-02
IL166599A0 (en) 2006-01-15
CA2494583A1 (en) 2004-03-04
EP1534668A1 (en) 2005-06-01
JP2005536541A (ja) 2005-12-02
PL375557A1 (en) 2005-11-28
BR0313752A (pt) 2005-06-21
US20040132822A1 (en) 2004-07-08
NZ538184A (en) 2008-02-29
EP1534668B1 (en) 2012-05-02
TW200413291A (en) 2004-08-01
MXPA05001708A (es) 2005-04-19
RU2005104954A (ru) 2005-07-20

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