EA200601921A1 - Полиморфные формы гидробромида метил-(+)-(s)-альфа-(2-хлорфенил)-6,7-дигидротиено [3,2-c] пиридин-5(4н)-ацетата, гидробромида клопидогреля - Google Patents

Полиморфные формы гидробромида метил-(+)-(s)-альфа-(2-хлорфенил)-6,7-дигидротиено [3,2-c] пиридин-5(4н)-ацетата, гидробромида клопидогреля

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Publication number
EA200601921A1
EA200601921A1 EA200601921A EA200601921A EA200601921A1 EA 200601921 A1 EA200601921 A1 EA 200601921A1 EA 200601921 A EA200601921 A EA 200601921A EA 200601921 A EA200601921 A EA 200601921A EA 200601921 A1 EA200601921 A1 EA 200601921A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrobromide
dihydrothieno
chlorophenyl
clopidogrelium
acetetate
Prior art date
Application number
EA200601921A
Other languages
English (en)
Other versions
EA010831B1 (ru
Inventor
Кейт Ричард Лоример
Алисия Ти Фуай Нг
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200601921A1 publication Critical patent/EA200601921A1/ru
Publication of EA010831B1 publication Critical patent/EA010831B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Изобретение относится к полиморфным формам В, С и D гидробромида метил-(+)-(S)-α-(2-хлорфенил)-6,7-дигидротиено[3,2-С]пиридин-5(4Н)ацетата, к содержащим его фармацевтическим композициям и к способу его применения для ингибирования агрегации тромбоцитов.
EA200601921A 2004-04-20 2005-04-18 ПОЛИМОРФНАЯ ФОРМА D ГИДРОБРОМИДА МЕТИЛ-(+)-(S)-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-C]ПИРИДИН-5(4H)-АЦЕТАТА EA010831B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56379604P 2004-04-20 2004-04-20
PCT/US2005/013146 WO2005103058A1 (en) 2004-04-20 2005-04-18 Polymorphic forms of methyl (+) - (s) -alpha- (2-chlorophenyl) -6, 7-dihydrothieno `3,2-c!pyridine-584h) acetate hydrobromide, clopidrogel hydrobromide

Publications (2)

Publication Number Publication Date
EA200601921A1 true EA200601921A1 (ru) 2007-02-27
EA010831B1 EA010831B1 (ru) 2008-12-30

Family

ID=34966201

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601921A EA010831B1 (ru) 2004-04-20 2005-04-18 ПОЛИМОРФНАЯ ФОРМА D ГИДРОБРОМИДА МЕТИЛ-(+)-(S)-α-(2-ХЛОРФЕНИЛ)-6,7-ДИГИДРОТИЕНО[3,2-C]ПИРИДИН-5(4H)-АЦЕТАТА

Country Status (20)

Country Link
US (1) US20070088049A1 (ru)
EP (1) EP1756116A1 (ru)
JP (1) JP2007533744A (ru)
KR (1) KR20070012675A (ru)
CN (1) CN1997648A (ru)
AU (1) AU2005236034A1 (ru)
BR (1) BRPI0509997A (ru)
CA (1) CA2562507A1 (ru)
CR (1) CR8678A (ru)
EA (1) EA010831B1 (ru)
EC (1) ECSP066932A (ru)
IL (1) IL178680A0 (ru)
MA (1) MA28588B1 (ru)
MX (1) MXPA06012205A (ru)
NO (1) NO20065233L (ru)
NZ (1) NZ551371A (ru)
TN (1) TNSN06331A1 (ru)
UA (1) UA83919C2 (ru)
WO (1) WO2005103058A1 (ru)
ZA (1) ZA200608569B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
WO2006034451A2 (en) * 2004-09-21 2006-03-30 Teva Pharmaceutical Industries Ltd. Crystalline clopidogrel hydrobromide and processes for preparation thereof
SI22492A (sl) * 2007-03-08 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polimorfne oblike klopidogrel hidrobromida
UY31531A1 (es) * 2007-12-17 2009-08-03 Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
ATE530172T1 (de) 2008-02-26 2011-11-15 Lesvi Laboratorios Sl Pharmazeutische formulierungen mit clopidogrel
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
AU1816901A (en) * 1999-12-06 2001-06-12 Euro-Celtique S.A. Benzimidazole compounds having nociceptin receptor affinity
CA2470479A1 (en) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
GB0321256D0 (en) * 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
GB0325603D0 (en) * 2003-11-03 2003-12-10 Sandoz Ag Organic compounds
EA008972B1 (ru) * 2004-01-13 2007-10-26 Зентива А.С. Новые кристаллические формы гидробромида клопидогреля и способы их получения
RU2006133842A (ru) * 2004-02-24 2008-03-27 Зигфрид Дженерикс Интерэшнл Аг (Ch) Фармакологически приемлемые соли клопидогрела

Also Published As

Publication number Publication date
KR20070012675A (ko) 2007-01-26
BRPI0509997A (pt) 2007-10-16
NZ551371A (en) 2010-07-30
EA010831B1 (ru) 2008-12-30
WO2005103058A1 (en) 2005-11-03
ECSP066932A (es) 2006-12-20
CR8678A (es) 2007-08-28
MXPA06012205A (es) 2007-01-31
CA2562507A1 (en) 2005-11-03
NO20065233L (no) 2006-11-14
TNSN06331A1 (en) 2008-02-22
IL178680A0 (en) 2007-02-11
JP2007533744A (ja) 2007-11-22
UA83919C2 (en) 2008-08-26
US20070088049A1 (en) 2007-04-19
ZA200608569B (en) 2007-12-27
MA28588B1 (fr) 2007-05-02
CN1997648A (zh) 2007-07-11
AU2005236034A1 (en) 2005-11-03
EP1756116A1 (en) 2007-02-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU