MX2010012695A - Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico. - Google Patents
Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico.Info
- Publication number
- MX2010012695A MX2010012695A MX2010012695A MX2010012695A MX2010012695A MX 2010012695 A MX2010012695 A MX 2010012695A MX 2010012695 A MX2010012695 A MX 2010012695A MX 2010012695 A MX2010012695 A MX 2010012695A MX 2010012695 A MX2010012695 A MX 2010012695A
- Authority
- MX
- Mexico
- Prior art keywords
- modified
- glucagon
- buffers
- physiological
- stability
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Se divulgan péptidos de glucagón modificados que tienen solubilidad y/o vida media mejoradas mientras que retienen la actividad agonista de glucagon. Los péptidos de glucógeno se han modificado mediante la sustitución de aminoácidos nativos con, y/o además de, aminoácidos cargados al carboxi terminal del péptido. Los agonistas de glucagón modificados se pueden además modificar mediante pegilación, o la adición de un péptido carboxi terminal seleccionado del grupo que consiste de SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23 o ambas para aumentar adicionalmente la solubilidad de los análogos de agonistas de glucagón.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7319308P | 2008-06-17 | 2008-06-17 | |
US7816508P | 2008-07-03 | 2008-07-03 | |
US9041508P | 2008-08-20 | 2008-08-20 | |
PCT/US2009/047437 WO2009155257A1 (en) | 2008-06-17 | 2009-06-16 | Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010012695A true MX2010012695A (es) | 2011-03-15 |
Family
ID=41434405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010012695A MX2010012695A (es) | 2008-06-17 | 2009-06-16 | Analogos de glucagon que exhiben solubilidad y estabilidad aumentadas en soluciones reguladoras de ph fisiologico. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8450270B2 (es) |
EP (1) | EP2307037A4 (es) |
JP (2) | JP5753779B2 (es) |
KR (1) | KR20110039230A (es) |
CN (2) | CN102088989B (es) |
AU (1) | AU2009260301B2 (es) |
CA (1) | CA2727161A1 (es) |
IL (1) | IL209287A (es) |
MX (1) | MX2010012695A (es) |
RU (1) | RU2560254C2 (es) |
TW (1) | TWI541023B (es) |
WO (1) | WO2009155257A1 (es) |
Families Citing this family (107)
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TWI541023B (zh) | 2016-07-11 |
EP2307037A4 (en) | 2011-08-03 |
CA2727161A1 (en) | 2009-12-23 |
JP2015147791A (ja) | 2015-08-20 |
EP2307037A1 (en) | 2011-04-13 |
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US8450270B2 (en) | 2013-05-28 |
WO2009155257A8 (en) | 2010-03-25 |
KR20110039230A (ko) | 2011-04-15 |
TW201010730A (en) | 2010-03-16 |
CN104447980A (zh) | 2015-03-25 |
RU2010151656A (ru) | 2012-07-27 |
AU2009260301B2 (en) | 2015-09-03 |
IL209287A (en) | 2016-09-29 |
JP5753779B2 (ja) | 2015-07-22 |
JP2011524418A (ja) | 2011-09-01 |
RU2560254C2 (ru) | 2015-08-20 |
CN102088989A (zh) | 2011-06-08 |
US20110190200A1 (en) | 2011-08-04 |
AU2009260301A1 (en) | 2009-12-23 |
CN102088989B (zh) | 2014-11-26 |
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