BR0313752A - Forma sólida cristalina do ácido (2s,5z)-2-amino-7-(etanimidoilamino)-2-metilept-5-enóic o - Google Patents

Forma sólida cristalina do ácido (2s,5z)-2-amino-7-(etanimidoilamino)-2-metilept-5-enóic o

Info

Publication number
BR0313752A
BR0313752A BR0313752-0A BR0313752A BR0313752A BR 0313752 A BR0313752 A BR 0313752A BR 0313752 A BR0313752 A BR 0313752A BR 0313752 A BR0313752 A BR 0313752A
Authority
BR
Brazil
Prior art keywords
ethanimidoylamino
amino
enoic acid
crystalline solid
solid form
Prior art date
Application number
BR0313752-0A
Other languages
English (en)
Inventor
Ann E Hallinan
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0313752A publication Critical patent/BR0313752A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

"FORMA SóLIDA CRISTALINA DO áCIDO (2S,5Z)-2-AMINO-7-(ETANIMIDOILAMINO)-2-METILEPT-5-ENóIC O". O ácido (2S,5Z)-2-amino-7-(etanimidoilamino)-2metilept-5-enóico é cristalizado como um sal de 1,5 HC1 estequiométrico, anidro, e é revelado um método de cristalização redimensionável. A forma salina foi caracterizada e a configuração absoluta do centro quiral foi confirmada como 'S'. O ácido (2S,5Z)-2-amino-7-(etanimidoilamino)-2metilept-5-enóico é de fusão elevada e parece de forma aceitavelmente não-higroscópico para utilização numa composição farmacêutica.
BR0313752-0A 2002-08-23 2003-08-22 Forma sólida cristalina do ácido (2s,5z)-2-amino-7-(etanimidoilamino)-2-metilept-5-enóic o BR0313752A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40552602P 2002-08-23 2002-08-23
PCT/US2003/026347 WO2004018412A1 (en) 2002-08-23 2003-08-22 Crystalline solid form of (2s-5z)-2-amino-7-(ethanimidoylamino)-2-methylhept-5-enoic acid

Publications (1)

Publication Number Publication Date
BR0313752A true BR0313752A (pt) 2005-06-21

Family

ID=31946886

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313752-0A BR0313752A (pt) 2002-08-23 2003-08-22 Forma sólida cristalina do ácido (2s,5z)-2-amino-7-(etanimidoilamino)-2-metilept-5-enóic o

Country Status (21)

Country Link
US (1) US6998503B2 (pt)
EP (1) EP1534668B1 (pt)
JP (1) JP4708024B2 (pt)
KR (1) KR100893647B1 (pt)
CN (1) CN100588647C (pt)
AR (1) AR041038A1 (pt)
AT (1) ATE556047T1 (pt)
AU (1) AU2003258327B2 (pt)
BR (1) BR0313752A (pt)
CA (1) CA2494583C (pt)
ES (1) ES2384969T3 (pt)
HK (1) HK1078562A1 (pt)
IL (2) IL166599A0 (pt)
MX (1) MXPA05001708A (pt)
NO (1) NO20050609L (pt)
NZ (1) NZ538184A (pt)
PL (1) PL375557A1 (pt)
RU (1) RU2314290C2 (pt)
TW (1) TWI340133B (pt)
WO (1) WO2004018412A1 (pt)
ZA (1) ZA200501134B (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
PT751930E (pt) 1994-03-24 2000-04-28 Searle & Co Derivados amidino uteis como inibidores da sintetase de oxido nitrico
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
TWI290130B (en) * 2000-09-15 2007-11-21 Pharmacia Corp 2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
GB0031179D0 (en) * 2000-12-21 2001-01-31 Glaxo Group Ltd Nitric oxide synthase inhibitors
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers

Also Published As

Publication number Publication date
RU2314290C2 (ru) 2008-01-10
AU2003258327A1 (en) 2004-03-11
ES2384969T3 (es) 2012-07-16
KR20050058443A (ko) 2005-06-16
TWI340133B (en) 2011-04-11
CN1678572A (zh) 2005-10-05
WO2004018412A1 (en) 2004-03-04
NO20050609L (no) 2005-03-21
HK1078562A1 (en) 2006-03-17
KR100893647B1 (ko) 2009-04-17
JP4708024B2 (ja) 2011-06-22
ATE556047T1 (de) 2012-05-15
US6998503B2 (en) 2006-02-14
CN100588647C (zh) 2010-02-10
ZA200501134B (en) 2006-10-25
AR041038A1 (es) 2005-04-27
IL166599A (en) 2010-12-30
AU2003258327B2 (en) 2009-05-21
CA2494583C (en) 2010-02-02
IL166599A0 (en) 2006-01-15
CA2494583A1 (en) 2004-03-04
EP1534668A1 (en) 2005-06-01
JP2005536541A (ja) 2005-12-02
PL375557A1 (en) 2005-11-28
US20040132822A1 (en) 2004-07-08
NZ538184A (en) 2008-02-29
EP1534668B1 (en) 2012-05-02
TW200413291A (en) 2004-08-01
MXPA05001708A (es) 2005-04-19
RU2005104954A (ru) 2005-07-20

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