HUP9700885A2 - Eljárás tieno[3,2-c]piridin-származékok előállítására - Google Patents
Eljárás tieno[3,2-c]piridin-származékok előállításáraInfo
- Publication number
- HUP9700885A2 HUP9700885A2 HU9700885A HUP9700885A HUP9700885A2 HU P9700885 A2 HUP9700885 A2 HU P9700885A2 HU 9700885 A HU9700885 A HU 9700885A HU P9700885 A HUP9700885 A HU P9700885A HU P9700885 A2 HUP9700885 A2 HU P9700885A2
- Authority
- HU
- Hungary
- Prior art keywords
- novel process
- pyridine derivatives
- general formula
- thieno
- producing
- Prior art date
Links
- MKYRMMMSZSVIGD-UHFFFAOYSA-N thieno[3,2-c]pyridine Chemical class N1=CC=C2SC=CC2=C1 MKYRMMMSZSVIGD-UHFFFAOYSA-N 0.000 title 1
- 150000003869 acetamides Chemical class 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
A találmány tárgya új eljárás a (VI) általánős képletű metil-[2-(2-tienil)-etilaminő]-2-halőgénfenil)-acetátők előállítására a (VII)általánős képletű acetamid-származékőkból. A (VI) általánős képletűvegyületek között értékes antitrőmbőtikűs hatású gyógyszerhatóanyagőkvannak. ŕ
Priority Applications (39)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700885A HU222283B1 (hu) | 1997-05-13 | 1997-05-13 | Eljárás tieno[3,2-c]piridin-származékok előállítására |
HR980240A HRP980240B1 (en) | 1997-05-13 | 1998-05-06 | A new process for the preparation of a pharmacologically ve substance |
ZA983921A ZA983921B (en) | 1997-05-13 | 1998-05-08 | A new process for the preparation of a pharmacologically active substance |
NZ501577A NZ501577A (en) | 1997-05-13 | 1998-05-11 | Method for making (+)-(S)-(2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester and salts thereof, process characterised by use of methyl hydrogen sulfate |
BRPI9809112-3A BR9809112B1 (pt) | 1997-05-13 | 1998-05-11 | processo para preparação de clopidogrel. |
EP98921670A EP0981529B1 (en) | 1997-05-13 | 1998-05-11 | A new process for the preparation of a pharmacologically active substance |
EEP199900488A EE03925B1 (et) | 1997-05-13 | 1998-05-11 | Farmakoloogiliselt aktiivse aine valmistamise meetod |
AT98921670T ATE212025T1 (de) | 1997-05-13 | 1998-05-11 | Verfahren zur herstellung von einer pharmacologisch aktiven substanz |
AU74448/98A AU735702B2 (en) | 1997-05-13 | 1998-05-11 | A new process for the preparation of a pharmacologically active substance |
DE69803176T DE69803176T2 (de) | 1997-05-13 | 1998-05-11 | Verfahren zur herstellung von einer pharmacologisch aktiven substanz |
IL13277498A IL132774A0 (en) | 1997-05-13 | 1998-05-11 | A new process for preparation of a pharmacologically active substance |
CZ19993939A CZ292820B6 (cs) | 1997-05-13 | 1998-05-11 | Způsob přípravy clopidogrelu a jeho analogů |
US09/423,549 US6180793B1 (en) | 1997-05-13 | 1998-05-11 | Process for the preparation of a pharmacologically active substance |
YUP-587/99A RS49626B (sr) | 1997-05-13 | 1998-05-11 | Novi postupak za dobijanje farmakološki aktivne supstance |
SK1516-99A SK283700B6 (sk) | 1997-05-13 | 1998-05-11 | Spôsob prípravy farmakologicky účinných racemických alebo opticky aktívnych zlúčenín |
RU99126506/04A RU2172315C1 (ru) | 1997-05-13 | 1998-05-11 | Способ получения рацемических или оптически активных метил(2-галогенофенил)(6,7-дигидро-4н-тиено[3,2-с]пиридин-5-ил)ацетатов или их солей |
CN98805036A CN1109036C (zh) | 1997-05-13 | 1998-05-11 | 制备药理活性物质的新方法 |
ES98921670T ES2172141T3 (es) | 1997-05-13 | 1998-05-11 | Nuevo procedimiento para la preparacion de una sustancia farmacologicamente activa. |
PCT/HU1998/000048 WO1998051689A1 (en) | 1997-05-13 | 1998-05-11 | A new process for the preparation of a pharmacologically active substance |
TR1999/02783T TR199902783T2 (xx) | 1997-05-13 | 1998-05-11 | Bir farmakolojik a��dan aktif maddenin haz�rlanmas� i�in yeni bir i�lem. |
DK98921670T DK0981529T3 (da) | 1997-05-13 | 1998-05-11 | Hidtil ukendt fremgangsmåde til fremstilling af farmakologisk aktivt stof |
PT98921670T PT981529E (pt) | 1997-05-13 | 1998-05-11 | Um novo processo para a preparacao de uma substancia farmacologicamente activa |
KR10-1999-7010466A KR100428238B1 (ko) | 1997-05-13 | 1998-05-11 | 약리학적 활성 물질의 제조 방법 |
MEP-1999-587A ME01636B (me) | 1997-05-13 | 1998-05-11 | Novi postupak za dobijanje farmakološki aktivne supstance |
CA002289623A CA2289623C (en) | 1997-05-13 | 1998-05-11 | A new process for the preparation of a pharmacologically active substance |
PL336693A PL194859B1 (pl) | 1997-05-13 | 1998-05-11 | Sposób wytwarzania racemicznych lub optycznie czynnych związków |
JP1998548956A JP4256478B6 (ja) | 1997-05-13 | 1998-05-11 | 薬理学的に活性な物質の新規調製方法 |
DZ980098A DZ2487A1 (fr) | 1997-05-13 | 1998-05-12 | Un nouveau procédé de fabrication d'une substance active sur le plan pharmacologique. |
EG52098A EG21973A (en) | 1997-05-13 | 1998-05-12 | A new process for the preparation of a pharmacolgically active substance |
MYPI98002116A MY121299A (en) | 1997-05-13 | 1998-05-12 | A new process for the preparation of a pharmacologically active substance |
ARP980102220A AR014349A1 (es) | 1997-05-13 | 1998-05-13 | Proceso para la preparacion de [2-(2-tienil)etilamino](2-halogenofenil) acetatos de metilo racemicos u opticamente activos. |
CO98026855A CO4950564A1 (es) | 1997-05-13 | 1998-05-13 | Nuevo proceso para la preparacion de una sustancia farmaco- logimante activa |
TW087109424A TW552263B (en) | 1997-05-13 | 1998-06-12 | A process for the preparation of a racemic or optically active thieno [3,2-c] pyridine derivative or their salts |
SA98190583A SA98190583B1 (ar) | 1997-05-13 | 1998-09-27 | عملية لتحضير مادة فعالة دوائياً |
IDW991592A ID23018A (id) | 1997-05-13 | 1998-11-05 | Proses baru untuk pembuatan zat-zat yang aktif secara farmakologi |
UA99126785A UA66359C2 (uk) | 1997-05-13 | 1998-11-05 | Спосіб одержання рацемічних або оптично активних сполук |
IS5244A IS1883B (is) | 1997-05-13 | 1999-11-11 | Ný aðferð við að framleiða lyfjafræðilega virkar útskiptar-(6,7-díhýdró-4H-þíenó[3,2-C]pýridín-5-ýl)ediksýruafleiður |
NO19995533A NO325419B1 (no) | 1997-05-13 | 1999-11-12 | Ny fremgangsmate for fremstilling av en farmakologisk aktiv substans |
HK00106408A HK1027350A1 (en) | 1997-05-13 | 2000-10-10 | A new process for the preparation of a pharmacologically active substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9700885A HU222283B1 (hu) | 1997-05-13 | 1997-05-13 | Eljárás tieno[3,2-c]piridin-származékok előállítására |
Publications (4)
Publication Number | Publication Date |
---|---|
HUP9700885D0 HUP9700885D0 (en) | 1997-07-28 |
HUP9700885A2 true HUP9700885A2 (hu) | 1999-09-28 |
HUP9700885A3 HUP9700885A3 (en) | 2000-06-28 |
HU222283B1 HU222283B1 (hu) | 2003-05-28 |
Family
ID=90014236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9700885A HU222283B1 (hu) | 1997-05-13 | 1997-05-13 | Eljárás tieno[3,2-c]piridin-származékok előállítására |
Country Status (38)
Country | Link |
---|---|
US (1) | US6180793B1 (hu) |
EP (1) | EP0981529B1 (hu) |
KR (1) | KR100428238B1 (hu) |
CN (1) | CN1109036C (hu) |
AR (1) | AR014349A1 (hu) |
AT (1) | ATE212025T1 (hu) |
AU (1) | AU735702B2 (hu) |
BR (1) | BR9809112B1 (hu) |
CA (1) | CA2289623C (hu) |
CO (1) | CO4950564A1 (hu) |
CZ (1) | CZ292820B6 (hu) |
DE (1) | DE69803176T2 (hu) |
DK (1) | DK0981529T3 (hu) |
DZ (1) | DZ2487A1 (hu) |
EE (1) | EE03925B1 (hu) |
EG (1) | EG21973A (hu) |
ES (1) | ES2172141T3 (hu) |
HK (1) | HK1027350A1 (hu) |
HR (1) | HRP980240B1 (hu) |
HU (1) | HU222283B1 (hu) |
ID (1) | ID23018A (hu) |
IL (1) | IL132774A0 (hu) |
IS (1) | IS1883B (hu) |
ME (1) | ME01636B (hu) |
MY (1) | MY121299A (hu) |
NO (1) | NO325419B1 (hu) |
NZ (1) | NZ501577A (hu) |
PL (1) | PL194859B1 (hu) |
PT (1) | PT981529E (hu) |
RS (1) | RS49626B (hu) |
RU (1) | RU2172315C1 (hu) |
SA (1) | SA98190583B1 (hu) |
SK (1) | SK283700B6 (hu) |
TR (1) | TR199902783T2 (hu) |
TW (1) | TW552263B (hu) |
UA (1) | UA66359C2 (hu) |
WO (1) | WO1998051689A1 (hu) |
ZA (1) | ZA983921B (hu) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2769313B1 (fr) * | 1997-10-06 | 2000-04-21 | Sanofi Sa | Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese |
HU226421B1 (en) * | 1998-11-09 | 2008-12-29 | Sanofi Aventis | Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides |
IN191030B (hu) * | 2001-01-24 | 2003-09-13 | Cadila Healthcare Ltd | |
US6495691B1 (en) | 2001-07-06 | 2002-12-17 | Brantford Chemicals Inc. | Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives |
US6767913B2 (en) | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
ITMI20020933A1 (it) * | 2002-05-03 | 2003-11-03 | Danimite Dipharma S P A | Procedimento per la sintesi di clopidogrel |
IL166593A0 (en) | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US6800759B2 (en) | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
US6812363B2 (en) * | 2002-10-15 | 2004-11-02 | Usv Limited | Racemization of optically active 2-substituted phenyl glycine esters |
US20060100231A1 (en) * | 2003-03-10 | 2006-05-11 | Hetero Drugs Limited | Amorphous clopidogrel hydrogen sulfate |
EP1603920A1 (en) | 2003-03-12 | 2005-12-14 | Cadila Healthcare Ltd. | Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate |
GB0321256D0 (en) * | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
EP1680430B1 (en) | 2003-11-03 | 2010-01-20 | Cadila Healthcare Ltd. | Processes for preparing form i of (s)-(+)- clopidogrel bisulfate |
CA2457459A1 (en) * | 2004-02-11 | 2005-08-11 | Brantford Chemicals Inc. | Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate |
KR100553398B1 (ko) * | 2004-03-12 | 2006-02-16 | 한미약품 주식회사 | 티에노[3,2-c]피리딘 유도체의 제조 방법 및 이에사용되는 중간체 |
US20060154957A1 (en) * | 2004-09-21 | 2006-07-13 | Nina Finkelstein | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
TW200640932A (en) * | 2005-02-24 | 2006-12-01 | Teva Pharma | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
KR100681512B1 (ko) | 2005-03-08 | 2007-02-09 | 주식회사 한서켐 | 클로피도그렐의 신규한 제조 중간체 및 이를 이용한 클로피도그렐의 제조방법 |
KR101235117B1 (ko) | 2005-12-26 | 2013-02-20 | 에스케이케미칼주식회사 | 광학분리에 의한 (s)-(+)-클로피도그렐의 제조방법 |
KR20090013794A (ko) * | 2006-04-27 | 2009-02-05 | 인드-스위프트 래버러토리즈 리미티드 | 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법 |
US20090247569A1 (en) * | 2006-08-03 | 2009-10-01 | Claude Singer | Process for Preparing Clopidogrel Bisulphate |
DK2064217T3 (da) | 2006-09-04 | 2011-05-09 | Ranbaxy Lab Ltd | Forbedret fremgangsmåde til fremstilling af clopidogrel og dets farmaceutisk acceptable salte |
EP1980563A1 (en) | 2007-04-09 | 2008-10-15 | BATTULA, Srinivasa Reddy | Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
US20090264460A1 (en) * | 2008-04-21 | 2009-10-22 | Mamta Mishra | Clopidogrel pharmaceutical formulations |
KR100990949B1 (ko) | 2008-06-09 | 2010-10-29 | 엔자이텍 주식회사 | 클로피도그렐 및 그의 유도체의 제조방법 |
EP2346879A1 (en) * | 2008-10-24 | 2011-07-27 | Sandoz AG | A process for the preparation of s-clopidogrel |
US8563690B2 (en) * | 2008-11-03 | 2013-10-22 | The Board Of Trustees Of The University Of Illinois | Modulation of platelet aggregation |
CN101544655B (zh) * | 2009-05-05 | 2012-07-04 | 上海医药集团股份有限公司 | 噻吩并[3,2-c]吡啶衍生物的制备方法 |
CN101863899B (zh) * | 2010-06-21 | 2013-03-20 | 常州制药厂有限公司 | 一种提高氯吡格雷樟脑磺酸盐拆分收率的方法 |
KR20170004282A (ko) | 2015-07-02 | 2017-01-11 | 류종렬 | 수도 지지부가 구비된 쉐이크 핸드형 탁구 라켓 |
KR20170004283A (ko) | 2015-07-02 | 2017-01-11 | 류종렬 | 그립부가 개선된 쉐이크 핸드형 탁구 라켓 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2530247B1 (fr) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique |
FR2608607B1 (fr) | 1986-12-23 | 1989-04-28 | Sanofi Sa | Procede de preparation de thienylethylamines et dithienylethylamines ainsi obtenues |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
FR2652575B1 (fr) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | Procede de preparation d'acides alpha-bromo phenylacetiques. |
FR2664596B1 (fr) * | 1990-07-10 | 1994-06-10 | Sanofi Sa | Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese. |
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1997
- 1997-05-13 HU HU9700885A patent/HU222283B1/hu active IP Right Grant
-
1998
- 1998-05-06 HR HR980240A patent/HRP980240B1/xx not_active IP Right Cessation
- 1998-05-08 ZA ZA983921A patent/ZA983921B/xx unknown
- 1998-05-11 AT AT98921670T patent/ATE212025T1/de active
- 1998-05-11 WO PCT/HU1998/000048 patent/WO1998051689A1/en active IP Right Grant
- 1998-05-11 DE DE69803176T patent/DE69803176T2/de not_active Expired - Lifetime
- 1998-05-11 SK SK1516-99A patent/SK283700B6/sk not_active IP Right Cessation
- 1998-05-11 ME MEP-1999-587A patent/ME01636B/me unknown
- 1998-05-11 IL IL13277498A patent/IL132774A0/xx not_active IP Right Cessation
- 1998-05-11 RU RU99126506/04A patent/RU2172315C1/ru active
- 1998-05-11 BR BRPI9809112-3A patent/BR9809112B1/pt not_active IP Right Cessation
- 1998-05-11 CN CN98805036A patent/CN1109036C/zh not_active Expired - Lifetime
- 1998-05-11 NZ NZ501577A patent/NZ501577A/en not_active IP Right Cessation
- 1998-05-11 AU AU74448/98A patent/AU735702B2/en not_active Expired
- 1998-05-11 TR TR1999/02783T patent/TR199902783T2/xx unknown
- 1998-05-11 EE EEP199900488A patent/EE03925B1/xx unknown
- 1998-05-11 EP EP98921670A patent/EP0981529B1/en not_active Expired - Lifetime
- 1998-05-11 CA CA002289623A patent/CA2289623C/en not_active Expired - Fee Related
- 1998-05-11 CZ CZ19993939A patent/CZ292820B6/cs not_active IP Right Cessation
- 1998-05-11 KR KR10-1999-7010466A patent/KR100428238B1/ko not_active IP Right Cessation
- 1998-05-11 ES ES98921670T patent/ES2172141T3/es not_active Expired - Lifetime
- 1998-05-11 PT PT98921670T patent/PT981529E/pt unknown
- 1998-05-11 PL PL336693A patent/PL194859B1/pl unknown
- 1998-05-11 DK DK98921670T patent/DK0981529T3/da active
- 1998-05-11 US US09/423,549 patent/US6180793B1/en not_active Expired - Lifetime
- 1998-05-11 RS YUP-587/99A patent/RS49626B/sr unknown
- 1998-05-12 MY MYPI98002116A patent/MY121299A/en unknown
- 1998-05-12 EG EG52098A patent/EG21973A/xx active
- 1998-05-12 DZ DZ980098A patent/DZ2487A1/xx active
- 1998-05-13 AR ARP980102220A patent/AR014349A1/es active IP Right Grant
- 1998-05-13 CO CO98026855A patent/CO4950564A1/es unknown
- 1998-06-12 TW TW087109424A patent/TW552263B/zh not_active IP Right Cessation
- 1998-09-27 SA SA98190583A patent/SA98190583B1/ar unknown
- 1998-11-05 UA UA99126785A patent/UA66359C2/uk unknown
- 1998-11-05 ID IDW991592A patent/ID23018A/id unknown
-
1999
- 1999-11-11 IS IS5244A patent/IS1883B/is unknown
- 1999-11-12 NO NO19995533A patent/NO325419B1/no not_active IP Right Cessation
-
2000
- 2000-10-10 HK HK00106408A patent/HK1027350A1/xx not_active IP Right Cessation
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